RECRUITING

Deep Brain Stimulation for Visuomotor Function in Parkinson's Disease

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Inability to align and refocus the eyes on the objects at different depths, i.e., vergence impairment, frequently affects the quality of life in patients with Parkinson's disease. Our study aims to understand the location-specific effects of subthalamic region deep brain stimulation on vergence by integrating the patient-specific deep brain stimulation models and high-resolution eye-tracking measures. The knowledge gained will allow us to find the most beneficial stimulation location and parameters for improving binocular coordination and vergence while preserving the ability to treat motor symptoms in Parkinson's disease.

Official Title

Deep Brain Stimulation for Visuomotor Function in Parkinsons Disease

Quick Facts

Study Start:2022-10-04
Study Completion:2025-07-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05400499

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:Not specified
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Parkinson's disease with bilateral STN DBS
  2. * Availability of pre-operative MR images (with a T1-weighted, gradient-echo sequence) and ability to get post-operative MRI or CT scans
  3. * Hoehn and Yahr stage 2-4 when off medication, and a stable antiparkinsonian medication regimen and DBS parameter settings
  1. * Previous surgical therapy for Parkinson's disease (other than DBS)
  2. * Dementia
  3. * Clinically significant untreated depression or anxiety
  4. * Clinical features suggestive of atypical parkinsonism

Contacts and Locations

Study Contact

Aasef G Shaikh, MD PhD
CONTACT
(216) 791-3800
Aasef.Shaikh@va.gov
Monica O'Loughlin
CONTACT
(216) 791-3800
Monica.O'Loughlin@va.gov

Principal Investigator

Aasef G. Shaikh, MD PhD
PRINCIPAL_INVESTIGATOR
Louis Stokes VA Medical Center, Cleveland, OH

Study Locations (Sites)

Louis Stokes VA Medical Center, Cleveland, OH
Cleveland, Ohio, 44106-1702
United States

Collaborators and Investigators

Sponsor: VA Office of Research and Development

  • Aasef G. Shaikh, MD PhD, PRINCIPAL_INVESTIGATOR, Louis Stokes VA Medical Center, Cleveland, OH

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-10-04
Study Completion Date2025-07-01

Study Record Updates

Study Start Date2022-10-04
Study Completion Date2025-07-01

Terms related to this study

Keywords Provided by Researchers

  • Parkinson's disease
  • Deep brain stimulation
  • Subthalamic nucleus

Additional Relevant MeSH Terms

  • Parkinson's Disease