RECRUITING

Brain Mechanisms Supporting Cannabis-induced Pain Relief

Conditions

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The American Academy of Pain Medicine has labeled pain as a "silent epidemic" due to its staggering costs to society (over $500 billion/year) and widespread prevalence (affects over 100 million Americans). Thus, it is imperative to test and validate cost-effective pain therapies. To this extent, cannabis is characterized as one of the most promising therapies to treat a wide spectrum of pain conditions. However, the clinical applicability of cannabis-based pain therapies has been limited due to lacking mechanistic characterization in human-focused studies. Of critical importance, the neural mechanisms supporting cannabis induced pain relief remain unknown. The primary objective of the proposed pilot study is to identify the brain mechanisms supporting the direct alleviation of acutely evoked pain through vaporized cannabis.

Official Title

Brain Mechanisms Supporting Cannabis-induced Pain Relief

Quick Facts

Study Start:2021-05-07
Study Completion:2027-03-15
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04982965

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:21 Years to 65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * are between 21-65 years old
  2. * Volunteers with no previous medical history (e.g., cardiac or pulmonary disease);
  3. * are not currently using any type of cannabis
  4. * have had a previous history with cannabis
  5. * currently 30 days cannabis free
  6. * are not taking opioids
  7. * if female and of a child bearing potential age, are not pregnant or nursing mothers;
  8. * do not lack sensory/motor deficits that preclude participation in pain-inducing procedures
  9. * do not have a lifetime history of dependence on cannabis
  10. * do not have a lifetime history of DSM-IV schizophrenia, bipolar disorder, generalized anxiety or panic disorder, or previous psychosis with or intolerance to cannabinoids
  11. * Prior THC-containing cannabis experience within the past two years
  12. * Agrees not to use cannabis outside of the study during participation in the study
  13. * Agrees not to use opioids or barbiturates during participation in the study
  14. * Agrees not to drive a motor vehicle within 4 hours following last use of inhaled cannabis during participation in the study
  1. * Current or past history of cannabis, alcohol or opioid abuse
  2. * Active pulmonary disease
  3. * Allergy or past adverse effects or negative past experiences from cannabis
  4. * Positive urine drug test for THC, barbiturates, opioids, oxycodone, or methadone prior to study session 1
  5. * Pregnancy
  6. * Breastfeeding
  7. * Prisoner
  8. * Known cognitive impairment
  9. * Institutionalized
  10. * Claustrorphobia
  11. * MRI contraindications

Contacts and Locations

Study Locations (Sites)

Altman Clinical and Translational Research Institute
La Jolla, California, 92093
United States
University of California, San Diego
San Diego, California, 92093
United States

Collaborators and Investigators

Sponsor: University of California, San Diego

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-05-07
Study Completion Date2027-03-15

Study Record Updates

Study Start Date2021-05-07
Study Completion Date2027-03-15

Terms related to this study

Additional Relevant MeSH Terms

  • Pain, Acute