RECRUITING

Longitudinal Oral Microbiome Sampling for BE

Description

This is a longitudinal cohort study to assess the impact of repeated sampling of an oral microbiome signature for Barrett's esophagus (BE). Potential participants will be identified through chart review of patients who have had an endoscopy in the past three years.

Conditions

Barrett Esophagus
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Related Conditions:

Barrett Esophagus

Study Overview

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Study Details

Study overview

This is a longitudinal cohort study to assess the impact of repeated sampling of an oral microbiome signature for Barrett's esophagus (BE). Potential participants will be identified through chart review of patients who have had an endoscopy in the past three years.

Repeated Sampling of the Oral Microbiome to Improve Detection of Barrett's Esophagus

Longitudinal Oral Microbiome Sampling for BE

Condition
Barrett Esophagus
Intervention / Treatment

-

Contacts and Locations

Ann Arbor

University of Michigan, Ann Arbor, Michigan, United States, 48109

New York

Columbia University Irving Medical Center, New York, New York, United States, 10032

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Scheduled for an upper endoscopy or had upper endoscopy within past three years
  • * Eighteen years of age or older
  • * Capable of producing a saliva sample
  • * Able to give informed consent
  • * For BE patients only: Endoscopic evidence of Barrett's esophagus (at least 1 cm maximal BE length; i.e. Prague classification: any C, M≥1), and intestinal metaplasia present on esophageal biopsies
  • * History of head and neck cancer or esophageal squamous cell or gastric cancer
  • * History of esophageal or gastric surgery
  • * Scheduled to undergo colonoscopy on the day of initial saliva collection
  • * Scheduled only for Endoscopic retrograde cholangiopancreatography (ERCP) or Endoscopy ultrasound (EUS) without accompanying standard upper endoscopy on the day of initial saliva collection
  • * For BE patients only: History of prior endoscopic therapy for BE except a history of prior Endoscopic mucosal resection (EMR) of focal lesions without subsequent ablative therapy is permitted

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Columbia University,

Julian Abrams, MD, PRINCIPAL_INVESTIGATOR, Columbia University

Study Record Dates

2025-08