RECRUITING

Two Studies for Patients With Unfavorable Intermediate Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a Higher Gene Risk Score, The Guidance Trial

Conditions

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This phase III trial uses the Decipher risk score to guide therapy selection. Decipher score is based on the activity of 22 genes in prostate tumor and may predict how likely it is for recurrent prostate cancer to spread (metastasize) to other parts of the body. Decipher score in this study is used for patient selection and the two variations of treatment to be studied: intensification for higher Decipher score or de-intensification for low Decipher score. Patients with higher Decipher risk score will be assigned to the part of the study that compares the use of 6 months of the usual treatment (hormone therapy and radiation treatment) to the use of darolutamide plus the usual treatment (intensification). The purpose of this section of the study is to determine whether the additional drug can reduce the chance of cancer coming back and spreading in patients with higher Decipher score. The addition of darolutamide to the usual treatment may better control the cancer and prevent it from spreading. Alternatively, patients with low Decipher risk score will be assigned to the part of the study that compares the use of radiation treatment alone (de-intensification) to the usual approach (6 months of hormone therapy plus radiation). The purpose of this part of the study is to determine if radiation treatment alone is as effective compared to the usual treatment without affecting the chance of tumor coming back in patients with low Decipher score prostate cancer. Radiation therapy uses high energy to kill tumor cells and reduce the tumor size. Hormone therapy drugs such as darolutamide suppress or block the production or action of male hormones that play role in prostate cancer development. Effect of radiation treatment alone in patients with low Decipher score prostate cancer could be the same as the usual approach in stabilizing prostate cancer and preventing it from spreading, while avoiding the side effects associated with hormonal therapy.

Official Title

Parallel Phase III Randomized Trials of Genomic-Risk Stratified Unfavorable Intermediate Risk Prostate Cancer: De-Intensification and Intensification Clinical Trial Evaluation (GUIDANCE)

Quick Facts

Study Start:2021-12-06

Study Completion:2026-11-11

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT05050084

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years

Sexes Eligible for Study:MALE

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Pathologically (histologically or cytologically) proven diagnosis of adenocarcinoma of the prostate within 270 days prior to registration * Unfavorable intermediate risk prostate cancer, defined as having ALL the following bulleted criteria: * Has at least one intermediate risk factor (IRF): * PSA 10-20 ng/mL * Clinical stage T2b-c (digital rectal examination \[DRE\] and/or imaging) by American Joint Committee on Cancer (AJCC) 8th edition * Gleason score 7 (Gleason 3+4 or 4+3 \[ International Society of Urological Pathology (ISUP) Grade Group 2-3\]) * Has ONE or more of the following 'unfavorable' intermediate-risk designators: * \> 1 immature reticulocyte fraction (IRF) * Gleason 4+3=7 (ISUP Grade Group 3) * \>= 50% of biopsy cores positive * Biopsies may include 'sextant' sampling of right/left regions of the prostate, often labeled base, mid-gland and apex. All such 'sextant' biopsy cores should be counted. Men may also undergo 'targeted' sampling of prostate lesions (guided by MRI, ultrasound or other approaches). A targeted lesion that is biopsied more than once and demonstrates cancer (regardless of number of targeted cores involved) should count as a single additional positive core sampled and positive. In cases of uncertainty, count the biopsy sampling as sextant core(s) * Absence of high-risk features * Appropriate stage for study entry based on the following diagnostic workup: * History/physical examination within 120 days prior to registration; * Negative bone imaging (M0) within 120 days prior to registration; Note: Tc-99m bone scan or sodium fluoride (NaF) positron emission tomography (PET) are allowed. Equivocal bone scan findings are allowed if plain films X-ray, computed tomography (CT) or magnetic resonance imaging (MRI) are negative for metastasis at the concerned site(s). While a negative fluciclovine, choline, or prostate specific membrane antigen (PSMA) PET may be counted as acceptable substitute for bone imaging, any suspicious findings must be confirmed and correlated with conventional imaging (Tc-99m bone scan, NaF PET, CT, X-ray, or MRI) to determine eligibility based on the latter modalities (e.g. M0 based on conventional imaging modalities) * Clinically negative lymph nodes (N0) as established by conventional imaging (pelvic +/- abdominal CT or MR), within 120 days prior to registration. Patients with lymph nodes equivocal or questionable by imaging are eligible if the nodes are =\< 1.0 cm in short axis and/or if biopsy is negative. * Age \>= 18 * Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 within 120 days prior to registration * Non-castrate testosterone level (\> 50 ng/dL) within 120 days prior to registration * Absolute neutrophil \>= 1,000 cells/mm\^3 (within 120 days prior to registration) * Hemoglobin \>= 8.0 g/dL, independent of transfusion and/or growth factors (within 120 days prior to registration) * Platelet count \>= 100,000 cells/mm\^3 independent of transfusion and/or growth factors (within 120 days prior to registration) * Creatinine clearance (CrCl) \>= 30 mL/min estimated by Cockcroft-Gault equation (within 120 days prior to registration) * For African American patients specifically whose renal function is not considered adequate by the formula above, an alternative formula that takes race into account (Chronic Kidney Disease Epidemiology Collaboration CKD-EPI formula) should be used for calculating the related estimated glomerular filtration rate (GFR) with a correction factor for African American race creatinine clearance for trial eligibility, where GFR \>= 30 mL/min/1.73m\^2 will be considered adequate * Total bilirubin: 1.5 =\< institutional upper limit of normal (ULN) (within 120 days prior to registration) (Note: In subjects with Gilbert's syndrome, if total bilirubin is \> 1.5 x ULN, measure direct and indirect bilirubin. If direct bilirubin is less than or equal to 1.5 x ULN, subject is eligible) * Aspartate aminotransferase (AST)(serum glutamic-oxaloacetic transaminase \[SGOT\]) and alanine aminotransferase (ALT)(serum glutamate pyruvate transaminase \[SGPT\]): =\< 2.5 x institutional ULN (within 120 days prior to registration) * Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial; Note: HIV testing is not required for eligibility for this protocol * For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated. * Note: Known positive test for hepatitis B virus surface antigen (HBV sAg) indicating acute or chronic infection would make the patient ineligible unless the viral load becomes undetectable on suppressive therapy. Patients who are immune to hepatitis B (anti-Hepatitis B surface antibody positive) are eligible (e.g. patients immunized against hepatitis B) * For patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load * Note: Known positive test for hepatitis C virus ribonucleic acid (HCV RNA) indicating acute or chronic infection would make the patient ineligible unless the viral load becomes undetectable on suppressive therapy * The patient or a legally authorized representative must provide study-specific informed consent prior to study entry and, for patients treated in the United States (U.S.), authorization permitting release of personal health information	* Previous radical surgery (prostatectomy) or any form of curative-intent ablation whether focal or whole-gland (e.g., cryosurgery, high intensity focused ultrasound \[HIFU\], laser thermal ablation, etc.) for prostate cancer * Definitive clinical or radiologic evidence of metastatic disease (M1) * Prior invasive malignancy (except non-melanomatous skin cancer) unless disease free for a minimum of 3 years. History of or current diagnosis of hematologic malignancy is not allowed * Prior radiotherapy to the prostate/pelvis region that would result in overlap of radiation therapy fields * Previous bilateral orchiectomy * Previous hormonal therapy, such as luteinizing hormone-releasing hormone (LHRH) agonists (e.g., leuprolide, goserelin, buserelin, triptorelin) or LHRH antagonist (e.g. degarelix), anti-androgens (e.g., flutamide, bicalutamide, cyproterone acetate). ADT started prior to study registration is not allowed * Prior use of 5-alpha-reductase inhibitors is allowed, however, it must be stopped prior to enrollment on the study with at least a 30 day washout period before baseline study PSA measure and registration * Active testosterone replacement therapy; any replacement therapy must be stopped at least 30 days prior to registration * Severe, active co-morbidity defined as follows: * Current severe or unstable angina; * New York Heart Association Functional Classification III/IV (Note: Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification) * History of any condition that in the opinion of the investigator, would preclude participation in this study * Inability to swallow oral pills * High risk features, which includes any of the following: * Gleason 8-10 \[ISUP Grade Group 4-5\] * PSA \> 20 * cT3-4 by digital exam OR gross extra-prostatic extension on imaging \[indeterminate MRI evidence will not count and the patient will be eligible\]

