RECRUITING

Olanzapine Versus Megestrol Acetate for the Treatment of Loss of Appetite Among Advanced Cancer Patients

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Conditions

Advanced Malignant Solid NeoplasmAnorexiaHematopoietic and Lymphoid Cell Neoplasm

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This phase III trial compares the effects of olanzapine versus megestrol acetate in treating loss of appetite in patients with cancer that has spread to other places in the body (advanced). Olanzapine may stimulate and increase appetite. This study aims to find out if olanzapine is better than the usual approach (megestrol acetate) for stimulating appetite and preventing weight loss.

Official Title

A Randomized Phase III Trial of Olanzapine Versus Megestrol Acetate for Cancer-Associated Anorexia

Quick Facts

Study Start:2022-01-03
Study Completion:2026-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04939090

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Women and men of reproductive potential should agree to use an appropriate method of birth control throughout their participation in this study due to the teratogenic potential of the therapy utilized in this trial. Appropriate methods of birth control include abstinence, oral contraceptives, implantable hormonal contraceptives or double barrier method (diaphragm plus condom)
  2. * Diagnosis of advanced cancer
  3. * Patient-reported 2-month weight loss of at least 5 pounds (2.3 kilograms) and/or physician-estimated caloric intake of less than 20 calories/kilogram of body weight per day
  4. * The patient must perceive loss of appetite and/or weight as a problem; and have an appetite score of 4 or worse on the "Please rate your appetite...." question that requires a patient response on a 0-10 numeric rating scale
  5. * Not receiving ongoing tube feedings or parenteral nutrition at the time of registration
  6. * Not currently using systemic adrenal steroids (with the exception of short-term dexamethasone within 3 days of chemotherapy for control of chemotherapy side effects)
  7. * No use of androgens, progesterone analogs, or other appetite stimulants within the past month
  8. * Patient should not have poorly controlled hypertension or congestive heart failure at registration
  9. * Patient should not have an obstruction of the alimentary canal, malabsorption, or intractable vomiting (defined as vomiting more than 3 times per day over the preceding week)
  10. * Not currently using olanzapine for another medical condition or had previously used olanzapine for chronic nausea or for any pre-existing psychotic disorder
  11. * Patient should not have had a previous blood clot at any time in the past
  12. * No history of poorly controlled diabetes
  13. * No symptomatic leptomeningeal disease or known brain metastases as these patients may have difficulty taking oral medications
  14. * No history of hypersensitivity to olanzapine or megestrol acetate
  15. * No COVID-19 infection in the past that, in the opinion of the treating physician, had left patients with compromised taste, which has not resolved at the time of registration
  16. * Not pregnant and not nursing, because this study involves an investigational agent whose genotoxic, mutagenic and teratogenic effects on the developing fetus and newborn are unknown. Therefore, for women of childbearing potential only, a negative urine or serum pregnancy test done =\< 14 days prior to registration is required
  17. * Age \>= 18 years
  18. * Eastern Cooperative Oncology Group (ECOG) performance status 0, 1 or 2
  19. * Estimated life expectancy of 3 months or longer
  20. * Serum creatinine =\< 2.0 mg/dL
  21. * Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) =\< 3 x upper limit of normal (ULN)
  22. * Fasting glucose \< 140 mg/dL
  23. * Granulocytes \> 1000/hpf
  24. * No treatment with another antipsychotic agent, such as risperidone, quetiapine, clozapine, butyrophenone within 30 days of enrollment
  25. * In order to complete the mandatory patient-completed measures, participants must be able to speak and/or read English or Spanish. Sites seeking to enroll Spanish-speaking patients should have access to Spanish speaking staff on site or through the use of a translation service to be able to conduct the informed consent discussion in Spanish, and to conduct the weekly phone calls
  1. * Psychiatric illness which would prevent the patient from giving informed consent
  2. * Medical condition such as uncontrolled infection (including human immunodeficiency virus \[HIV\]), uncontrolled diabetes mellitus or cardiac disease which, in the opinion of the treating physician, would make this protocol unreasonably hazardous for the patient
  3. * Patients who cannot swallow oral formulations of the agents
  4. * Patients with impaired decision-making capacity (such as with a diagnosis of dementia or memory loss) are not eligible for this study
  5. * No presence of a hormone-sensitive tumor, such as breast, endometrial, or prostate cancer (this exclusion criterion is intended to circumvent any confounding antineoplastic effects of megestrol acetate)

