Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076)

Eligibility Criteria

• * Histologically confirmed (from prior treatment) non-resectable ovarian, fallopian tube or primary peritoneal cancer.
• * High-grade serous \[including malignant mixed Mullerian tumor (MMMT) with metastasis that contains high-grade epithelial carcinoma, FIGO grades 2 \& 3 allowed\], endometrioid, or clear-cell ovarian cancer.
• * Performance status ECOG of 0 or 1.
• * Life expectancy of at least 6 months.
• * Received a minimum of 3 prior lines (including the 1st line) of systemic therapy with no maximal limit.
• * Time from Last Platinum of less than or equal to 24 months since the last dose of platinum in the most recent platinum-based line of therapy (excluding using platinum as a radiosensitizer) until consent into this trial.
• * Platinum-resistant or -refractory disease based on platinum-free interval (PFI) from the last dose of the most recent. platinum-based line of therapy (must have received a minimum of 2 doses of platinum in that line) to subsequent disease progression based on radiological assessment. Platinum-refractory: PFI of \< 1 month (including disease progression while on platinum-based therapy). Platinum-resistant: PFI of 1-6 months.
• * Received prior bevacizumab (or biosimilar) treatment.
• * No contraindication to receive carboplatin, cisplatin or bevacizumab (or biosimilar).
• * Have disease progression after last prior line of therapy based on radiological assessment prior to randomization.
• * At least 1 measurable target lesion per RECIST 1.1 based on abdominal/pelvis imaging scan at screening.
• * Evidence by CT and/or PET scans or physical exam of abdominal/pelvis region likely having disease in the peritoneal cavity (i.e., peritoneal carcinomatosis).
• * Adequate renal, hepatic, bone marrow function, adequate coagulation tests, adequate immune function by lymphocyte count.
• * Tumors of mucinous, low-grade serous, squamous cell, small cell neuroendocrine subtypes, MMMT tumors absent an epithelial component on recent biopsy, or non-epithelial ovarian cancers (e.g., germ cell tumors, Sex-cord tumors).
• * Bowel obstruction within last 3 months prior to screening.
• * Active urinary tract infection, pneumonia, other systemic infections.
• * Active gastrointestinal bleeding.
• * Known current central nervous system (CNS) metastasis.
• * Inflammatory diseases of the bowel.
• * History of HIV infection.
• * Active hepatitis B virus or hepatitis C virus within 4 weeks prior to study.
• * History of thromboembolic event within the prior 3 months.
• * Contraindications for intraperitoneal (IP) catheter placement: Bowel obstruction with distended abdomen, rigid abdomen with bulky anterior wall carcinomatosis, abdominal wall hernia mesh that precludes laparoscopic entry to abdomen.
• * Clinically significant cardiac disease at screening (New York Heart Association Class III/IV).
• * Acute cerebrovascular event(s) such as cerebrovascular accident (CVA) or transient ischemic attack (TIA) in previous 6 months.
• * Oxygen saturation \<90%.
• * Received prior virus-based gene therapy or therapy with cytolytic virus of any type.
• * Receiving concurrent antiviral agent.
• * Prior malignancy of other histology active within previous 3 years except for locally curable cancers apparently cured such as basal/squamous cell skin cancer, superficial bladder cancer, carcinoma in situ of cervix or breast, any other stage I/II local malignancies.
• * Received chemotherapy, radiotherapy, other anti-cancer biologic therapies within 4 weeks prior to planned treatment.
• * Underwent surgery within 4 weeks, or have insufficient recovery from surgical-related trauma or wound healing, prior to first study treatment in either Arm.
• * Receiving immunosuppressive therapy or steroids (except acute concurrent corticosteroid of no more than 20 mg per day for medical management with prednisolone equivalent.
• * Symptomatic malignant ascites or pleural effusions defined as rapidly progressive ascites with abdominal distension and gastrointestinal dysfunction, pleural effusions with respiratory difficulties requiring frequent paracentesis \> once every 14 days.
• * Known hypersensitivity to gentamicin.