Inclusion Criteria

Exclusion Criteria

* Pathologically (histologically or cytologically) proven diagnosis of adenocarcinoma of the prostate within 270 days prior to registration
* Unfavorable intermediate risk prostate cancer, defined as having ALL the following bulleted criteria:
* Has at least one intermediate risk factor (IRF):
* PSA 10-20 ng/mL
* Clinical stage T2b-c (digital rectal examination \[DRE\] and/or imaging) by American Joint Committee on Cancer (AJCC) 8th edition
* Gleason score 7 (Gleason 3+4 or 4+3 \[ International Society of Urological Pathology (ISUP) Grade Group 2-3\])
* Has ONE or more of the following 'unfavorable' intermediate-risk designators:
* \> 1 immature reticulocyte fraction (IRF)
* Gleason 4+3=7 (ISUP Grade Group 3)
* \>= 50% of biopsy cores positive
* Biopsies may include 'sextant' sampling of right/left regions of the prostate, often labeled base, mid-gland and apex. All such 'sextant' biopsy cores should be counted. Men may also undergo 'targeted' sampling of prostate lesions (guided by MRI, ultrasound or other approaches). A targeted lesion that is biopsied more than once and demonstrates cancer (regardless of number of targeted cores involved) should count as a single additional positive core sampled and positive. In cases of uncertainty, count the biopsy sampling as sextant core(s)
* Absence of high-risk features
* Appropriate stage for study entry based on the following diagnostic workup:
* History/physical examination within 120 days prior to registration;
* Negative bone imaging (M0) within 120 days prior to registration; Note: Tc-99m bone scan or sodium fluoride (NaF) positron emission tomography (PET) are allowed. Equivocal bone scan findings are allowed if plain films X-ray, computed tomography (CT) or magnetic resonance imaging (MRI) are negative for metastasis at the concerned site(s). While a negative fluciclovine, choline, or prostate specific membrane antigen (PSMA) PET may be counted as acceptable substitute for bone imaging, any suspicious findings must be confirmed and correlated with conventional imaging (Tc-99m bone scan, NaF PET, CT, X-ray, or MRI) to determine eligibility based on the latter modalities (e.g. M0 based on conventional imaging modalities)
* Clinically negative lymph nodes (N0) as established by conventional imaging (pelvic +/- abdominal CT or MR), within 120 days prior to registration. Patients with lymph nodes equivocal or questionable by imaging are eligible if the nodes are =\< 1.0 cm in short axis and/or if biopsy is negative.
* Age \>= 18
* Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 within 120 days prior to registration
* Non-castrate testosterone level (\> 50 ng/dL) within 120 days prior to registration
* Absolute neutrophil \>= 1,000 cells/mm\^3 (within 120 days prior to registration)
* Hemoglobin \>= 8.0 g/dL, independent of transfusion and/or growth factors (within 120 days prior to registration)
* Platelet count \>= 100,000 cells/mm\^3 independent of transfusion and/or growth factors (within 120 days prior to registration)
* Creatinine clearance (CrCl) \>= 30 mL/min estimated by Cockcroft-Gault equation (within 120 days prior to registration)
* For African American patients specifically whose renal function is not considered adequate by the formula above, an alternative formula that takes race into account (Chronic Kidney Disease Epidemiology Collaboration CKD-EPI formula) should be used for calculating the related estimated glomerular filtration rate (GFR) with a correction factor for African American race creatinine clearance for trial eligibility, where GFR \>= 30 mL/min/1.73m\^2 will be considered adequate
* Total bilirubin: 1.5 =\< institutional upper limit of normal (ULN) (within 120 days prior to registration) (Note: In subjects with Gilbert's syndrome, if total bilirubin is \> 1.5 x ULN, measure direct and indirect bilirubin. If direct bilirubin is less than or equal to 1.5 x ULN, subject is eligible)
* Aspartate aminotransferase (AST)(serum glutamic-oxaloacetic transaminase \[SGOT\]) and alanine aminotransferase (ALT)(serum glutamate pyruvate transaminase \[SGPT\]): =\< 2.5 x institutional ULN (within 120 days prior to registration)
* Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial; Note: HIV testing is not required for eligibility for this protocol
* For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated.
* Note: Known positive test for hepatitis B virus surface antigen (HBV sAg) indicating acute or chronic infection would make the patient ineligible unless the viral load becomes undetectable on suppressive therapy. Patients who are immune to hepatitis B (anti-Hepatitis B surface antibody positive) are eligible (e.g. patients immunized against hepatitis B)
* For patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load
* Note: Known positive test for hepatitis C virus ribonucleic acid (HCV RNA) indicating acute or chronic infection would make the patient ineligible unless the viral load becomes undetectable on suppressive therapy
* The patient or a legally authorized representative must provide study-specific informed consent prior to study entry and, for patients treated in the United States (U.S.), authorization permitting release of personal health information

* Previous radical surgery (prostatectomy) or any form of curative-intent ablation whether focal or whole-gland (e.g., cryosurgery, high intensity focused ultrasound \[HIFU\], laser thermal ablation, etc.) for prostate cancer
* Definitive clinical or radiologic evidence of metastatic disease (M1)
* Prior invasive malignancy (except non-melanomatous skin cancer) unless disease free for a minimum of 3 years. History of or current diagnosis of hematologic malignancy is not allowed
* Prior radiotherapy to the prostate/pelvis region that would result in overlap of radiation therapy fields
* Previous bilateral orchiectomy
* Previous hormonal therapy, such as luteinizing hormone-releasing hormone (LHRH) agonists (e.g., leuprolide, goserelin, buserelin, triptorelin) or LHRH antagonist (e.g. degarelix), anti-androgens (e.g., flutamide, bicalutamide, cyproterone acetate). ADT started prior to study registration is not allowed
* Prior use of 5-alpha-reductase inhibitors is allowed, however, it must be stopped prior to enrollment on the study with at least a 30 day washout period before baseline study PSA measure and registration
* Active testosterone replacement therapy; any replacement therapy must be stopped at least 30 days prior to registration
* Severe, active co-morbidity defined as follows:
* Current severe or unstable angina;
* New York Heart Association Functional Classification III/IV (Note: Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification)
* History of any condition that in the opinion of the investigator, would preclude participation in this study
* Inability to swallow oral pills
* High risk features, which includes any of the following:
* Gleason 8-10 \[ISUP Grade Group 4-5\]
* PSA \> 20
* cT3-4 by digital exam OR gross extra-prostatic extension on imaging \[indeterminate MRI evidence will not count and the patient will be eligible\]

