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Arginine Metabolism in Youth With Type 2 Diabetes

Description

Type 2 diabetes (T2D), once considered only "a disease of older ages," is now a significant public health concern in youth. Although it is characterized by insulin resistance and impaired insulin secretion, its precise etiology and pathogenesis are not yet fully understood. This study aims to (1) explore arginine metabolism in youth with T2D via safe, minimally invasive kinetic experiments using stable isotope tracers and targeted metabolomics, and (2) determine the effect of exogenous arginine administration on β-cell function in youth with T2D, potentially supporting the use of this safe, low-cost, and readily available nutrient to improve pediatric diabetes outcomes.

Conditions

Type 2 Diabetes
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Related Conditions:

Type 2 Diabetes

Study Overview

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Study Details

Study overview

Type 2 diabetes (T2D), once considered only "a disease of older ages," is now a significant public health concern in youth. Although it is characterized by insulin resistance and impaired insulin secretion, its precise etiology and pathogenesis are not yet fully understood. This study aims to (1) explore arginine metabolism in youth with T2D via safe, minimally invasive kinetic experiments using stable isotope tracers and targeted metabolomics, and (2) determine the effect of exogenous arginine administration on β-cell function in youth with T2D, potentially supporting the use of this safe, low-cost, and readily available nutrient to improve pediatric diabetes outcomes.

Arginine Metabolism in Pediatric Type 2 Diabetes

Arginine Metabolism in Youth With Type 2 Diabetes

Condition
Type 2 Diabetes
Intervention / Treatment

-

Contacts and Locations

Houston

Texas Children's Hospital / Baylor College of Medicine, Houston, Texas, United States, 77030

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Youth with type 2 diabetes and healthy controls who meet other inclusion criteria outlined below.
  • 2. Age and pubertal stage criteria (12- to 20-year-old girls who are postmenarchal, and 14- to 20-year-old boys who are at Tanner stage 5 genitalia),
  • 3. Additional criteria for youth with diabetes: i. diagnosis of T2D, and ii. diabetes duration between 3 months and 10 years.
  • 1. Previous history of diabetic ketoacidosis (DKA)
  • 2. Current use of exogenous insulin,
  • 3. Poorly controlled diabetes defined as HbA1c \>8%,
  • 4. Abnormal liver, thyroid, gonadal or adrenal functions,
  • 5. Renal insufficiency defined by eGFR (estimated glomerular filtration rate) \<90 mL/min/1.73 m2,
  • 6. Any glucose lowering medications except metformin,
  • 7. Any medication use that will likely to interfere amino acid metabolism,
  • 8. Any hormonal replacement therapy, and
  • 9. Pregnancy.

Ages Eligible for Study

12 Years to 20 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Baylor College of Medicine,

Mustafa Tosur, MD, PRINCIPAL_INVESTIGATOR, Baylor College of Medicine

Study Record Dates

2027-08-31