Contacts and Locations

Study Contact

Aminah Jatoi, MD
CONTACT
507-266-9160
Jatoi.aminah@mayo.edu

Principal Investigator

Aminah Jatoi, MD
STUDY_CHAIR
Mayo Clinic

Study Locations (Sites)

Arizona Center for Cancer Care - Gilbert
Gilbert, Arizona, 85297
United States
CTCA at Western Regional Medical Center
Goodyear, Arizona, 85338
United States
Arizona Center for Cancer Care-Peoria
Peoria, Arizona, 85381
United States
Arizona Center for Cancer Care - Phoenix
Phoenix, Arizona, 85027
United States
Arizona Center for Cancer Care - Osborn
Scottsdale, Arizona, 85251
United States
Arizona Center for Cancer Care - Scottsdale
Scottsdale, Arizona, 85258
United States
Arizona Center for Cancer Care-Surprise
Surprise, Arizona, 85374
United States
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro, Arkansas, 72401
United States
Epic Care-Dublin
Dublin, California, 94568
United States
Epic Care Partners in Cancer Care
Emeryville, California, 94608
United States
Contra Costa Regional Medical Center
Martinez, California, 94553-3156
United States
Bay Area Tumor Institute
Oakland, California, 94609
United States
Zuckerberg San Francisco General Hospital
San Francisco, California, 94110
United States
Epic Care Cyberknife Center
Walnut Creek, California, 94597
United States
Rocky Mountain Cancer Centers-Aurora
Aurora, Colorado, 80012
United States
Rocky Mountain Cancer Centers-Boulder
Boulder, Colorado, 80304
United States
Rocky Mountain Cancer Centers - Centennial
Centennial, Colorado, 80112
United States
Rocky Mountain Cancer Centers-Midtown
Denver, Colorado, 80218
United States
Rocky Mountain Cancer Centers-Rose
Denver, Colorado, 80220
United States
Mountain Blue Cancer Care Center - Swedish
Englewood, Colorado, 80113
United States
Rocky Mountain Cancer Centers - Swedish
Englewood, Colorado, 80113
United States
Grand Valley Oncology
Grand Junction, Colorado, 81505
United States
Rocky Mountain Cancer Centers-Lakewood
Lakewood, Colorado, 80228
United States
Rocky Mountain Cancer Centers-Sky Ridge
Lone Tree, Colorado, 80124
United States
Rocky Mountain Cancer Centers-Thornton
Thornton, Colorado, 80260
United States
Beebe South Coastal Health Campus
Millville, Delaware, 19967
United States
Delaware Clinical and Laboratory Physicians PA
Newark, Delaware, 19713
United States
Helen F Graham Cancer Center
Newark, Delaware, 19713
United States
Medical Oncology Hematology Consultants PA
Newark, Delaware, 19713
United States
Beebe Health Campus
Rehoboth Beach, Delaware, 19971
United States
Morton Plant Hospital
Clearwater, Florida, 33756
United States
Regional Cancer Center-Lee Memorial Health System
Fort Myers, Florida, 33905
United States
South Florida Baptist Hospital
Plant City, Florida, 33563
United States
Mease Countryside Hospital
Safety Harbor, Florida, 34695
United States
Saint Anthony's Hospital Cancer Care Center
Saint Petersburg, Florida, 33705
United States
Piedmont Hospital
Atlanta, Georgia, 30309
United States
Piedmont Fayette Hospital
Fayetteville, Georgia, 30214
United States
Piedmont Newnan Hospital
Newnan, Georgia, 30265
United States
Piedmont Henry Hospital
Stockbridge, Georgia, 30281
United States
Hawaii Cancer Care - Westridge
'Aiea, Hawaii, 96701
United States
Pali Momi Medical Center
'Aiea, Hawaii, 96701
United States
The Queen's Medical Center - West Oahu
'Ewa Beach, Hawaii, 96706
United States
Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu, Hawaii, 96813
United States
Queen's Cancer Cenrer - POB I
Honolulu, Hawaii, 96813
United States
Queen's Medical Center
Honolulu, Hawaii, 96813
United States
Straub Clinic and Hospital
Honolulu, Hawaii, 96813
United States
Queen's Cancer Center - Kuakini
Honolulu, Hawaii, 96817
United States
Kapiolani Medical Center for Women and Children
Honolulu, Hawaii, 96826
United States
Rush - Copley Medical Center
Aurora, Illinois, 60504
United States
Illinois CancerCare-Bloomington
Bloomington, Illinois, 61704
United States
Illinois CancerCare-Canton
Canton, Illinois, 61520
United States
