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Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History

Description

This study will probe if the biological changes in amnestic mild cognitive impairment (aMCI) are related to a history of mild traumatic brain injury (mTBI) using high definition transcranial direct current stimulation (HD-tDCS) and blood-derived biomarker tools. Participants who Do as well as those who Do Not have a history of mTBI will be enrolled in the study.

Conditions

Mild Cognitive ImpairmentAmnestic Mild Cognitive DisorderAmnestic Mild Cognitive ImpairmentMild Traumatic Brain InjuryConcussion, Brain
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Related Conditions:

Mild Cognitive ImpairmentAmnestic Mild Cognitive DisorderAmnestic Mild Cognitive ImpairmentMild Traumatic Brain InjuryConcussion, Brain

Study Overview

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Study Details

Study overview

This study will probe if the biological changes in amnestic mild cognitive impairment (aMCI) are related to a history of mild traumatic brain injury (mTBI) using high definition transcranial direct current stimulation (HD-tDCS) and blood-derived biomarker tools. Participants who Do as well as those who Do Not have a history of mTBI will be enrolled in the study.

Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History

Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History

Condition
Mild Cognitive Impairment
Intervention / Treatment

-

Contacts and Locations

Dallas

University of Texas Southwestern Medical Center, Dallas, Texas, United States, 75390

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Active diagnosis of amnestic mild cognitive impairment
  • 2. Presence of an mTBI history for the mTBI+ group; absence of an mTBI history for a control sample
  • 3. Female and male subjects
  • 4. All races/ethnicities
  • 5. Age 55 years and older
  • 6. Fluent in English
  • 1. Mild traumatic brain injury within past year
  • 2. Lifetime history of moderate or severe brain injury
  • 3. Lifetime major neurologic syndromes (e.g., stroke, epilepsy, brain tumor)
  • 4. Lifetime major cardiovascular conditions (e.g., heart attack, heart failure)
  • 5. Current substance use disorder
  • 6. Current major psychiatric disorders (e.g., major depressive disorder, bipolar disorder)
  • 7. Current vision or hearing impairment that interferes with testing
  • 8. Any electronic and or metallic implants in the skull or brain
  • 9. Current medication use known to alter HD-tDCS reactivity

Ages Eligible for Study

55 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Texas Southwestern Medical Center,

Study Record Dates

2027-05-31