RECRUITING

Genetic and Cognitive Predictors of Aphasia Treatment Response

Conditions

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Aphasia, or language impairment after a stroke, affects approximately 2 million people in the United States, with an estimated 180,000 new cases each year. The medical community cannot predict how well someone with aphasia will respond to treatment, as some people with aphasia are poor responders to intervention even when participating in empirically supported treatments. There is a strong likelihood that genetics play a role in language recovery after stroke, but very little research has been dedicated to investigating this link. This study will investigate whether two genes and cognitive abilities, such as memory, predict responsiveness to aphasia therapy for word-retrieval difficulties.

Official Title

Laying the Groundwork for Personalized Medicine in Aphasia Therapy: Genetic and Cognitive Predictors of Restorative Treatment Response

Quick Facts

Study Start:2020-10-23
Study Completion:2025-08
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05179538

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 85 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * At least six months post-onset of a single left-hemisphere stroke
  2. * Chronic aphasia
  3. * Anomia (word-retrieval deficits)
  4. * Native English Speaker.
  1. * Severe motor speech disorders
  2. * Severe auditory comprehension deficits
  3. * Severe depression.
  4. * Diffuse injury or disease of the brain
  5. * Uncorrected vision or hearing difficulties
  6. * Contraindications for MRI (e.g. cardiac pacemaker, ferrous metal implants, claustrophobia, pregnancy).

Contacts and Locations

Study Contact

Stacy Harnish, PhD, CCC-SLP
CONTACT
6146881471
aphasialab@osu.edu
Grace Terry, MA, CFY-SLP
CONTACT
terry.310@buckeyemail.osu.edu

Principal Investigator

Stacy M Harnish, PhD
PRINCIPAL_INVESTIGATOR
Ohio State University

Study Locations (Sites)

The Ohio State University
Columbus, Ohio, 43210
United States

Collaborators and Investigators

Sponsor: Ohio State University

  • Stacy M Harnish, PhD, PRINCIPAL_INVESTIGATOR, Ohio State University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-10-23
Study Completion Date2025-08

Study Record Updates

Study Start Date2020-10-23
Study Completion Date2025-08

Terms related to this study

Additional Relevant MeSH Terms

  • Aphasia