Illinois CancerCare-Carthage
Carthage, Illinois, 62321
United States
Centralia Oncology Clinic
Centralia, Illinois, 62801
United States
Mount Sinai Hospital Medical Center
Chicago, Illinois, 60608
United States
Northwestern University
Chicago, Illinois, 60611
United States
Carle at The Riverfront
Danville, Illinois, 61832
United States
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois, 62526
United States
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois, 60115
United States
Illinois CancerCare-Dixon
Dixon, Illinois, 61021
United States
Crossroads Cancer Center
Effingham, Illinois, 62401
United States
Illinois CancerCare-Eureka
Eureka, Illinois, 61530
United States
Illinois CancerCare-Galesburg
Galesburg, Illinois, 61401
United States
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois, 60134
United States
Northwestern Medicine Glenview Outpatient Center
Glenview, Illinois, 60026
United States
Northwestern Medicine Grayslake Outpatient Center
Grayslake, Illinois, 60030
United States
Ingalls Memorial Hospital
Harvey, Illinois, 60426
United States
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois, 61443
United States
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois, 60045
United States
Illinois CancerCare-Macomb
Macomb, Illinois, 61455
United States
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois, 61938
United States
Cancer Care Center of O'Fallon
O'Fallon, Illinois, 62269
United States
Northwestern Medicine Orland Park
Orland Park, Illinois, 60462
United States
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois, 61350
United States
Illinois CancerCare-Pekin
Pekin, Illinois, 61554
United States
Illinois CancerCare-Peoria
Peoria, Illinois, 61615
United States
Illinois CancerCare-Peru
Peru, Illinois, 61354
United States
Illinois CancerCare-Princeton
Princeton, Illinois, 61356
United States
West Suburban Medical Center
River Forest, Illinois, 60305
United States
Southern Illinois University School of Medicine
Springfield, Illinois, 62702
United States
Springfield Clinic
Springfield, Illinois, 62702
United States
Memorial Medical Center
Springfield, Illinois, 62781
United States
Carle Cancer Center
Urbana, Illinois, 61801
United States
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois, 60555
United States
Illinois CancerCare - Washington
Washington, Illinois, 61571
United States
Rush-Copley Healthcare Center
Yorkville, Illinois, 60560
United States
Northwest Cancer Center - Main Campus
Crown Point, Indiana, 46307
United States
Northwest Oncology LLC
Dyer, Indiana, 46311
United States
Northwest Cancer Center - Hobart
Hobart, Indiana, 46342
United States
Saint Mary Medical Center
Hobart, Indiana, 46342
United States
Saint Catherine Hospital
Indianapolis, Indiana, 46312
United States
The Community Hospital
Munster, Indiana, 46321
United States
Women's Diagnostic Center - Munster
Munster, Indiana, 46321
United States
Northwest Cancer Center - Valparaiso
Valparaiso, Indiana, 46383
United States
Mary Greeley Medical Center
Ames, Iowa, 50010
United States
McFarland Clinic - Ames
Ames, Iowa, 50010
United States
University of Iowa Healthcare Cancer Services Quad Cities
Bettendorf, Iowa, 52722
United States
McFarland Clinic - Boone
Boone, Iowa, 50036
United States
Oncology Associates at Mercy Medical Center
Cedar Rapids, Iowa, 52403
United States
Iowa Methodist Medical Center
Des Moines, Iowa, 50309
United States
Mission Cancer and Blood - Des Moines
Des Moines, Iowa, 50309
United States
Mercy Medical Center - Des Moines
Des Moines, Iowa, 50314
United States
McFarland Clinic - Trinity Cancer Center
Fort Dodge, Iowa, 50501
United States
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa, 52242
United States
McFarland Clinic - Jefferson
Jefferson, Iowa, 50129
United States
McFarland Clinic - Marshalltown
Marshalltown, Iowa, 50158
United States
Saint Joseph Hospital East
Lexington, Kentucky, 40509
United States
UM Upper Chesapeake Medical Center
Bel Air, Maryland, 21014
United States
