RECRUITING

Restricted or Liberal Antibiotics After Appendectomy - Denver Health

Description

The purpose of this study is to see if decreasing the amount of antibiotics after appendicitis surgery can decrease the risk of adverse effects associated with antibiotics while at the same time ensuring participant safety.

Conditions

Appendicitis
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Related Conditions:

Appendicitis

Study Overview

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Study Details

Study overview

The purpose of this study is to see if decreasing the amount of antibiotics after appendicitis surgery can decrease the risk of adverse effects associated with antibiotics while at the same time ensuring participant safety.

Complex And Simple Appendicitis: REstrictive or Liberal Post-operative Antibiotic eXposure (CASA RELAX) Using Desirability of Outcome Ranking (DOOR) and Response Adjusted for Duration of Antibiotic Risk (RADAR): A Randomized Controlled Trial at Denver Health

Restricted or Liberal Antibiotics After Appendectomy - Denver Health

Condition
Appendicitis
Intervention / Treatment

-

Contacts and Locations

Denver

Denver Health and Hospital Authority, Denver, Colorado, United States, 80204-4507

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age ≥ 18 years
  • * Planned appendectomy (laparoscopic or open) for simple or complicated (perforated or gangrenous) appendicitis
  • * Working telephone number or reliable method to contact patient after hospital discharge
  • * Unable to consent
  • * Pregnant Women
  • * Prisoners
  • * Immunocompromised as determined by clinical team, or patients actively receiving steroids, chemotherapy, or immunosuppressing medications (for example tacrolimus), or patients with active hematologic malignancy affecting the immune system, leukopenia, or end-stage AIDS
  • * Heart failure
  • * Allergy to bupivacaine
  • * Unlikely to comply with treatment or follow-up
  • * Inpatient consultation for appendicitis
  • * Clinically suspected of sepsis based on Sepsis-3 definition
  • * Current use of antibiotics for other indications
  • * Uncontrolled hyperglycemia or Type 1 Diabetes
  • * Surgeon preference
  • * Patient preference
  • * Research team unavailable

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Denver Health and Hospital Authority,

Daniel D Yeh, MD, MHPE, PRINCIPAL_INVESTIGATOR, Denver Health and Hospital Authority

Study Record Dates

2026-07-31