Contacts and Locations

Principal Investigator

Neil B Desai

PRINCIPAL_INVESTIGATOR

NRG Oncology

Study Locations (Sites)

University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, 35233

United States

Banner MD Anderson Cancer Center

Gilbert, Arizona, 85234

United States

Arizona Center for Cancer Care - Gilbert

Gilbert, Arizona, 85297

United States

Arizona Center for Cancer Care-Peoria

Peoria, Arizona, 85381

United States

Arizona Center for Cancer Care - Phoenix

Phoenix, Arizona, 85027

United States

Arizona Center for Cancer Care - Scottsdale

Scottsdale, Arizona, 85258

United States

Arizona Center for Cancer Care-Surprise

Surprise, Arizona, 85374

United States

University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205

United States

Sutter Cancer Centers Radiation Oncology Services-Auburn

Auburn, California, 95603

United States

AIS Cancer Center at San Joaquin Community Hospital

Bakersfield, California, 93301

United States

Tower Cancer Research Foundation

Beverly Hills, California, 90211

United States

Sutter Cancer Centers Radiation Oncology Services-Cameron Park

Cameron Park, California, 95682

United States

City of Hope Corona

Corona, California, 92882

United States

City of Hope Comprehensive Cancer Center

Duarte, California, 91010

United States

Kaiser Permanente Dublin

Dublin, California, 94568

United States

UC San Diego Health System - Encinitas

Encinitas, California, 92024

United States

Kaiser Permanente-Fremont

Fremont, California, 94538

United States

Washington Hospital

Fremont, California, 94538

United States

Kaiser Permanente-Fresno

Fresno, California, 93720

United States

Marin General Hospital

Greenbrae, California, 94904

United States

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care

Irvine, California, 92612

United States

City of Hope at Irvine Lennar

Irvine, California, 92618

United States

UC San Diego Moores Cancer Center

La Jolla, California, 92093

United States

City of Hope Antelope Valley

Lancaster, California, 93534

United States

Los Angeles General Medical Center

Los Angeles, California, 90033

United States

USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033

United States

Cedars Sinai Medical Center

Los Angeles, California, 90048

United States

Fremont - Rideout Cancer Center

Marysville, California, 95901

United States

Memorial Medical Center

Modesto, California, 95355

United States

Kaiser Permanente-Modesto

Modesto, California, 95356

United States

Providence Queen of The Valley

Napa, California, 94558

United States

Kaiser Permanente-Oakland

Oakland, California, 94611

United States

Saint Joseph Hospital - Orange

Orange, California, 92868

United States

UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California, 92868

United States

Palo Alto Medical Foundation Health Care

Palo Alto, California, 94301

United States

Kaiser Permanente-Roseville

Roseville, California, 95661

United States

Sutter Cancer Centers Radiation Oncology Services-Roseville

Roseville, California, 95661

United States

Kaiser Permanente Downtown Commons

Sacramento, California, 95814

United States

Sutter Medical Center Sacramento

Sacramento, California, 95816

United States

University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817

United States

Kaiser Permanente-South Sacramento

Sacramento, California, 95823

United States

California Protons Cancer Therapy Center

San Diego, California, 92121

United States

Kaiser Permanente-San Francisco

San Francisco, California, 94115

United States

UCSF Medical Center-Mission Bay

San Francisco, California, 94158

United States

Kaiser Permanente-Santa Teresa-San Jose

San Jose, California, 95119

United States

Kaiser Permanente San Leandro

San Leandro, California, 94577

United States

Ridley-Tree Cancer Center

Santa Barbara, California, 93105

United States

Kaiser Permanente Medical Center - Santa Clara

Santa Clara, California, 95051

United States

Kaiser Permanente-Santa Rosa

Santa Rosa, California, 95403

United States

City of Hope South Pasadena

South Pasadena, California, 91030

United States

Kaiser Permanente-South San Francisco

South San Francisco, California, 94080

United States

Palo Alto Medical Foundation-Sunnyvale

Sunnyvale, California, 94086

United States

Cedars-Sinai Cancer - Tarzana

Tarzana, California, 91356

United States

City of Hope South Bay

Torrance, California, 90503

United States

Torrance Memorial Physician Network - Cancer Care

Torrance, California, 90505

United States

Torrance Memorial Medical Center

Torrance, California, 90509

United States

Gene Upshaw Memorial Tahoe Forest Cancer Center

Truckee, California, 96161

United States

City of Hope Upland

Upland, California, 91786

United States

Kaiser Permanente-Vallejo

Vallejo, California, 94589

United States

Sutter Solano Medical Center/Cancer Center

Vallejo, California, 94589

United States

Kaiser Permanente-Walnut Creek

Walnut Creek, California, 94596

United States

UCHealth University of Colorado Hospital

Aurora, Colorado, 80045

United States

Rocky Mountain Cancer Centers-Boulder

Boulder, Colorado, 80304

United States

UCHealth Memorial Hospital Central

Colorado Springs, Colorado, 80909

United States

Memorial Hospital North

Colorado Springs, Colorado, 80920

United States

Shaw Cancer Center

Edwards, Colorado, 81632

United States

Poudre Valley Hospital

Fort Collins, Colorado, 80524

United States

Cancer Care and Hematology-Fort Collins

Fort Collins, Colorado, 80528

United States

Banner North Colorado Medical Center

Greeley, Colorado, 80631

United States

UCHealth Greeley Hospital

Greeley, Colorado, 80631

United States

UCHealth Highlands Ranch Hospital

Highlands Ranch, Colorado, 80129

United States

Medical Center of the Rockies

Loveland, Colorado, 80538

United States

Banner McKee Medical Center

Loveland, Colorado, 80539

United States

Hartford HealthCare - Saint Vincent's Medical Center

Bridgeport, Connecticut, 06606

United States

Smilow Cancer Hospital Care Center at Greenwich

Greenwich, Connecticut, 06830

United States

Smilow Cancer Hospital Care Center - Guilford

Guilford, Connecticut, 06437

United States

Hartford Hospital

Hartford, Connecticut, 06102

United States

Midstate Medical Center

Meriden, Connecticut, 06451

United States

The Hospital of Central Connecticut

New Britain, Connecticut, 06050

United States

Yale University

New Haven, Connecticut, 06520

United States

Norwalk Hospital

Norwalk, Connecticut, 06856

United States

Smilow Cancer Hospital Care Center-Trumbull

Trumbull, Connecticut, 06611

United States

Smilow Cancer Hospital Care Center - Waterford

Waterford, Connecticut, 06385

United States

