Cardiac Outcomes With Near-Complete Estrogen Deprivation

Eligibility Criteria

• * History of allergic reactions attributed to compounds of similar chemical or biologic composition to adenosine
• * Active wheezing.
• * Those with contraindications for MRI such as ferromagnetic cerebral aneurysm clips or other intracranial metal, pacemakers, defibrillators, functioning neurostimulator devices or other implanted electronic devices, or some breast expanders.
• * Uncontrolled intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
• * Pregnant women are excluded from this study. Because some methods of birth control are not 100% reliable, a pregnancy test is required, unless the patient has undergone either a bilateral oophorectomy, hysterectomy or both.
• * Coronary revascularization in the past 6 months or known severe multi-vessel coronary artery disease previously determined to be not amendable to mechanical intervention.
• * Ongoing, unrelieved symptoms thought to represent cardiac ischemia and requiring immediate cardiac catheterization
• * Allergy or prior sensitivity to gadolinium or other contrasting agents or their excipients.
• * Men with breast cancer.
• * Known chronic renal insufficiency or chronic electrolyte abnormalities as determined by the treating physician.