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MS-ResearchBiomarkerS

Description

This study is being conducted to investigate risk factors for disability progression in Multiple Sclerosis and related disorders (MSRD). The primary goal is to assess whether combining information from visual assessment, blood markers, as well as historical and ongoing longitudinal MRIs of the brain, orbit (the part of the skull where eyes are located), and/or spinal cord can predict changes in quantitative disability measures related to MSRD and neurological disease.

Conditions

Multiple SclerosisMultiple Sclerosis, Relapsing-RemittingMultiple Sclerosis, Primary ProgressiveMultiple Sclerosis, Secondary ProgressiveClinically Isolated SyndromeRadiologically Isolated SyndromeNeuromyelitis Optica Spectrum DisordersMyelin Oligodendrocyte Glycoprotein Antibody-associated DiseaseNeurologic Autoimmune DiseaseNeurologic DisorderHealthy Aging
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Related Conditions:

Multiple SclerosisMultiple Sclerosis, Relapsing-RemittingMultiple Sclerosis, Primary ProgressiveMultiple Sclerosis, Secondary ProgressiveClinically Isolated SyndromeRadiologically Isolated SyndromeNeuromyelitis Optica Spectrum DisordersMyelin Oligodendrocyte Glycoprotein Antibody-associated DiseaseNeurologic Autoimmune DiseaseNeurologic DisorderHealthy Aging

Study Overview

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Study Details

Study overview

This study is being conducted to investigate risk factors for disability progression in Multiple Sclerosis and related disorders (MSRD). The primary goal is to assess whether combining information from visual assessment, blood markers, as well as historical and ongoing longitudinal MRIs of the brain, orbit (the part of the skull where eyes are located), and/or spinal cord can predict changes in quantitative disability measures related to MSRD and neurological disease.

Investigating the Longitudinal Relationships Between Visual Pathway Injury, Radiological and Blood Biomarkers in Multiple Sclerosis and Related Disorders

MS-ResearchBiomarkerS

Condition
Multiple Sclerosis
Intervention / Treatment

-

Contacts and Locations

Los Angeles

Cedars-Sinai Medical Center, Los Angeles, California, United States, 90048

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Subjects who meet any one of the following diagnostic criteria:
  • * Diagnosis of MS, CIS,or RIS based on the 2017 revised McDonald criteria.
  • * Diagnosis of NMOSD based on the 2015 revised NMOSD consensus diagnostic criteria.
  • * Diagnosis of myelin oligodendrocyte glycoprotein (MOG)-related encephalomyelitis, optic neuritis, or other associated disease.
  • * Diagnosis of neurological disorders other than MSRD.
  • * Healthy volunteer.
  • * Age ≥18.
  • * Able to give informed consent.
  • * Patients will be excluded from the MRI portions of the study if they have a contraindication to MRI(metallic implantsor foreign bodies, claustrophobia, MRI-incompatible pacemakers, MRI- incompatible prosthetic heart valves).
  • * Patients will be excluded from the MRI portions of the study if they are pregnant, but their demographic, clinical information,and disability measures may still be captured under the study.
  • * Patients will be excluded from the visual assessment portions of the study if they have had any recent ocular surgery (within the past two months), refractive errors of greater than or equal to ±6 diopters or other eye diseases that may affect or confound OCT/OCTA measurements (ex., age-related macular degeneration, advanced geographic atrophy, diabetic retinopathy, glaucoma).

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Cedars-Sinai Medical Center,

Omar Al-Louzi, MD, PRINCIPAL_INVESTIGATOR, Cedars-Sinai Medical Center

Marwa Kaisey, MD, STUDY_DIRECTOR, Cedars-Sinai Medical Center

Brooke Guerrero, MD, STUDY_DIRECTOR, Cedars-Sinai Medical Center

Laura Locke, CRNP, STUDY_DIRECTOR, Cedars-Sinai Medical Center

Pascal Sati, PhD, STUDY_DIRECTOR, Cedars-Sinai Medical Center

Nancy Sicotte, MD, STUDY_CHAIR, Cedars-Sinai Medical Center

Study Record Dates

2041-11-11