Beebe South Coastal Health Campus

Millville, Delaware, 19967

United States

Helen F Graham Cancer Center

Newark, Delaware, 19713

United States

Medical Oncology Hematology Consultants PA

Newark, Delaware, 19713

United States

Beebe Health Campus

Rehoboth Beach, Delaware, 19971

United States

George Washington University Medical Center

Washington, District of Columbia, 20037

United States

Veterans Administration Hospital

Bay Pines, Florida, 33744

United States

Boca Raton Regional Hospital

Boca Raton, Florida, 33486

United States

University of Florida Health Science Center - Gainesville

Gainesville, Florida, 32610

United States

Jupiter Medical Center

Jupiter, Florida, 33458

United States

GenesisCare USA - Plantation

Plantation, Florida, 33324

United States

Cleveland Clinic-Weston

Weston, Florida, 33331

United States

Grady Health System

Atlanta, Georgia, 30303

United States

Emory Proton Therapy Center

Atlanta, Georgia, 30308

United States

Emory University Hospital Midtown

Atlanta, Georgia, 30308

United States

Piedmont Hospital

Atlanta, Georgia, 30309

United States

Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322

United States

Emory Saint Joseph's Hospital

Atlanta, Georgia, 30342

United States

Piedmont Fayette Hospital

Fayetteville, Georgia, 30214

United States

Northeast Georgia Medical Center-Gainesville

Gainesville, Georgia, 30501

United States

Emory Johns Creek Hospital

Johns Creek, Georgia, 30097

United States

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, 31405

United States

Saint Luke's Cancer Institute - Boise

Boise, Idaho, 83712

United States

Saint Luke's Cancer Institute - Fruitland

Fruitland, Idaho, 83619

United States

Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, 83642

United States

Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, 83687

United States

Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, 83301

United States

Alton Memorial Hospital

Alton, Illinois, 62002

United States

Rush - Copley Medical Center

Aurora, Illinois, 60504

United States

Advocate Good Shepherd Hospital

Barrington, Illinois, 60010

United States

Illinois CancerCare-Bloomington

Bloomington, Illinois, 61704

United States

Illinois CancerCare-Canton

Canton, Illinois, 61520

United States

Illinois CancerCare-Carthage

Carthage, Illinois, 62321

United States

Northwestern University

Chicago, Illinois, 60611

United States

Rush University Medical Center

Chicago, Illinois, 60612

United States

University of Illinois

Chicago, Illinois, 60612

United States

Advocate Illinois Masonic Medical Center

Chicago, Illinois, 60657

United States

AMG Crystal Lake - Oncology

Crystal Lake, Illinois, 60014

United States

Carle at The Riverfront

Danville, Illinois, 61832

United States

Decatur Memorial Hospital

Decatur, Illinois, 62526

United States

Northwestern Medicine Cancer Center Kishwaukee

DeKalb, Illinois, 60115

United States

Advocate Good Samaritan Hospital

Downers Grove, Illinois, 60515

United States

Crossroads Cancer Center

Effingham, Illinois, 62401

United States

Advocate Sherman Hospital

Elgin, Illinois, 60123

United States

Elmhurst Memorial Hospital

Elmhurst, Illinois, 60126

United States

Illinois CancerCare-Eureka

Eureka, Illinois, 61530

United States

Illinois CancerCare-Galesburg

Galesburg, Illinois, 61401

United States

Northwestern Medicine Cancer Center Delnor

Geneva, Illinois, 60134

United States

Northwestern Medicine Glenview Outpatient Center

Glenview, Illinois, 60026

United States

Northwestern Medicine Grayslake Outpatient Center

Grayslake, Illinois, 60030

United States

Advocate South Suburban Hospital

Hazel Crest, Illinois, 60429

United States

Edward Hines Jr VA Hospital

Hines, Illinois, 60141

United States

Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, 61443

United States

Northwestern Medicine Lake Forest Hospital

Lake Forest, Illinois, 60045

United States

AMG Libertyville - Oncology

Libertyville, Illinois, 60048

United States

Condell Memorial Hospital

Libertyville, Illinois, 60048

United States

Illinois CancerCare-Macomb

Macomb, Illinois, 61455

United States

Carle Physician Group-Mattoon/Charleston

Mattoon, Illinois, 61938

United States

Loyola University Medical Center

Maywood, Illinois, 60153

United States

Edward Hospital/Cancer Center

Naperville, Illinois, 60540

United States

HSHS Saint Elizabeth's Hospital

O'Fallon, Illinois, 62269

United States

Advocate Christ Medical Center

Oak Lawn, Illinois, 60453-2699

United States

Northwestern Medicine Orland Park

Orland Park, Illinois, 60462

United States

Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, 61350

United States

Advocate High Tech Medical Park

Palos Heights, Illinois, 60463

United States

Advocate Lutheran General Hospital

Park Ridge, Illinois, 60068

United States

Illinois CancerCare-Pekin

Pekin, Illinois, 61554

United States

Illinois CancerCare-Peoria

Peoria, Illinois, 61615

United States

Methodist Medical Center of Illinois

Peoria, Illinois, 61636

United States

OSF Saint Francis Medical Center

Peoria, Illinois, 61637

United States

Illinois CancerCare-Peru

Peru, Illinois, 61354

United States

Illinois CancerCare-Princeton

Princeton, Illinois, 61356

United States

UW Health Carbone Cancer Center Rockford

Rockford, Illinois, 61114

United States

Memorial Hospital East

Shiloh, Illinois, 62269

United States

Springfield Memorial Hospital

Springfield, Illinois, 62781

United States

Carle Cancer Center

Urbana, Illinois, 61801

United States

Northwestern Medicine Cancer Center Warrenville

Warrenville, Illinois, 60555

United States

Illinois CancerCare - Washington

Washington, Illinois, 61571

United States

Saint Luke's Hospital

Cedar Rapids, Iowa, 52402

United States

Mercy Hospital

Cedar Rapids, Iowa, 52403

United States

Iowa Methodist Medical Center

Des Moines, Iowa, 50309

United States

University of Kansas Cancer Center

Kansas City, Kansas, 66160

United States

The University of Kansas Cancer Center - Olathe

Olathe, Kansas, 66061

United States

University of Kansas Cancer Center-Overland Park

Overland Park, Kansas, 66210

United States

University of Kansas Hospital-Indian Creek Campus

Overland Park, Kansas, 66211

United States

Salina Regional Health Center

Salina, Kansas, 67401

United States

Cotton O'Neil Cancer Center / Stormont Vail Health

Topeka, Kansas, 66606

United States

University of Kansas Health System Saint Francis Campus

Topeka, Kansas, 66606

United States

University of Kansas Hospital-Westwood Cancer Center

Westwood, Kansas, 66205

United States

Ascension Via Christi Hospitals Wichita

Wichita, Kansas, 67214

United States