UM Saint Joseph Medical Center
Towson, Maryland, 21204
United States
Tufts Medical Center
Boston, Massachusetts, 02111
United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan, 48106
United States
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, Michigan, 48114
United States
Trinity Health Medical Center - Brighton
Brighton, Michigan, 48114
United States
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton, Michigan, 48188
United States
Trinity Health Medical Center - Canton
Canton, Michigan, 48188
United States
Chelsea Hospital
Chelsea, Michigan, 48118
United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, Michigan, 48118
United States
Henry Ford Health Saint John Hospital
Detroit, Michigan, 48236
United States
Great Lakes Cancer Management Specialists-Doctors Park
East China Township, Michigan, 48054
United States
Genesee Cancer and Blood Disease Treatment Center
Flint, Michigan, 48503
United States
Genesee Hematology Oncology PC
Flint, Michigan, 48503
United States
Genesys Hurley Cancer Institute
Flint, Michigan, 48503
United States
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Grosse Pointe Woods, Michigan, 48236
United States
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan, 48154
United States
Great Lakes Cancer Management Specialists-Macomb Medical Campus
Macomb, Michigan, 48044
United States
MyMichigan Medical Center Saginaw
Saginaw, Michigan, 48601
United States
Bhadresh Nayak MD PC-Sterling Heights
Sterling Heights, Michigan, 48312
United States
Great Lakes Cancer Management Specialists-Macomb Professional Building
Warren, Michigan, 48093
United States
Saint John Macomb-Oakland Hospital
Warren, Michigan, 48093
United States
Huron Gastroenterology PC
Ypsilanti, Michigan, 48106
United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan, 48197
United States
Mayo Clinic Health System in Albert Lea
Albert Lea, Minnesota, 56007
United States
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota, 56601
United States
Essentia Health Saint Joseph's Medical Center
Brainerd, Minnesota, 56401
United States
Mercy Hospital
Coon Rapids, Minnesota, 55433
United States
Essentia Health - Deer River Clinic
Deer River, Minnesota, 56636
United States
Essentia Health Saint Mary's - Detroit Lakes Clinic
Detroit Lakes, Minnesota, 56501
United States
Essentia Health Cancer Center
Duluth, Minnesota, 55805
United States
Saint Luke's Hospital of Duluth
Duluth, Minnesota, 55805
United States
Fairview Southdale Hospital
Edina, Minnesota, 55435
United States
Essentia Health - Fosston
Fosston, Minnesota, 56542
United States
Essentia Health Hibbing Clinic
Hibbing, Minnesota, 55746
United States
Abbott-Northwestern Hospital
Minneapolis, Minnesota, 55407
United States
Minneapolis VA Medical Center
Minneapolis, Minnesota, 55417
United States
University of Minnesota/Masonic Cancer Center
Minneapolis, Minnesota, 55455
United States
New Ulm Medical Center
New Ulm, Minnesota, 56073
United States
Essentia Health - Park Rapids
Park Rapids, Minnesota, 56470
United States
Mayo Clinic in Rochester
Rochester, Minnesota, 55905
United States
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, Minnesota, 56303
United States
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota, 55416
United States
Regions Hospital
Saint Paul, Minnesota, 55101
United States
United Hospital
Saint Paul, Minnesota, 55102
United States
Essentia Health Sandstone
Sandstone, Minnesota, 55072
United States
Lakeview Hospital
Stillwater, Minnesota, 55082
United States
Sanford Thief River Falls Medical Center
Thief River Falls, Minnesota, 56701
United States
Essentia Health Virginia Clinic
Virginia, Minnesota, 55792
United States
Rice Memorial Hospital
Willmar, Minnesota, 56201
United States
Sanford Cancer Center Worthington
Worthington, Minnesota, 56187
United States
Baptist Memorial Hospital and Cancer Center-Golden Triangle
Columbus, Mississippi, 39705
United States
Baptist Cancer Center-Grenada
Grenada, Mississippi, 38901
United States
