RECRUITING

Causal Role of Brain Networks in Episodic Memory

Conditions

Episodic Memory Healthy cognitive neuroscience functional magnetic resonance imaging transcranial magnetic stimulation

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this study is to understand the basic brain mechanisms supporting episodic memory in healthy young adults. Transcranial magnetic stimulation will be used to influence brain activity in regions thought to be important for episodic memory. Behavioral testing and MRI will be used to measure the effects of stimulation on memory and on changes in brain network interactions, allowing us to draw causal inferences regarding the role of specific brain regions in memory processes.

Official Title

Causal Role of Brain Networks in Episodic Memory

Quick Facts

Study Start:2023-10-06

Study Completion:2024-12-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT05374551

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 35 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT

Inclusion Criteria	Exclusion Criteria
* Ages 18 to 35 years old * Fluent in English * Free of major neurological or psychiatric illness * Right-handed * Normal or corrected to normal vision	* History of a psychiatric illness within the past two years * History of a learning disorder (e.g., attention deficit disorder, dyslexia) * History of neurological disorder or brain injury, including family history of epilepsy, convulsions or seizures, stroke; vascular, traumatic, tumoral, infectious, or metabolic lesion of the brain, even without a history of seizure, and without anticonvulsant medication, and any unexplained lifetime loss of consciousness/syncope * Use of medications that reduce seizure threshold (e.g., tricyclic antidepressants, neuroleptic agents) * History of neurosurgery * History of heart disease * Recreational drug use in the past two months * Uncontrollable shaking, or inability to sit/lie still for one hour * Evidence of neurological disorders or structural abnormalities, based on MRI * Pregnancy * Prior surgeries, conditions, and/or implants that are not MRI-safe, including: pacemaker, pacemaker wires, artificial heart valve, brain aneurysm surgery, middle ear implant, non-removable hearing aids, braces, or extensive dental work, implanted mechanical or electrical device, artificial limb or joint * Foreign metallic objects in the body, such as bullets, BBs, shrapnel, or metalwork fragments * History of metal work or ocular metallic foreign bodies * History of uncontrolled migraines or susceptibility to headaches * Use of centrally-acting medications and drugs, with the exception of caffeine, within the last 12 hours * Concurrent treatment with ototoxic medications * Current sleep deprivation, extreme fatigue, or recent jet lag * Claustrophobia * Pre-existing noise induced hearing loss * Any prior adverse experience (e.g. physical or psychological discomfort) with repetitive TMS or MRI scanning

Inclusion Criteria

Exclusion Criteria

* Ages 18 to 35 years old
* Fluent in English
* Free of major neurological or psychiatric illness
* Right-handed
* Normal or corrected to normal vision

* History of a psychiatric illness within the past two years
* History of a learning disorder (e.g., attention deficit disorder, dyslexia)
* History of neurological disorder or brain injury, including family history of epilepsy, convulsions or seizures, stroke; vascular, traumatic, tumoral, infectious, or metabolic lesion of the brain, even without a history of seizure, and without anticonvulsant medication, and any unexplained lifetime loss of consciousness/syncope
* Use of medications that reduce seizure threshold (e.g., tricyclic antidepressants, neuroleptic agents)
* History of neurosurgery
* History of heart disease
* Recreational drug use in the past two months
* Uncontrollable shaking, or inability to sit/lie still for one hour
* Evidence of neurological disorders or structural abnormalities, based on MRI
* Pregnancy
* Prior surgeries, conditions, and/or implants that are not MRI-safe, including: pacemaker, pacemaker wires, artificial heart valve, brain aneurysm surgery, middle ear implant, non-removable hearing aids, braces, or extensive dental work, implanted mechanical or electrical device, artificial limb or joint
* Foreign metallic objects in the body, such as bullets, BBs, shrapnel, or metalwork fragments
* History of metal work or ocular metallic foreign bodies
* History of uncontrolled migraines or susceptibility to headaches
* Use of centrally-acting medications and drugs, with the exception of caffeine, within the last 12 hours
* Concurrent treatment with ototoxic medications
* Current sleep deprivation, extreme fatigue, or recent jet lag
* Claustrophobia
* Pre-existing noise induced hearing loss
* Any prior adverse experience (e.g. physical or psychological discomfort) with repetitive TMS or MRI scanning

Contacts and Locations

Study Contact

Maureen Ritchey, PhD

CONTACT

617-552-4779

maureen.ritchey@bc.edu

Study Locations (Sites)

Boston College

Chestnut Hill, Massachusetts, 02467

United States

Collaborators and Investigators

Sponsor: Boston College

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-10-06

Study Completion Date2024-12-31

Study Record Updates

Study Start Date2023-10-06

Study Completion Date2024-12-31

Terms related to this study

Keywords Provided by Researchers

cognitive neuroscience
functional magnetic resonance imaging
transcranial magnetic stimulation

Additional Relevant MeSH Terms

Episodic Memory
Healthy