ACTIVE_NOT_RECRUITING

Neurofeedback for Borderline Personality Disorder

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Conditions

Borderline Personality DisorderfMRI neurofeedbackamygdala

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this study is to evaluate whether rtfMRI-nf training to increase the amygdala response to positive memories may serve as an intervention for borderline personality disorder.

Official Title

Amygdala rtfMRI Neurofeedback for Borderline Personality Disorder

Quick Facts

Study Start:2022-09-02
Study Completion:2025-10-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:ACTIVE_NOT_RECRUITING

Study ID

NCT05398627

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 55 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * right-handed adults (ages 18 - 55) with a primary diagnosis of Borderline Personality Disorder according to diagnostic criteria in the Structured Interview for DSM Personality Disorders
  2. * must be able to give written informed consent prior to participation
  3. * unmedicated or stable on an SSRI antidepressant regime (at least 3 weeks to ensure symptoms are stable)
  4. * English speaking
  1. * have a clinically significant or unstable cardiovascular, pulmonary, endocrine, neurological, gastrointestinal illness or unstable medical disorder
  2. * Current moderate or severe DSM-V alcohol or substance use disorder, with the exception of nicotine or caffeine. Clinician will access subjects' alcohol and substance use on a case-by-case to determine whether specific cases of mild alcohol or substance use would also interfere with the effects of the intervention.
  3. * have a history of traumatic brain injury
  4. * are unable to complete MRI scan due to claustrophobia or general MRI exclusions (e.g., shrapnel inside body)
  5. * are currently pregnant or breast feeding
  6. * are unable to complete questionnaires written in English
  7. * current (within 3 weeks of testing) use of any antipsychotics, benzodiazepines, beta-blockers, or other medications (except SSRI antidepressants) likely to influence cerebral blood flow. Effective medications will not be discontinued for the purposes of the study. Inclusion of patients on stable antidepressant medications was decided in order to allow generalization towards a real world population
  8. * have a DSM-5 diagnosis of psychotic or organic mental disorder
  9. * have any eye problems or difficulties in corrected vision.
  10. * Serious suidicial ideation

Contacts and Locations

Principal Investigator

Kymberl Young, PhD
PRINCIPAL_INVESTIGATOR
University of Pittsburgh

Study Locations (Sites)

University of Pittsburgh
Pittsburgh, Pennsylvania, 15213
United States

Collaborators and Investigators

Sponsor: Kymberly Young

  • Kymberl Young, PhD, PRINCIPAL_INVESTIGATOR, University of Pittsburgh

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-09-02
Study Completion Date2025-10-31

Study Record Updates

Study Start Date2022-09-02
Study Completion Date2025-10-31

Terms related to this study

Keywords Provided by Researchers

  • fMRI neurofeedback
  • amygdala

Additional Relevant MeSH Terms

  • Borderline Personality Disorder