RECRUITING

Microbiome Dysfunction in Surgical Intensive Care Unit Survivors

Description

Oral and gastrointestinal microbiome dysfunction has been demonstrated to be a culprit of various systemic dysfunctions in peripheries such as cardiovascular, nervous, endocrine and musculoskeletal systems. The topic of microbiome dysfunction after surgical intensive care admission is understudied but may be responsible for persistent systemic inflammation clinically observed in surgical intensive care patients. Therefore, the objective of this project is to investigate the oral and gut microbiome after the acute phase of sepsis, severe trauma injury, cardiopulmonary bypass, and major vascular surgery to compare with 108 age-matched healthy population controls

Conditions

Sepsis, Trauma Injury
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Related Conditions:

Sepsis, Trauma Injury

Study Overview

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Study Details

Study overview

Oral and gastrointestinal microbiome dysfunction has been demonstrated to be a culprit of various systemic dysfunctions in peripheries such as cardiovascular, nervous, endocrine and musculoskeletal systems. The topic of microbiome dysfunction after surgical intensive care admission is understudied but may be responsible for persistent systemic inflammation clinically observed in surgical intensive care patients. Therefore, the objective of this project is to investigate the oral and gut microbiome after the acute phase of sepsis, severe trauma injury, cardiopulmonary bypass, and major vascular surgery to compare with 108 age-matched healthy population controls

Microbiome Dysfunction in Surgical Intensive Care Unit Survivors Subtitle: The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma Pathological Myeloid Activation After Sepsis and Trauma

Microbiome Dysfunction in Surgical Intensive Care Unit Survivors

Condition
Sepsis, Trauma Injury
Intervention / Treatment

-

Contacts and Locations

Gainesville

UF Health at Shands Hospital, Gainesville, Florida, United States, 32610

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Adult (\>18 years age) patients undergoing open cardiac surgery
  • 2. Ability to obtain patient informed consent
  • 3. was placed on cardiopulmonary bypass at their initial operation at UF Health
  • 1. Inability to obtain informed consent,
  • 2. Pregnancy
  • 3. Evidence of multi-organ failure on presentation
  • 4. Patients with any pre-existing hematological disease (e.g. hemochromatosis, myelodysplastic syndrome, hematologic cancers
  • 5. Prisoners
  • 6. Previous bone marrow transplantation
  • 7. Burn injury greater than 20% TBSA

Ages Eligible for Study

18 Years to 110 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Florida,

Philip Efron, MD, PRINCIPAL_INVESTIGATOR, UF COM Department of Surgery

Study Record Dates

2028-05-31