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Personalized Risk Estimation for Crohn's Disease (PRE-Crohn's): Implementation and Feasibility

Description

The aim of this study is to develop and assess the feasibility and effect of a web-based, personalized risk-estimation for Crohn's disease (PRE-Crohn's) tool on behaviors and biomarkers associated with risk for Crohn's disease in unaffected first-degree relatives of patients with inflammatory bowel disease. We hypothesize that personalized risk disclosure via the PRE-Crohn's educational tool is both feasible and successful in modifying behaviors associated with Crohn's disease risk and normalizing pre-clinical disease biomarkers when compared to standard Crohn's disease education. Broadly, completion of this project will also help elucidate the role of lifestyle and dietary factors in pre-clinical Crohn's disease development in high-risk individuals, and provide novel insight into potential strategies for disease prevention in this population.

Conditions

Inflammatory Bowel DiseasesCrohn DiseaseCrohn ColitisCrohn's IleocolitisCrohn's GastritisCrohn's JejunitisCrohn's DuodenitisCrohn's Esophagitis
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Related Conditions:

Inflammatory Bowel DiseasesCrohn DiseaseCrohn ColitisCrohn's IleocolitisCrohn's GastritisCrohn's JejunitisCrohn's DuodenitisCrohn's Esophagitis

Study Overview

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Study Details

Study overview

The aim of this study is to develop and assess the feasibility and effect of a web-based, personalized risk-estimation for Crohn's disease (PRE-Crohn's) tool on behaviors and biomarkers associated with risk for Crohn's disease in unaffected first-degree relatives of patients with inflammatory bowel disease. We hypothesize that personalized risk disclosure via the PRE-Crohn's educational tool is both feasible and successful in modifying behaviors associated with Crohn's disease risk and normalizing pre-clinical disease biomarkers when compared to standard Crohn's disease education. Broadly, completion of this project will also help elucidate the role of lifestyle and dietary factors in pre-clinical Crohn's disease development in high-risk individuals, and provide novel insight into potential strategies for disease prevention in this population.

Personalized Risk Estimation for Crohn's Disease (PRE-Crohn's): Implementation and Feasibility

Personalized Risk Estimation for Crohn's Disease (PRE-Crohn's): Implementation and Feasibility

Condition
Inflammatory Bowel Diseases
Intervention / Treatment

-

Contacts and Locations

Boston

Massachusetts General Hospital, Boston, Massachusetts, United States, 02114

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Ability to give informed consent
  • * Ability and willingness to comply with all patient visits and study-related procedures
  • * Ability to understand and complete study questionnaires
  • * Must have at least one first-degree relative with inflammatory bowel disease (Crohn's disease, ulcerative colitis, or indeterminate colitis/IBD unclassified)
  • * Individuals greater than 14 years of age
  • * Inability to provide informed consent
  • * Inability to comply with all patient visits and study-related procedures
  • * Inability to understand or complete study questionnaires
  • * Patients with existing diagnoses of inflammatory bowel disease (ulcerative colitis, Crohn's disease, or indeterminate colitis/IBD unclassified)
  • * Evidence of clinical signs or symptoms of inflammatory bowel disease, identified by a modified version of the Harvey-Bradshaw Index for CD activity

Ages Eligible for Study

14 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Massachusetts General Hospital,

Emily Lopes, MD, PRINCIPAL_INVESTIGATOR, Massachusetts General Hospital

Study Record Dates

2026-11