RECRUITING

Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History

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Conditions

Mild Cognitive ImpairmentAmnestic Mild Cognitive DisorderAmnestic Mild Cognitive ImpairmentMild Traumatic Brain InjuryConcussion, BrainMCITBImemorybiomarkerAlzheimer

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study will probe if the biological changes in amnestic mild cognitive impairment (aMCI) are related to a history of mild traumatic brain injury (mTBI) using high definition transcranial direct current stimulation (HD-tDCS) and blood-derived biomarker tools. Participants who Do as well as those who Do Not have a history of mTBI will be enrolled in the study.

Official Title

Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History

Quick Facts

Study Start:2023-04-20
Study Completion:2027-05-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05446584

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:55 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Active diagnosis of amnestic mild cognitive impairment
  2. 2. Presence of an mTBI history for the mTBI+ group; absence of an mTBI history for a control sample
  3. 3. Female and male subjects
  4. 4. All races/ethnicities
  5. 5. Age 55 years and older
  6. 6. Fluent in English
  1. 1. Mild traumatic brain injury within past year
  2. 2. Lifetime history of moderate or severe brain injury
  3. 3. Lifetime major neurologic syndromes (e.g., stroke, epilepsy, brain tumor)
  4. 4. Lifetime major cardiovascular conditions (e.g., heart attack, heart failure)
  5. 5. Current substance use disorder
  6. 6. Current major psychiatric disorders (e.g., major depressive disorder, bipolar disorder)
  7. 7. Current vision or hearing impairment that interferes with testing
  8. 8. Any electronic and or metallic implants in the skull or brain
  9. 9. Current medication use known to alter HD-tDCS reactivity

Contacts and Locations

Study Contact

Hannah Cabrera, MCRC
CONTACT
214-865-9508
Hannah.Cabrera@utsw.edu

Study Locations (Sites)

University of Texas Southwestern Medical Center
Dallas, Texas, 75390
United States

Collaborators and Investigators

Sponsor: University of Texas Southwestern Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-04-20
Study Completion Date2027-05-31

Study Record Updates

Study Start Date2023-04-20
Study Completion Date2027-05-31

Terms related to this study

Keywords Provided by Researchers

  • MCI
  • TBI
  • memory
  • biomarker
  • Alzheimer

Additional Relevant MeSH Terms

  • Mild Cognitive Impairment
  • Amnestic Mild Cognitive Disorder
  • Amnestic Mild Cognitive Impairment
  • Mild Traumatic Brain Injury
  • Concussion, Brain