Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
Eligibility Criteria
- * Patients with primarily unresectable/ potentially resectable CRLM with a FLR \<30% (\<40% in chemotherapy damaged livers)
- * Patients with non-resected primary CRC may be included if there is an intention to resect the CRC after the liver treatment (liver first approach) or simultaneously during one of the liver procedures.
- * Patients with resectable or ablatable lung or brain metastases can be included (statement about the resectability of these extrahepatic metastases by a tumor board needs to be available)
- * 18 Years and older
- * Men and women
- * Able to understand the trial and provide informed consent.
- * Pregnant or lactating female.
- * Premenopausal females not able or willing to commit to oral contraception
- * Patients with prohibitive comorbidities, decision made by local team
- * Any patient with non-resectable or non-ablatable extrahepatic disease
- * Patients with hepatic malignancies other than CRLM
- * Progression of disease by RECIST criteria after cytoreduction chemotherapy
- * Complete response after conversion chemotherapy
- * Staging CT and (if indicated) CT/MRI brain that demonstrates non-resectable extrahepatic disease
- * The anatomy of the liver or manifestation of tumors in relation to the liver veins prohibits the use of combined PVE/HVE.
Ages Eligible for Study
18 Years to
Sexes Eligible for Study
ALL
Accepts Healthy Volunteers
No