Saint Joseph Radiation Oncology Resource Center

Lexington, Kentucky, 40504

United States

Mary Bird Perkins Cancer Center - Metairie

Metairie, Louisiana, 70002

United States

East Jefferson General Hospital

Metairie, Louisiana, 70006

United States

LSU Healthcare Network / Metairie Multi-Specialty Clinic

Metairie, Louisiana, 70006

United States

Maine Medical Center-Bramhall Campus

Portland, Maine, 04102

United States

Penobscot Bay Medical Center

Rockport, Maine, 04856

United States

Maine Medical Center- Scarborough Campus

Scarborough, Maine, 04074

United States

Maine Medical Partners - South Portland

South Portland, Maine, 04106

United States

Luminis Health Anne Arundel Medical Center

Annapolis, Maryland, 21401

United States

Maryland Proton Treatment Center

Baltimore, Maryland, 21201

United States

University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, 21201

United States

UM Upper Chesapeake Medical Center

Bel Air, Maryland, 21014

United States

University of Maryland Shore Medical Center at Easton

Easton, Maryland, 21601

United States

UM Baltimore Washington Medical Center/Tate Cancer Center

Glen Burnie, Maryland, 21061

United States

UM Capital Region Medical Center

Largo, Maryland, 20774

United States

TidalHealth Richard A Henson Cancer Institute

Ocean Pines, Maryland, 21811

United States

TidalHealth Peninsula Regional

Salisbury, Maryland, 21801

United States

Beverly Hospital

Beverly, Massachusetts, 01915

United States

Lahey Hospital and Medical Center

Burlington, Massachusetts, 01805

United States

Addison Gilbert Hospital

Gloucester, Massachusetts, 01930

United States

Lahey Medical Center-Peabody

Peabody, Massachusetts, 01960

United States

Winchester Hospital

Winchester, Massachusetts, 01890

United States

Veteran's Administration Medical Center - Ann Arbor

Ann Arbor, Michigan, 48105

United States

Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Ann Arbor, Michigan, 48106

United States

University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, 48109

United States

McLaren Cancer Institute-Bay City

Bay City, Michigan, 48706

United States

Trinity Health IHA Medical Group Hematology Oncology - Brighton

Brighton, Michigan, 48114

United States

Trinity Health Medical Center - Brighton

Brighton, Michigan, 48114

United States

Henry Ford Cancer Institute-Downriver

Brownstown, Michigan, 48183

United States

Trinity Health IHA Medical Group Hematology Oncology - Canton

Canton, Michigan, 48188

United States

Trinity Health Medical Center - Canton

Canton, Michigan, 48188

United States

Chelsea Hospital

Chelsea, Michigan, 48118

United States

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

Chelsea, Michigan, 48118

United States

McLaren Cancer Institute-Clarkston

Clarkston, Michigan, 48346

United States

Michigan Healthcare Professionals Clarkston

Clarkston, Michigan, 48346

United States

Henry Ford Macomb Hospital-Clinton Township

Clinton Township, Michigan, 48038

United States

Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201

United States

Henry Ford Hospital

Detroit, Michigan, 48202

United States

Michigan Healthcare Professionals Farmington

Farmington Hills, Michigan, 48334

United States

Weisberg Cancer Treatment Center

Farmington Hills, Michigan, 48334

United States

Genesys Hurley Cancer Institute

Flint, Michigan, 48503

United States

McLaren Cancer Institute-Flint

Flint, Michigan, 48532

United States

Trinity Health Grand Rapids Hospital

Grand Rapids, Michigan, 49503

United States

Bronson Methodist Hospital

Kalamazoo, Michigan, 49007

United States

West Michigan Cancer Center

Kalamazoo, Michigan, 49007

United States

Karmanos Cancer Institute at McLaren Greater Lansing

Lansing, Michigan, 48910

United States

University of Michigan Health - Sparrow Lansing

Lansing, Michigan, 48912

United States

McLaren Cancer Institute-Lapeer Region

Lapeer, Michigan, 48446

United States

Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, Michigan, 48154

United States

Michigan Healthcare Professionals Macomb

Macomb, Michigan, 48044

United States

Michigan Healthcare Professionals Madison Heights

Madison Heights, Michigan, 48071

United States

McLaren Cancer Institute-Macomb

Mount Clemens, Michigan, 48043

United States

McLaren Cancer Institute-Central Michigan

Mount Pleasant, Michigan, 48858

United States

Corewell Health Lakeland Hospitals - Niles Hospital

Niles, Michigan, 49120

United States

Henry Ford Medical Center-Columbus

Novi, Michigan, 48377

United States

McLaren Cancer Institute-Northern Michigan

Petoskey, Michigan, 49770

United States

Trinity Health Saint Joseph Mercy Oakland Hospital

Pontiac, Michigan, 48341

United States

McLaren-Port Huron

Port Huron, Michigan, 48060

United States

Corewell Health William Beaumont University Hospital

Royal Oak, Michigan, 48073

United States

MyMichigan Medical Center Saginaw

Saginaw, Michigan, 48601

United States

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center

Saint Joseph, Michigan, 49085

United States

Corewell Health Lakeland Hospitals - Saint Joseph Hospital

Saint Joseph, Michigan, 49085

United States

MyMichigan Medical Center Tawas

Tawas City, Michigan, 48764

United States

Munson Medical Center

Traverse City, Michigan, 49684

United States

Corewell Health Beaumont Troy Hospital

Troy, Michigan, 48085

United States

Michigan Healthcare Professionals Troy

Troy, Michigan, 48098

United States

Henry Ford West Bloomfield Hospital

West Bloomfield, Michigan, 48322

United States

University of Michigan Health - West

Wyoming, Michigan, 49519

United States

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

Ypsilanti, Michigan, 48197

United States

Miller-Dwan Hospital

Duluth, Minnesota, 55805

United States

Saint Luke's Hospital of Duluth

Duluth, Minnesota, 55805

United States

Hennepin County Medical Center

Minneapolis, Minnesota, 55415

United States

Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416

United States

Regions Hospital

Saint Paul, Minnesota, 55101

United States

Saint Francis Medical Center

Cape Girardeau, Missouri, 63703

United States

MU Health - University Hospital/Ellis Fischel Cancer Center

Columbia, Missouri, 65212

United States

Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, 63141

United States

Parkland Health Center - Farmington

Farmington, Missouri, 63640

United States

University of Kansas Cancer Center - North

Kansas City, Missouri, 64154

United States

University of Kansas Cancer Center - Lee's Summit

Lee's Summit, Missouri, 64064

United States

University of Kansas Cancer Center at North Kansas City Hospital

North Kansas City, Missouri, 64116

United States

