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Transcranial Direct Current Stimulation Potentiation of Fear Extinction in OCD

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Conditions

Obsessive-Compulsive DisorderOCDFear extinctiontDCStranscranial Direct Current StimulationRandomized controlled trialFear conditioning

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The investigators want to learn more about how human beings learn not to fear and the impact of changing the fear network in the brain using transcranial Direct Current Stimulation (tDCS) in individuals with obsessive compulsive disorder (OCD). The investigators hope this study will help us understand how future treatments can help patients with OCD better control unwanted fear.

Official Title

Transcranial Direct Current Stimulation Potentiation of Fear Extinction in OCD: Towards Rational Design of Combination Therapies

Quick Facts

Study Start:2022-09-15
Study Completion:2025-07-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT05521074

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 60 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Fluent in English, willing to provide informed consent, and willing to comply with the study protocol
  2. * Primary OCD that causes at least moderate distress and/or impairment (Y-BOCS total score ≥ 16)
  3. * Comfortable and capable of using a computer and completing computerized tasks
  1. * History of head injury resulting in prolonged (i.e., \>1h) loss of consciousness and/or neurological sequelae; history of stroke; signs of increased intracranial pressure; prior neurosurgical procedure (e.g., DBS, aneurysm clips)
  2. * Contraindications to participate in tDCS including: metallic implants in head or neck; ventriculoperitoneal (VP) shunts; pacemakers; pregnancy; epilepsy.
  3. * Current or history of neurologic or psychiatric disease (e.g., mental retardation, dementia, brain damage, or other cognitive impairment) that would interfere with ability to participate in the study
  4. * Impaired (or uncorrected) vision that would interfere with participation.
  5. * Current clinically significant suicidality that requires psychiatric hospitalization, as indicated by clinical judgment.
  6. * Current substance use disorder (within the past 12 months)
  7. * Lifetime manic episode or psychosis
  8. * Documented resistance to 4 or more valid pharmacological trials and previous treatment with ≥12 sessions of cognitive behavioral therapy for OCD with no response (or worsening symptoms)
  9. * Use of most psychotropic medications (e.g., SSRIs and atypical antipsychotics) will be allowed. However, use of benzodiazepines within 2 weeks prior to the study is exclusionary (and participants will be asked to refrain from use of such medications during the study as they may interfere with the fear extinction paradigm).
  10. * Unable to obtain low enough impedance values to ensure safe and effective application of tDCS/EEG.

Contacts and Locations

Principal Investigator

Joan Camprodon, MD, MPH, PhD
PRINCIPAL_INVESTIGATOR
Massachusetts General Hospital

Study Locations (Sites)

Massachusetts General Hospital
Boston, Massachusetts, 02114
United States

Collaborators and Investigators

Sponsor: Massachusetts General Hospital

  • Joan Camprodon, MD, MPH, PhD, PRINCIPAL_INVESTIGATOR, Massachusetts General Hospital

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-09-15
Study Completion Date2025-07-31

Study Record Updates

Study Start Date2022-09-15
Study Completion Date2025-07-31

Terms related to this study

Keywords Provided by Researchers

  • Obsessive-Compulsive Disorder
  • OCD
  • Fear extinction
  • tDCS
  • transcranial Direct Current Stimulation
  • Randomized controlled trial
  • Fear conditioning

Additional Relevant MeSH Terms

  • Obsessive-Compulsive Disorder