Baptist Memorial Hospital and Cancer Center-Union County
New Albany, Mississippi, 38652
United States
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven, Mississippi, 38671
United States
Saint Francis Medical Center
Cape Girardeau, Missouri, 63703
United States
Saint Luke's Hospital
Chesterfield, Missouri, 63017
United States
Parkland Health Center - Farmington
Farmington, Missouri, 63640
United States
Missouri Baptist Medical Center
Saint Louis, Missouri, 63131
United States
Mercy Hospital Saint Louis
Saint Louis, Missouri, 63141
United States
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri, 63670
United States
Missouri Baptist Sullivan Hospital
Sullivan, Missouri, 63080
United States
BJC Outpatient Center at Sunset Hills
Sunset Hills, Missouri, 63127
United States
Billings Clinic Cancer Center
Billings, Montana, 59101
United States
Benefis Sletten Cancer Institute
Great Falls, Montana, 59405
United States
OptumCare Cancer Care at Seven Hills
Henderson, Nevada, 89052
United States
OptumCare Cancer Care at Charleston
Las Vegas, Nevada, 89102
United States
Comprehensive Cancer Centers of Nevada - Town Center
Las Vegas, Nevada, 89144
United States
OptumCare Cancer Care at Fort Apache
Las Vegas, Nevada, 89148
United States
Comprehensive Cancer Centers of Nevada - Central Valley
Las Vegas, Nevada, 89169
United States
Exeter Hospital
Exeter, New Hampshire, 03833
United States
Lovelace Medical Center-Saint Joseph Square
Albuquerque, New Mexico, 87102
United States
University of New Mexico Cancer Center
Albuquerque, New Mexico, 87106
United States
Memorial Medical Center - Las Cruces
Las Cruces, New Mexico, 88011
United States
James J Peters VA Medical Center
Bronx, New York, 10468
United States
Glens Falls Hospital
Glens Falls, New York, 12801
United States
Queens Hospital Center
Jamaica, New York, 11432
United States
Carolinas Medical Center/Levine Cancer Institute
Charlotte, North Carolina, 28203
United States
Atrium Health Pineville/LCI-Pineville
Charlotte, North Carolina, 28210
United States
Atrium Health University City/LCI-University
Charlotte, North Carolina, 28262
United States
Southeastern Medical Oncology Center-Clinton
Clinton, North Carolina, 28328
United States
Atrium Health Cabarrus/LCI-Concord
Concord, North Carolina, 28025
United States
Levine Cancer Institute - Rutherford
Forest City, North Carolina, 28043
United States
CaroMont Regional Medical Center
Gastonia, North Carolina, 28054
United States
Levine Cancer Institute-Gaston
Gastonia, North Carolina, 28054
United States
Southeastern Medical Oncology Center-Goldsboro
Goldsboro, North Carolina, 27534
United States
Southeastern Medical Oncology Center-Jacksonville
Jacksonville, North Carolina, 28546
United States
Atrium Health Union/LCI-Union
Monroe, North Carolina, 28112
United States
FirstHealth of the Carolinas-Moore Regional Hospital
Pinehurst, North Carolina, 28374
United States
Marion L Shepard Cancer Center - ECU Health Beaufort Hospital
Washington, North Carolina, 27889
United States
Sanford Bismarck Medical Center
Bismarck, North Dakota, 58501
United States
Essentia Health Cancer Center-South University Clinic
Fargo, North Dakota, 58103
United States
Sanford Broadway Medical Center
Fargo, North Dakota, 58122
United States
Sanford Roger Maris Cancer Center
Fargo, North Dakota, 58122
United States
Altru Cancer Center
Grand Forks, North Dakota, 58201
United States
Essentia Health - Jamestown Clinic
Jamestown, North Dakota, 58401
United States
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210
United States
Saint Rita's Medical Center
Lima, Ohio, 45801
United States
Geisinger Medical Center
Danville, Pennsylvania, 17822
United States
Geisinger Medical Center-Cancer Center Hazleton
Hazleton, Pennsylvania, 18201
United States
Geisinger Medical Oncology-Lewisburg
Lewisburg, Pennsylvania, 17837
United States
Geisinger Cancer Services-Pottsville
Pottsville, Pennsylvania, 17901
United States
Guthrie Medical Group PC-Robert Packer Hospital