Delbert Day Cancer Institute at PCRMC

Rolla, Missouri, 65401

United States

SSM Health Saint Louis University Hospital

Saint Louis, Missouri, 63104

United States

Washington University School of Medicine

Saint Louis, Missouri, 63110

United States

Siteman Cancer Center-South County

Saint Louis, Missouri, 63129

United States

Missouri Baptist Medical Center

Saint Louis, Missouri, 63131

United States

Siteman Cancer Center at Christian Hospital

Saint Louis, Missouri, 63136

United States

Siteman Cancer Center at Saint Peters Hospital

Saint Peters, Missouri, 63376

United States

Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, 63670

United States

Mercy Hospital Springfield

Springfield, Missouri, 65804

United States

Missouri Baptist Sullivan Hospital

Sullivan, Missouri, 63080

United States

BJC Outpatient Center at Sunset Hills

Sunset Hills, Missouri, 63127

United States

Billings Clinic Cancer Center

Billings, Montana, 59101

United States

Saint James Community Hospital and Cancer Treatment Center

Butte, Montana, 59701

United States

Benefis Sletten Cancer Institute

Great Falls, Montana, 59405

United States

Nebraska Medicine-Bellevue

Bellevue, Nebraska, 68123

United States

Nebraska Medicine-Village Pointe

Omaha, Nebraska, 68118

United States

University of Nebraska Medical Center

Omaha, Nebraska, 68198

United States

New Hampshire Oncology Hematology PA-Concord

Concord, New Hampshire, 03301

United States

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, New Hampshire, 03756

United States

Solinsky Center for Cancer Care

Manchester, New Hampshire, 03103

United States

Memorial Sloan Kettering Basking Ridge

Basking Ridge, New Jersey, 07920

United States

Clara Maass Medical Center

Belleville, New Jersey, 07109

United States

Cooper Hospital University Medical Center

Camden, New Jersey, 08103

United States

AtlantiCare Surgery Center

Egg Harbor Township, New Jersey, 08234

United States

Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus

Elizabeth, New Jersey, 07207

United States

The Cancer Institute of New Jersey Hamilton

Hamilton, New Jersey, 08690

United States

Jersey City Medical Center

Jersey City, New Jersey, 07302

United States

Saint Barnabas Medical Center

Livingston, New Jersey, 07039

United States

Memorial Sloan Kettering Monmouth

Middletown, New Jersey, 07748

United States

Memorial Sloan Kettering Bergen

Montvale, New Jersey, 07645

United States

Cooper CyberKnife Center

Mount Laurel, New Jersey, 08054

United States

Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903

United States

Rutgers New Jersey Medical School

Newark, New Jersey, 07101

United States

Newark Beth Israel Medical Center

Newark, New Jersey, 07112

United States

The Valley Hospital - Luckow Pavilion

Paramus, New Jersey, 07652

United States

Sidney Kimmel Cancer Center Washington Township

Sewell, New Jersey, 08080

United States

Robert Wood Johnson University Hospital Somerset

Somerville, New Jersey, 08876

United States

Community Medical Center

Toms River, New Jersey, 08755

United States

MD Anderson Cancer Center at Cooper-Voorhees

Voorhees, New Jersey, 08043

United States

Lovelace Medical Center-Saint Joseph Square

Albuquerque, New Mexico, 87102

United States

University of New Mexico Cancer Center

Albuquerque, New Mexico, 87106

United States

Lovelace Radiation Oncology

Albuquerque, New Mexico, 87109

United States

Presbyterian Kaseman Hospital

Albuquerque, New Mexico, 87110

United States

Presbyterian Rust Medical Center/Jorgensen Cancer Center

Rio Rancho, New Mexico, 87124

United States

Northwell Health Imbert Cancer Center

Bay Shore, New York, 11706

United States

Montefiore Medical Center-Einstein Campus

Bronx, New York, 10461

United States

Montefiore Medical Center - Moses Campus

Bronx, New York, 10467

United States

New York-Presbyterian/Brooklyn Methodist Hospital

Brooklyn, New York, 11215

United States

Roswell Park Cancer Institute

Buffalo, New York, 14263

United States

Memorial Sloan Kettering Commack

Commack, New York, 11725

United States

Mary Imogene Bassett Hospital

Cooperstown, New York, 13326

United States

Noyes Memorial Hospital/Myers Cancer Center

Dansville, New York, 14437

United States

Arnot Ogden Medical Center/Falck Cancer Center

Elmira, New York, 14905

United States

The New York Hospital Medical Center of Queens

Flushing, New York, 11355

United States

Northwell Health Physicians Partners Radiation Medicine at Queens

Forest Hills, New York, 11375

United States

Glens Falls Hospital

Glens Falls, New York, 12801

United States

Northwell Health Cancer Institute at Huntington

Greenlawn, New York, 11740

United States

Memorial Sloan Kettering Westchester

Harrison, New York, 10604

United States

Northwell Health/Center for Advanced Medicine

Lake Success, New York, 11042

United States

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York, New York, 10032

United States

Manhattan Eye Ear and Throat Hospital

New York, New York, 10065

United States

Memorial Sloan Kettering Cancer Center

New York, New York, 10065

United States

Lenox Hill Hospital

New York, New York, 10075

United States

Queens Cancer Center

Rego Park, New York, 11374

United States

Highland Hospital

Rochester, New York, 14620

United States

University of Rochester

Rochester, New York, 14642

United States

Phelps Memorial Hospital Center

Sleepy Hollow, New York, 10591

United States

Staten Island University Hospital

Staten Island, New York, 10305

United States

Stony Brook University Medical Center

Stony Brook, New York, 11794

United States

State University of New York Upstate Medical University

Syracuse, New York, 13210

United States

Memorial Sloan Kettering Nassau

Uniondale, New York, 11553

United States

Westchester Medical Center

Valhalla, New York, 10595

United States

Wilmot Cancer Institute at Webster

Webster, New York, 14580

United States

Mission Hospital

Asheville, North Carolina, 28801

United States

Duke Cancer Institute Cary

Cary, North Carolina, 27518

United States

UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599

United States

Durham VA Medical Center

Durham, North Carolina, 27705

United States

Duke University Medical Center

Durham, North Carolina, 27710

United States

UNC Rex Healthcare

Raleigh, North Carolina, 27607

United States

Duke Raleigh Hospital

Raleigh, North Carolina, 27609

United States

UNC Rex Cancer Center of Wakefield

Raleigh, North Carolina, 27614

United States

Novant Cancer Institute Radiation Oncology - Supply

Supply, North Carolina, 28462

United States

Novant Health Cancer Institute Radiation Oncology - Wilmington

Wilmington, North Carolina, 28401

