RECRUITING

InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer

Description

This research study is creating a way to collect and store specimens and information from participants who may be at an increased risk of developing cancer, or has been diagnosed with an early phase of a cancer or a family member who has a family member with a precursor condition for cancer. * The objective of this study is to identify exposures as well as clinical, molecular, and pathological changes that can be used to predict early development of cancer, malignant transformation, and risks of progression to symptomatic cancer that can ultimately be fatal. * The ultimate goal is to identify novel markers of early detection and risk stratification to drive potential therapeutic approaches to intercept progression to cancer.

Conditions

Cancer RiskCancer Predisposition SyndromeHereditary Cancer PredictionChildhood Cancer SurvivorsAdult Cancer SurvivorsIARC CarcinogensSmoking HistoryLung CancerDuctal/Lobular CarcinomaBarrett EsophagusPancreatic Precursor LesionsColonic Dysplasia/AdenomataNon-Alcoholic Fatty Liver DiseaseNon Alcoholic SteatohepatitisCirrhosisHigh Grade Prostatic Epithelial NeoplasiaHigh-grade Bladder Urothelial Dysplasia/Carcinoma in SituAdenomatous HyperplasiaHigh-risk Oral Precancerous DiseasesMelanocytic Lesion, AdultHematologic MalignancyLung; NodeSerous Tubal Intraepithelial CarcinomaEndometrial Intraepithelial NeoplasiaCervical and Endocervical Carcinoma in SituVulvar Intraepithelial NeoplasiaNephrogenic RestsBenign Bone Lesions With Risk of Malignant DegenerationGiant Cell TumorOsteochondromaSpitz Nevus
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Related Conditions:

Cancer RiskCancer Predisposition SyndromeHereditary Cancer PredictionChildhood Cancer SurvivorsAdult Cancer SurvivorsIARC CarcinogensSmoking HistoryLung CancerDuctal/Lobular CarcinomaBarrett EsophagusPancreatic Precursor LesionsColonic Dysplasia/AdenomataNon-Alcoholic Fatty Liver DiseaseNon Alcoholic SteatohepatitisCirrhosisHigh Grade Prostatic Epithelial NeoplasiaHigh-grade Bladder Urothelial Dysplasia/Carcinoma in SituAdenomatous HyperplasiaHigh-risk Oral Precancerous DiseasesMelanocytic Lesion, AdultHematologic MalignancyLung; NodeSerous Tubal Intraepithelial CarcinomaEndometrial Intraepithelial NeoplasiaCervical and Endocervical Carcinoma in SituVulvar Intraepithelial NeoplasiaNephrogenic RestsBenign Bone Lesions With Risk of Malignant DegenerationGiant Cell TumorOsteochondromaSpitz Nevus

Study Overview

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Study Details

Study overview

This research study is creating a way to collect and store specimens and information from participants who may be at an increased risk of developing cancer, or has been diagnosed with an early phase of a cancer or a family member who has a family member with a precursor condition for cancer. * The objective of this study is to identify exposures as well as clinical, molecular, and pathological changes that can be used to predict early development of cancer, malignant transformation, and risks of progression to symptomatic cancer that can ultimately be fatal. * The ultimate goal is to identify novel markers of early detection and risk stratification to drive potential therapeutic approaches to intercept progression to cancer.

InAdvance: Surveillance, Prevention, and Interception in a Population at Risk For Cancer

InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer

Condition
Cancer Risk
Intervention / Treatment

-

Contacts and Locations

Boston

Dana Farber Cancer Institute, Boston, Massachusetts, United States, 02115

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Participants to be included in this study include the following (note that this list is not comprehensive but gives examples of precursor conditions for each organ type):
  • * Carriers of known or previously unrecognized pathogenic germline variants of cancer predisposing genes
  • * Individuals with personal or family history suggestive of elevated cancer risk (this may include individuals who have negative genetic testing results or have not elected to undergo testing)
  • * Individuals with a clinically based diagnosis of a Cancer Predisposition Syndrome (examples, neurofibromatosis, Fanconi Anemia, Ataxia-Telangiectasia)
  • * Hereditary Cancer Prediction Model-based elevated cancer risk
  • * Others at risk for specific cancers by virtue of exposure, obesity, gender, race and ethnicity, HPV exposure (for H\&N cancer for example), etc.
  • * Exposed High Risk including
  • * Childhood cancer survivors with treatment exposures associated with increased risk of cancer
  • * Adult cancer survivors with treatment exposures associated with increased risk of cancer
  • * Documented high level exposure to group 1 IARC carcinogens
  • * Thoracic: individuals at risk for lung cancer including but not exclusive of the following criteria: Age \>50, Smoking history of \>15 pack years, First-degree relative history of lung cancer or COPD
  • * alcoholic liver disease (NAFL), non-alcoholic steatohepatitis (NASH), cirrhosis
  • * Precursor Lesions including
  • * Breast: ductal/lobular carcinoma in situ (CIS) and atypical hyperplasia
  • * GI: Barrett's esophagus, Pancreatic precursor lesions, colonic dysplasia/adenomata, nonalcoholic fatty liver (NAFL), nonalcoholic steatohepatitis (NASH), cirrhosis
  • * GU: High grade prostatic epithelial neoplasia, and high-grade bladder urothelial dysplasia/carcinoma in situ,
  • * Lung: Adenomatous hyperplasia
  • * H\&N: high-risk oral precancerous diseases
  • * Skin: Class II melanocytic lesions. Squamous dysplasia
  • * Heme malignancies: CHIP, CCUS, ICUS, MGUS, SMM, SWM, MBL (spell these out), Low grade lymphomas
  • * Thoracic: Lung nodules detected on screening CT that prompt further follow-up
  • * GYN: STIC lesion (serous tubal intraepithelial carcinoma), Endometrial intraepithelial neoplasia, Cervical and endocervical carcinoma in situ, vulvar intraepithelial neoplasia
  • * Pediatric histologic diagnoses sometimes associated with development of malignancy: Nephrogenic rests, benign bone lesions with risk of malignant degeneration (Giant cell tumor, osteochondroma), Spitz nevus, and others.
  • * FAMILY MEMBERS or healthy individuals

Ages Eligible for Study

to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Dana-Farber Cancer Institute,

Sapna Syngal, MD, PRINCIPAL_INVESTIGATOR, Dana-Farber Cancer Institute

Study Record Dates

2032-03-25