RECRUITING

Late Onset Alzheimer's Disease

Description

The goal of this study is to is to focus on the genetic influences on Alzheimer's Disease (AD) risk. The investigators are looking for families and/or individuals (affected or unaffected) of any ethic background (African American, Caucasian, and Hispanics) with a family history of AD and willing to participate.

Conditions

Alzheimer Disease
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Related Conditions:

Alzheimer Disease

Study Overview

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Study Details

Study overview

The goal of this study is to is to focus on the genetic influences on Alzheimer's Disease (AD) risk. The investigators are looking for families and/or individuals (affected or unaffected) of any ethic background (African American, Caucasian, and Hispanics) with a family history of AD and willing to participate.

Late Onset Alzheimer's Disease

Late Onset Alzheimer's Disease

Condition
Alzheimer Disease
Intervention / Treatment

-

Contacts and Locations

Washington

University of Washington, Washington, District of Columbia, United States, 98105

Miami

University of Miami, Miami, Florida, United States, 33124

Aurora

Rush University, Aurora, Illinois, United States, 60612

Bloomington

Indiana University, Bloomington, Indiana, United States, 47405

Indianapolis

NCRAD at Indiana University, Indianapolis, Indiana, United States, 46202

Rochester

Mayo Clinic, Rochester, Minnesota, United States, 55901

Saint Louis

Joanne Norton, Saint Louis, Missouri, United States, 63130

New York

Columbia University Irving Medical Center, New York, New York, United States, 10032

Raleigh

North Carolina State University, Raleigh, North Carolina, United States, 27695

Pittsburgh

University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 15213

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Established diagnosis of definite or probable AD or have a diagnosis of a related neurodegenerative disorder such as Frontotemporal Dementia (FTD) or Lewy Body Dementia (LBD) (will also recruit sporadic FTD and LBD) cases.
  • * a living sibling with probable or possible AD;
  • * a third living relative affected with AD (onset age 50 or older) or unaffected (60 or older);
  • * participants in the proband's generation with an identified companion serving as an informant;
  • * participants who have capacity to consent or participants lacking capacity to consent with a surrogate/proxy in place to provide consent.
  • * failure to identify an appropriate informant;
  • * uncertainty of the clinical diagnosis of Alzheimer's disease or other related disorder;
  • * discovery of additional diagnosis that could account for the clinical manifestations;
  • * unwillingness to participate;
  • * failure to identify a living sibling with AD or other related disorder (except in the cases of sporadic FTD and sporadic LBD);
  • * participants lacking the capacity to consent who do not have a surrogate or proxy or next of kin to provide consent.

Ages Eligible for Study

55 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Columbia University,

Richard P. Mayeux, MD, MSc, PRINCIPAL_INVESTIGATOR, Columbia University

Study Record Dates

2026-09