Staphylococcus Aureus Network Adaptive Platform Trial

Eligibility Criteria

• 1. Staphylococcus aureus complex grown from ≥1 blood culture
• 2. Admitted to a participating hospital at the time of eligibility assessment
• 1. Time of anticipated platform entry is greater than 72 hours post collection of the index blood culture. Where the time of culture collection is not recorded, the time of laboratory registration of the sample will be used as an alternative
• 2. Polymicrobial bacteraemia, defined as more than one organism (at species level) in the index blood cultures OR in any subsequent blood culture reported between the collection of the index blood culture and platform eligibility assessment, excluding those organisms judged to be contaminants by either the microbiology laboratory or treating clinician.
• 3. Known previous participation in the randomised SNAP platform
• 4. Known positive blood culture for S. aureus (of the same silo: PSSA, MSSA or MRSA) between 72 hours and 180 days prior to the time of eligibility assessment
• 5. Treating team deems enrolment in the study is not in the best interest of the patient
• 6. Treating team believes that death is imminent and inevitable
• 7. Patient is for end-of-life care and antibiotic treatment is considered not appropriate
• 8. Patient \<18 years of age and paediatric recruitment not approved at recruiting site
• 9. Patient has died since the collection of the index blood culture