RECRUITING

Using Nicotine to Reverse Age-related Auditory Processing Deficits

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The present study will evaluate the effects of both aging and nicotine on psychophysical tasks and electrophysiological measures. Nicotine will be administered to study participants in the form of gum that is available as an over-the-counter medication. The hypothesis is that nicotine will reverse the detrimental effects of aging on auditory processing. The proposed experiments will characterize the effects of nicotine and may eventually lead to improved treatments of hearing loss in a variety of patient populations and in healthy aging.

Official Title

Using Nicotine to Reverse Age-related Auditory Processing Deficits: Human Psychophysics and Electrophysiology

Quick Facts

Study Start:2022-02-01
Study Completion:2026-06-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04971954

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 85 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * between 18 and 85 years of age
  2. * non-smokers with a score of 0-2 out of 10 maximum on the Fagerström index of smoking dependency
  3. * cognitive performance within two standard deviations of the CERAD mean
  1. * less than 18 or greater than 85 years of age
  2. * deafness or excessive hearing loss
  3. * smokers with a score between 3 and 10 on the Fagerström index of smoking dependency
  4. * history of psychiatric illness, neurological disorders, diabetes mellitus, renal failure, or cardiovascular disease
  5. * regular use of prescription medications (excluding oral contraceptives)
  6. * drug dependency

Contacts and Locations

Study Contact

Mac Morrison
CONTACT
9498249107
mrmorri2@hs.uci.edu

Principal Investigator

Fan-Gang Zeng, PhD
PRINCIPAL_INVESTIGATOR
University of California, Irvine

Study Locations (Sites)

Hearing and Speech Lab
Irvine, California, 92697
United States

Collaborators and Investigators

Sponsor: University of California, Irvine

  • Fan-Gang Zeng, PhD, PRINCIPAL_INVESTIGATOR, University of California, Irvine

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-02-01
Study Completion Date2026-06-30

Study Record Updates

Study Start Date2022-02-01
Study Completion Date2026-06-30

Terms related to this study

Keywords Provided by Researchers

  • nicotine
  • biomarker

Additional Relevant MeSH Terms

  • Auditory Perceptual Impairment
  • Aging