RECRUITING

Dronabinol After Arthroscopic Surgery

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of the proposed study is to evaluate the efficacy of dronabinol for postoperative pain after arthroscopic surgery of the knee. The investigators hypothesize that dronabinol will relieve pain, reduce opioid consumption and will result in few negative side effects. If this pilot study shows promising results the investigators will expand the trial to include additional arthroscopic surgeries (hip, shoulder) and other types of orthopaedic surgery.

Official Title

Dronabinol for the Treatment of Postoperative Pain After Arthroscopic Surgery: a Pilot Randomized Trial

Quick Facts

Study Start:2022-06-28
Study Completion:2025-06
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05335252

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age 18 years or older
  2. * Patient who will undergo arthroscopic surgery of the knee including, but not limited to,
  3. * Meniscectomy
  4. * Synovectomy
  5. * Chondroplasty
  6. * Loose body removal
  1. * Patients under age 18 years
  2. * Patients who cannot provide consent
  3. * Patients who are pregnant, breast feeding, or are trying to become pregnant during the study period
  4. * Patients with an allergy to any of the study drugs
  5. * Patient who are lactose-intolerant
  6. * Revision surgery
  7. * Open surgery
  8. * Comorbidities preventing surgery
  9. * Patients with a history of mania, depression, or schizophrenia
  10. * Patients taking any of the following drugs or supplements
  11. * Anticholinergic agents
  12. * Benzodiazepines
  13. * Central nervous system depressants
  14. * Droperidol
  15. * Hydroxyzine
  16. * Levomepromazine or methotrimeprazine
  17. * Monoamine oxidase inhibitors
  18. * Ritonavir
  19. * Selective serotonin reuptake inhibitors
  20. * Sympathomimetics
  21. * St. John's Wort
  22. * Current diagnosed alcohol or drug abuse
  23. * Patients who cannot or will not abide by the medication restrictions listed below
  24. * Participants must agree to abstain from using recreational or medical marijuana products or cannabidiol (CBD) in any form during the treatment period
  25. * Participants should not drink alcohol or take other drugs while taking the study drug or hydrocodone/acetaminophen

Contacts and Locations

Study Contact

Melissa J Shauver, MPH
CONTACT
312-472-6024
melissa.shauver1@nm.org
Abbie P Bennett, MS
CONTACT
312-922-6024
abbie.bennett@nm.org

Principal Investigator

Vehniah K Tjong, MD
PRINCIPAL_INVESTIGATOR
Northwestern Feinberg School of Medicine

Study Locations (Sites)

Northwestern University Feinberg School of Medicine
Chicago, Illinois, 60611
United States

Collaborators and Investigators

Sponsor: Northwestern University

  • Vehniah K Tjong, MD, PRINCIPAL_INVESTIGATOR, Northwestern Feinberg School of Medicine

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-06-28
Study Completion Date2025-06

Study Record Updates

Study Start Date2022-06-28
Study Completion Date2025-06

Terms related to this study

Keywords Provided by Researchers

  • Knee Arthroscopy

Additional Relevant MeSH Terms

  • Knee Osteoarthritis
  • Knee Injuries
  • Meniscus Tear
  • Synovitis of Knee
  • Knee Ligament Injury
  • Chondral Injury of Left Knee
  • Chondral Injury of Right Knee
  • Loose Body Knee