Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
Eligibility Criteria
- 1. Adolescents and adults with previously documented diagnosis of Glut1 Deficiency with diagnosis genetically confirmed or confirmed by PET scan of the brain.
- 2. Ages 16 to 65
- 3. Persons with dental fillings, dental crowns, and short (max.4 cm) dental retainer wires can be included.
- 1. People or patients with uncontrolled seizure disorder, defined as grand mal (not absence) seizure in the preceding 3 months.
- 2. Pregnant females will be excluded. A serum or urine pregnancy test will be administered to all females of child bearing potential within 24 hours of administration of the tracer and MRI scan. The pregnancy test will be communicated in person by the study PI. Positive results in subjects 17 years old or younger will be disclosed to parent/guardian only.
- 3. Subjects with typical implanted orthopedic metal in bone may be considered for inclusion in a 7T scan providing the implant is not within the volume of the radio frequency coil. The PI and the AIRC Medical Director will discuss each case and determine eligibility.
- 4. Persons with ICD, pacemakers, neurostimulators and other such devices will be excluded.
- 5. Persons with claustrophobia are excluded.
- 6. Persons with questionable ferrous implants, bullets, BB's, and shrapnel will be excluded.
- 7. Subjects who are not fluent in English will be excluded because immediate cooperation and the ability to respond to instructions from the investigators are necessary.
Ages Eligible for Study
16 Years to 65 Years
Sexes Eligible for Study
ALL
Accepts Healthy Volunteers
Yes