Sayre, Pennsylvania, 18840
United States
Community Medical Center
Scranton, Pennsylvania, 18510
United States
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania, 18711
United States
Prisma Health Cancer Institute - Spartanburg
Boiling Springs, South Carolina, 29316
United States
Prisma Health Cancer Institute - Easley
Easley, South Carolina, 29640
United States
Tidelands Georgetown Memorial Hospital
Georgetown, South Carolina, 29440
United States
Prisma Health Cancer Institute - Butternut
Greenville, South Carolina, 29605
United States
Prisma Health Cancer Institute - Faris
Greenville, South Carolina, 29605
United States
Prisma Health Greenville Memorial Hospital
Greenville, South Carolina, 29605
United States
Prisma Health Cancer Institute - Eastside
Greenville, South Carolina, 29615
United States
Prisma Health Cancer Institute - Greer
Greer, South Carolina, 29650
United States
Levine Cancer Institute-Rock Hill
Rock Hill, South Carolina, 29732
United States
Prisma Health Cancer Institute - Seneca
Seneca, South Carolina, 29672
United States
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota, 57104
United States
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, 57117-5134
United States
Baptist Memorial Hospital and Cancer Center-Collierville
Collierville, Tennessee, 38017
United States
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, Tennessee, 38120
United States
The Don and Sybil Harrington Cancer Center
Amarillo, Texas, 79106
United States
Baptist Hospitals of Southeast Texas Cancer Center
Beaumont, Texas, 77701
United States
UT Southwestern Simmons Cancer Center - RedBird
Dallas, Texas, 75237
United States
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, 75390
United States
Tarrant County Hospital District/JPS Health Network
Fort Worth, Texas, 76104
United States
UT Southwestern/Simmons Cancer Center-Fort Worth
Fort Worth, Texas, 76104
United States
UT Southwestern Clinical Center at Richardson/Plano
Richardson, Texas, 75080
United States
University of Vermont Medical Center
Burlington, Vermont, 05401
United States
Valley Medical Center
Renton, Washington, 98055
United States
ThedaCare Regional Cancer Center
Appleton, Wisconsin, 54911
United States
Duluth Clinic Ashland
Ashland, Wisconsin, 54806
United States
ThedaCare Cancer Care - Berlin
Berlin, Wisconsin, 54923
United States
Mayo Clinic Health System-Eau Claire Clinic
Eau Claire, Wisconsin, 54701
United States
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin, 54301
United States
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, Wisconsin, 54303
United States
Gundersen Lutheran Medical Center
La Crosse, Wisconsin, 54601
United States
Froedtert Menomonee Falls Hospital
Menomonee Falls, Wisconsin, 53051
United States
Medical College of Wisconsin
Milwaukee, Wisconsin, 53226
United States
ThedaCare Regional Medical Center - Neenah
Neenah, Wisconsin, 54956
United States
ThedaCare Cancer Care - New London
New London, Wisconsin, 54961
United States
Cancer Center of Western Wisconsin
New Richmond, Wisconsin, 54017
United States
Drexel Town Square Health Center
Oak Creek, Wisconsin, 53154
United States
ThedaCare Cancer Care - Oshkosh
Oshkosh, Wisconsin, 54904
United States
ThedaCare Cancer Care - Shawano
Shawano, Wisconsin, 54166
United States
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, Wisconsin, 54235-1495
United States
ThedaCare Cancer Care - Waupaca
Waupaca, Wisconsin, 54981
United States
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend, Wisconsin, 53095
United States

Collaborators and Investigators

Sponsor: Alliance for Clinical Trials in Oncology

  • Aminah Jatoi, MD, STUDY_CHAIR, Mayo Clinic

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-01-03
Study Completion Date2026-12

Study Record Updates

Study Start Date2022-01-03
Study Completion Date2026-12

Terms related to this study

Additional Relevant MeSH Terms

  • Advanced Malignant Solid Neoplasm
  • Anorexia
  • Hematopoietic and Lymphoid Cell Neoplasm