COMPLETED

Diagnostic Potential of UCHL1 in Acute Decompensated Heart Failure

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Autophagy is considered an important component of Heart failure progression. Deubiquitination enzymes play an important role in autophagy. An important regulatory process within the autophagy pathway is ubiquitination. Ubiquitination targets proteins for degradation. On the contrary, de-ubiquitinating proteins (such as UCHL1) reverses this process. Studies have demonstrated deubiquitination to be linked to certain pathological processes, such as heart failure. UCHL1 will be examined as a potential marker of disease progression in acute decompensated heart failure.

Official Title

To Explore the Potential of UCH-L1 as a Novel Therapeutic and Diagnostic Target in Heart Failure

Quick Facts

Study Start:2021-06-01
Study Completion:2025-03-17
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT04999995

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Admission for decompensated HF (traditional diagnostic criteria will be utilized for diagnosing ADHF - presence of dyspnea as presenting complaint; evidence of volume overload - peripheral or pulmonary edema, elevated jugular venous pressure \> 10 cmH2O, presence of hepatojugular reflux, or ascites; elevated B-type Natriuretic Peptide (\>100ng/ml); evidence of pulmonary vascular congestion on chest x-ray1, or Admission for dyspnea that is NOT related to ADHF (absence of all HF symptoms and signs mentioned in ADHF inclusion criteria- except for dyspnea as presenting complaint)
  2. * Able to give informed consent
  3. * Age \>= 18 years
  1. * Mortality during inpatient observation
  2. * Presence of acute stroke (ischemic or hemorrhagic)
  3. * Presence of intracranial hemorrhage
  4. * History of acute stroke (ischemic or hemorrhagic) or intracranial hemorrhage within the preceding 6 months
  5. * Presence of decompensated liver disease (elevated ALT/AST; ascites; Acute variceal bleeding; or hepatic encephalopathy)
  6. * Presence of sepsis
  7. * Presence of severe hyponatremia (Serum sodium \< 130 meq/L)
  8. * Active malignancy (undergoing chemotherapy, radiation therapy, or planned surgical intervention)
  9. * SARS-CoV-2 positive during the current admission

Contacts and Locations

Principal Investigator

Taixing Cui, PhD MB
PRINCIPAL_INVESTIGATOR
Wm. Jennings Bryan Dorn VA Medical Center, Columbia, SC

Study Locations (Sites)

Wm. Jennings Bryan Dorn VA Medical Center, Columbia, SC
Columbia, South Carolina, 29209-1638
United States

Collaborators and Investigators

Sponsor: VA Office of Research and Development

  • Taixing Cui, PhD MB, PRINCIPAL_INVESTIGATOR, Wm. Jennings Bryan Dorn VA Medical Center, Columbia, SC

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-06-01
Study Completion Date2025-03-17

Study Record Updates

Study Start Date2021-06-01
Study Completion Date2025-03-17

Terms related to this study

Additional Relevant MeSH Terms

  • Heart Failure
  • Dyspnea; Cardiac