United States

Novant Health New Hanover Regional Medical Center

Wilmington, North Carolina, 28401

United States

Sanford Bismarck Medical Center

Bismarck, North Dakota, 58501

United States

Sanford Broadway Medical Center

Fargo, North Dakota, 58122

United States

Sanford Roger Maris Cancer Center

Fargo, North Dakota, 58122

United States

Altru Cancer Center

Grand Forks, North Dakota, 58201

United States

Summa Health System - Akron Campus

Akron, Ohio, 44304

United States

Cleveland Clinic Akron General

Akron, Ohio, 44307

United States

UH Seidman Cancer Center at UH Avon Health Center

Avon, Ohio, 44011

United States

Summa Health System - Barberton Campus

Barberton, Ohio, 44203

United States

UHHS-Chagrin Highlands Medical Center

Beachwood, Ohio, 44122

United States

Aultman Health Foundation

Canton, Ohio, 44710

United States

Adena Regional Medical Center

Chillicothe, Ohio, 45601

United States

University of Cincinnati Cancer Center-UC Medical Center

Cincinnati, Ohio, 45219

United States

Case Western Reserve University

Cleveland, Ohio, 44106

United States

MetroHealth Medical Center

Cleveland, Ohio, 44109

United States

Cleveland Clinic Cancer Center/Fairview Hospital

Cleveland, Ohio, 44111

United States

Cleveland Clinic Foundation

Cleveland, Ohio, 44195

United States

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210

United States

Riverside Methodist Hospital

Columbus, Ohio, 43214

United States

Grant Medical Center

Columbus, Ohio, 43215

United States

Doctors Hospital

Columbus, Ohio, 43228

United States

Delaware Health Center-Grady Cancer Center

Delaware, Ohio, 43015

United States

Dublin Methodist Hospital

Dublin, Ohio, 43016

United States

OhioHealth Mansfield Hospital

Mansfield, Ohio, 44903

United States

Cleveland Clinic Cancer Center Mansfield

Mansfield, Ohio, 44906

United States

OhioHealth Marion General Hospital

Marion, Ohio, 43302

United States

Hillcrest Hospital Cancer Center

Mayfield Heights, Ohio, 44124

United States

Summa Health Medina Medical Center

Medina, Ohio, 44256

United States

UH Seidman Cancer Center at Lake Health Mentor Campus

Mentor, Ohio, 44060

United States

UH Seidman Cancer Center at Southwest General Hospital

Middleburg Heights, Ohio, 44130

United States

University Hospitals Parma Medical Center

Parma, Ohio, 44129

United States

University Hospitals Portage Medical Center

Ravenna, Ohio, 44266

United States

North Coast Cancer Care

Sandusky, Ohio, 44870

United States

UH Seidman Cancer Center at Firelands Regional Medical Center

Sandusky, Ohio, 44870

United States

Cleveland Clinic Cancer Center Strongsville

Strongsville, Ohio, 44136

United States

ProMedica Flower Hospital

Sylvania, Ohio, 43560

United States

South Pointe Hospital

Warrensville Heights, Ohio, 44122

United States

University of Cincinnati Cancer Center-West Chester

West Chester, Ohio, 45069

United States

Cleveland Clinic Wooster Family Health and Surgery Center

Wooster, Ohio, 44691

United States

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104

United States

Saint Charles Health System

Bend, Oregon, 97701

United States

Legacy Mount Hood Medical Center

Gresham, Oregon, 97030

United States

Legacy Good Samaritan Hospital and Medical Center

Portland, Oregon, 97210

United States

Providence Portland Medical Center

Portland, Oregon, 97213

United States

Oregon Health and Science University

Portland, Oregon, 97239

United States

Legacy Meridian Park Hospital

Tualatin, Oregon, 97062

United States

Saint Luke's Cancer Center - Allentown

Allentown, Pennsylvania, 18104

United States

UPMC Altoona

Altoona, Pennsylvania, 16601

United States

UPMC-Heritage Valley Health System Beaver

Beaver, Pennsylvania, 15009

United States

Saint Luke's University Hospital-Bethlehem Campus

Bethlehem, Pennsylvania, 18015

United States

Crozer-Keystone Regional Cancer Center at Broomall

Broomall, Pennsylvania, 19008

United States

Carlisle Regional Cancer Center

Carlisle, Pennsylvania, 17015

United States

Christiana Care Health System-Concord Health Center

Chadds Ford, Pennsylvania, 19317

United States

Chambersburg Hospital

Chambersburg, Pennsylvania, 17201

United States

Geisinger Medical Center

Danville, Pennsylvania, 17822

United States

Delaware County Memorial Hospital

Drexel Hill, Pennsylvania, 19026

United States

Northeast Radiation Oncology Center

Dunmore, Pennsylvania, 18512

United States

Saint Luke's Hospital-Anderson Campus

Easton, Pennsylvania, 18045

United States

Ephrata Cancer Center

Ephrata, Pennsylvania, 17522

United States

UPMC Hillman Cancer Center Erie

Erie, Pennsylvania, 16505

United States

Saint Vincent Hospital

Erie, Pennsylvania, 16544

United States

UPMC Cancer Center at UPMC Horizon

Farrell, Pennsylvania, 16121

United States

Adams Cancer Center

Gettysburg, Pennsylvania, 17325

United States

Crozer Regional Cancer Center at Brinton Lake

Glen Mills, Pennsylvania, 19342

United States

UPMC Cancer Centers - Arnold Palmer Pavilion

Greensburg, Pennsylvania, 15601

United States

UPMC Pinnacle Cancer Center/Community Osteopathic Campus

Harrisburg, Pennsylvania, 17109

United States

Penn State Milton S Hershey Medical Center

Hershey, Pennsylvania, 17033-0850

United States

IRMC Cancer Center

Indiana, Pennsylvania, 15701

United States

Jefferson Hospital

Jefferson Hills, Pennsylvania, 15025

United States

UPMC-Johnstown/John P. Murtha Regional Cancer Center

Johnstown, Pennsylvania, 15901

United States

Sechler Family Cancer Center

Lebanon, Pennsylvania, 17042

United States

Geisinger Medical Oncology-Lewisburg

Lewisburg, Pennsylvania, 17837

United States

Yolanda G Barco Oncology Institute

Meadville, Pennsylvania, 16335

United States

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion

Mechanicsburg, Pennsylvania, 17050

United States

Forbes Hospital

Monroeville, Pennsylvania, 15146

United States

UPMC Cancer Center - Monroeville

Monroeville, Pennsylvania, 15146

United States

UPMC Hillman Cancer Center - Monroeville

Monroeville, Pennsylvania, 15146

United States

UPMC Hillman Cancer Center in Coraopolis

Moon, Pennsylvania, 15108

United States

Allegheny Valley Hospital

Natrona Heights, Pennsylvania, 15065

United States

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107

United States

Jefferson Torresdale Hospital

Philadelphia, Pennsylvania, 19114

United States

Allegheny General Hospital

Pittsburgh, Pennsylvania, 15212

United States

UPMC-Saint Margaret

Pittsburgh, Pennsylvania, 15215

United States

West Penn Hospital

Pittsburgh, Pennsylvania, 15224

United States

University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, Pennsylvania, 15232

