RECRUITING

Microbiome and Association With Implant Infections

Description

The most common tissue expander-related infections are from Staphylococcus and Pseudomonas species. In addition, from breast tissue microbiome studies, Staphylococcus and Pseudomonas show variable abundance across samples. The investigator hypothesizes that participants undergoing mastectomy with high initial abundance of Staphylococcus and/or Pseudomonas are more likely to develop subsequent tissue expander-related infections from these respective organisms.

Conditions

Breast CancerBreast Cancer FemaleGenetic Predisposition to Disease
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Related Conditions:

Breast CancerBreast Cancer FemaleGenetic Predisposition to Disease

Study Overview

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Study Details

Study overview

The most common tissue expander-related infections are from Staphylococcus and Pseudomonas species. In addition, from breast tissue microbiome studies, Staphylococcus and Pseudomonas show variable abundance across samples. The investigator hypothesizes that participants undergoing mastectomy with high initial abundance of Staphylococcus and/or Pseudomonas are more likely to develop subsequent tissue expander-related infections from these respective organisms.

Microbiome and Association With Implant Infections: Investigating the Impact of Antibiotics on the Gut and Breast Microbiomes Post-mastectomy With Implant-based Breast Reconstruction

Microbiome and Association With Implant Infections

Condition
Breast Cancer
Intervention / Treatment

-

Contacts and Locations

San Francisco

University of California, San Francisco, San Francisco, California, United States, 94143

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Patients must have histologically confirmed breast malignancy OR genetic predisposition to breast cancer.
  • 2. Age \>= 18 years
  • 3. Scheduled to undergo mastectomy with the immediate placement of tissue expanders or implant placement
  • 4. Ability to understand a written informed consent document, and the willingness to sign it
  • 5. At least 4 weeks post-completion of chemotherapy or radiation therapy.
  • 1. Any significant medical condition or laboratory abnormalities, which places the subject at unacceptable risk if he/she were to participate in the study
  • 2. Pregnant or breastfeeding
  • 3. Patients who have taken antibiotics within 90 days of the consent date
  • 4. Patients who have taken probiotics within 90 days of the consent date
  • 5. Patients who have a documented or reported allergic reaction to the outlined antibiotics to be used in this study
  • 6. Male patients

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, San Francisco,

Merisa Piper, MD, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

2025-12-31