United States

UPMC-Shadyside Hospital

Pittsburgh, Pennsylvania, 15232

United States

UPMC-Passavant Hospital

Pittsburgh, Pennsylvania, 15237

United States

UPMC-Saint Clair Hospital Cancer Center

Pittsburgh, Pennsylvania, 15243

United States

Geisinger Cancer Services-Pottsville

Pottsville, Pennsylvania, 17901

United States

Saint Luke's Hospital - Upper Bucks Campus

Quakertown, Pennsylvania, 18951

United States

Saint Luke's Hospital-Quakertown Campus

Quakertown, Pennsylvania, 18951

United States

UPMC Cancer Center at UPMC Northwest

Seneca, Pennsylvania, 16346

United States

Saint Luke's Hospital - Monroe Campus

Stroudsburg, Pennsylvania, 18360

United States

Chester County Hospital

West Chester, Pennsylvania, 19380

United States

Reading Hospital

West Reading, Pennsylvania, 19611

United States

Wexford Health and Wellness Pavilion

Wexford, Pennsylvania, 15090

United States

Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre, Pennsylvania, 18711

United States

Divine Providence Hospital

Williamsport, Pennsylvania, 17754

United States

Asplundh Cancer Pavilion

Willow Grove, Pennsylvania, 19090

United States

WellSpan Health-York Cancer Center

York, Pennsylvania, 17403

United States

UPMC Memorial

York, Pennsylvania, 17408

United States

Saint Joseph's/Candler - Bluffton Campus

Bluffton, South Carolina, 29910

United States

Medical University of South Carolina

Charleston, South Carolina, 29425

United States

MUSC Health Florence Medical Center

Florence, South Carolina, 29505

United States

Saint Francis Hospital

Greenville, South Carolina, 29601

United States

Saint Francis Cancer Center

Greenville, South Carolina, 29607

United States

Self Regional Healthcare

Greenwood, South Carolina, 29646

United States

Gibbs Cancer Center-Pelham

Greer, South Carolina, 29651

United States

The Radiation Oncology Center-Hilton Head/Bluffton

Hilton Head Island, South Carolina, 29926

United States

Carolina Regional Cancer Center

Myrtle Beach, South Carolina, 29577

United States

Beaufort Memorial/New River Cancer Center

Okatie, South Carolina, 29909

United States

Spartanburg Medical Center

Spartanburg, South Carolina, 29303

United States

Sanford Cancer Center Oncology Clinic

Sioux Falls, South Dakota, 57104

United States

Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134

United States

The Children's Hospital at TriStar Centennial

Nashville, Tennessee, 37203

United States

Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232

United States

MD Anderson in The Woodlands

Conroe, Texas, 77384

United States

UT Southwestern Simmons Cancer Center - RedBird

Dallas, Texas, 75237

United States

UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390

United States

Brooke Army Medical Center

Fort Sam Houston, Texas, 78234

United States

UT Southwestern/Simmons Cancer Center-Fort Worth

Fort Worth, Texas, 76104

United States

M D Anderson Cancer Center

Houston, Texas, 77030

United States

MD Anderson West Houston

Houston, Texas, 77079

United States

MD Anderson League City

League City, Texas, 77573

United States

UT Southwestern Clinical Center at Richardson/Plano

Richardson, Texas, 75080

United States

University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229

United States

MD Anderson in Sugar Land

Sugar Land, Texas, 77478

United States

American Fork Hospital / Huntsman Intermountain Cancer Center

American Fork, Utah, 84003

United States

Sandra L Maxwell Cancer Center

Cedar City, Utah, 84720

United States

Farmington Health Center

Farmington, Utah, 84025

United States

Logan Regional Hospital

Logan, Utah, 84321

United States

Intermountain Medical Center

Murray, Utah, 84107

United States

McKay-Dee Hospital Center

Ogden, Utah, 84403

United States

Utah Valley Regional Medical Center

Provo, Utah, 84604

United States

Riverton Hospital

Riverton, Utah, 84065

United States

Saint George Regional Medical Center

Saint George, Utah, 84770

United States

University of Utah Sugarhouse Health Center

Salt Lake City, Utah, 84106

United States

Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112

United States

LDS Hospital

Salt Lake City, Utah, 84143

United States

Central Vermont Medical Center/National Life Cancer Treatment

Berlin, Vermont, 05602

United States

University of Vermont Medical Center

Burlington, Vermont, 05401

United States

Dartmouth Cancer Center - North

Saint Johnsbury, Vermont, 05819

United States

University of Virginia Cancer Center

Charlottesville, Virginia, 22908

United States

Inova Schar Cancer Institute

Fairfax, Virginia, 22031

United States

Inova Fair Oaks Hospital

Fairfax, Virginia, 22033

United States

Bon Secours Saint Francis Medical Center

Midlothian, Virginia, 23114

United States

Bon Secours Cancer Institute at Reynolds Crossing

Richmond, Virginia, 23230

United States

Virginia Commonwealth University/Massey Cancer Center

Richmond, Virginia, 23298

United States

Virginia Mason Medical Center

Seattle, Washington, 98101

United States

Legacy Cancer Institute Medical Oncology and Day Treatment

Vancouver, Washington, 98684

United States

Legacy Salmon Creek Hospital

Vancouver, Washington, 98686

United States

Providence Saint Mary Regional Cancer Center

Walla Walla, Washington, 99362

United States

Langlade Hospital and Cancer Center

Antigo, Wisconsin, 54409

United States

ThedaCare Regional Cancer Center

Appleton, Wisconsin, 54911

United States

Ascension Saint Elizabeth Hospital

Appleton, Wisconsin, 54915

United States

Northwest Wisconsin Cancer Center

Ashland, Wisconsin, 54806

United States

Ascension Southeast Wisconsin Hospital - Elmbrook Campus

Brookfield, Wisconsin, 53045

United States

Aurora Cancer Care-Southern Lakes VLCC

Burlington, Wisconsin, 53105

United States

Ascension Calumet Hospital

Chilton, Wisconsin, 53014

United States

Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, 54701

United States

Ascension Saint Francis - Reiman Cancer Center

Franklin, Wisconsin, 53132

United States

Aurora Health Care Germantown Health Center

Germantown, Wisconsin, 53022

United States

Aurora Cancer Care-Grafton

Grafton, Wisconsin, 53024

United States

Bellin Memorial Hospital

Green Bay, Wisconsin, 54301

United States

Saint Vincent Hospital Cancer Center Green Bay

Green Bay, Wisconsin, 54301

United States

Saint Vincent Hospital Cancer Center at Saint Mary's

Green Bay, Wisconsin, 54303

United States

Aurora BayCare Medical Center

Green Bay, Wisconsin, 54311

United States

University of Wisconsin Carbone Cancer Center - Johnson Creek

Johnson Creek, Wisconsin, 53038

United States

Aurora Cancer Care-Kenosha South

Kenosha, Wisconsin, 53142

United States

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center

Madison, Wisconsin, 53718

United States

University of Wisconsin Carbone Cancer Center - University Hospital

Madison, Wisconsin, 53792

United States

Aurora Bay Area Medical Group-Marinette

Marinette, Wisconsin, 54143

United States

Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449

United States

Froedtert Menomonee Falls Hospital

Menomonee Falls, Wisconsin, 53051

United States

Ascension Columbia Saint Mary's Hospital Ozaukee

Mequon, Wisconsin, 53097

United States

Aurora Cancer Care-Milwaukee

Milwaukee, Wisconsin, 53209

United States

Ascension Columbia Saint Mary's Hospital - Milwaukee

Milwaukee, Wisconsin, 53211

United States

Aurora Saint Luke's Medical Center

Milwaukee, Wisconsin, 53215

United States

Medical College of Wisconsin

Milwaukee, Wisconsin, 53226

United States

Aurora Sinai Medical Center

Milwaukee, Wisconsin, 53233

United States

Zablocki Veterans Administration Medical Center

Milwaukee, Wisconsin, 53295

United States

Marshfield Medical Center - Minocqua

Minocqua, Wisconsin, 54548

United States

ProHealth D N Greenwald Center

Mukwonago, Wisconsin, 53149

United States

Drexel Town Square Health Center

Oak Creek, Wisconsin, 53154

United States

ProHealth Oconomowoc Memorial Hospital

Oconomowoc, Wisconsin, 53066

United States

Ascension Mercy Hospital

Oshkosh, Wisconsin, 54904

United States

Vince Lombardi Cancer Clinic - Oshkosh

Oshkosh, Wisconsin, 54904

United States

Ascension All Saints Hospital

Racine, Wisconsin, 53405

United States

Aurora Cancer Care-Racine

Racine, Wisconsin, 53406

United States

Aspirus Cancer Care - James Beck Cancer Center

Rhinelander, Wisconsin, 54501

United States

Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868

United States

Saint Vincent Hospital Cancer Center at Sheboygan

Sheboygan, Wisconsin, 53081

United States

Vince Lombardi Cancer Clinic-Sheboygan

Sheboygan, Wisconsin, 53081

United States

Aspirus Cancer Care - Stevens Point

Stevens Point, Wisconsin, 54481

United States

Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, 54482

United States

Saint Vincent Hospital Cancer Center at Sturgeon Bay

Sturgeon Bay, Wisconsin, 54235-1495

United States

Aurora Medical Center in Summit

Summit, Wisconsin, 53066

United States

Vince Lombardi Cancer Clinic-Two Rivers

Two Rivers, Wisconsin, 54241

United States

UW Cancer Center at ProHealth Care

Waukesha, Wisconsin, 53188

United States

Aspirus Regional Cancer Center

Wausau, Wisconsin, 54401

United States

Ascension Medical Group Southeast Wisconsin - Mayfair Road

Wauwatosa, Wisconsin, 53226

United States

Aurora Cancer Care-Milwaukee West

Wauwatosa, Wisconsin, 53226

United States

Aurora West Allis Medical Center

West Allis, Wisconsin, 53227

United States

Froedtert West Bend Hospital/Kraemer Cancer Center

West Bend, Wisconsin, 53095

United States

Marshfield Medical Center - Weston

Weston, Wisconsin, 54476

United States

Aspirus Cancer Care - Wisconsin Rapids

Wisconsin Rapids, Wisconsin, 54494

United States

Collaborators and Investigators

Sponsor: NRG Oncology

Neil B Desai, PRINCIPAL_INVESTIGATOR, NRG Oncology

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-12-06

Study Completion Date2026-11-11

Study Record Updates

Study Start Date2021-12-06

Study Completion Date2026-11-11

Terms related to this study

Additional Relevant MeSH Terms

Prostate Adenocarcinoma