RECRUITING

Noninvasive Brain Stimulation to Enhance Reading Comprehension Ability in Adults

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this project is to address the urgent need for effective, scalable adult literacy interventions by integrating breakthroughs in two separate fields: 1.) the brain network science of resilience to reading disorders and 2.) high-definition non-invasive brain network stimulation. This study will first establish the efficacy of a novel, noninvasive stimulation protocol on reading behavior and brain metrics; then will determine how stimulation-induced effects interact with baseline reading comprehension ability; and lastly, will identify whether stimulation-induced effects are more clinically-beneficial than canonical behavioral interventions. Results may change the foundation for how we treat low adult literacy, and have the potential for wider reaching impacts on non-invasive stimulation protocols for other clinical disorders.

Official Title

Bridging the Gap Between Brain Network Science and High-definition Non-invasive Brain Stimulation to Develop a Scalable Adult Literacy Intervention

Quick Facts

Study Start:2022-11-07
Study Completion:2026-08-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05523505

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 40 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * This study will be open to all right-handed native English monolingual speakers who meet eligibility criteria regardless of race, gender, minority or socioeconomic status. Due to age-related differences in the language and learning processes, the age range of subjects will be a minimum of 18 years and a maximum of 40 years.
  1. * previous diagnosis of Intellectual Disability;
  2. * known uncorrectable visual impairment;
  3. * documented hearing impairment greater than or equal to a 25 dB loss;
  4. * medical contraindication to MRI procedures (e.g., metal devices);
  5. * known IQ below 70;
  6. * a pervasive developmental disorder;
  7. * any known neurologic pathology, including epilepsy, spina bifida, cerebral palsy, traumatic brain injury, and brain tumors;
  8. * recent diagnosis of migraines;
  9. * pregnancy;
  10. * history of syncope;
  11. * severe fatigue,
  12. * bilingualism or low English proficiency;
  13. * poor reading ability that will prevent completion of the tasks; and
  14. * comorbid severe psychiatric disorders will be excluded, as will those who are taking psychotropic medications or medications known to increase the risk of seizures or strokes.
  15. * participants taking medication known to cause stroke or seizures
  16. * hair styles that do not allow for proper EEG net fitting, or that pose potential risks for damage to EEG net

Contacts and Locations

Study Contact

Tess Fotidzis, PhD
CONTACT
615-601-1311
tess.s.fotidzis@vanderbilt.edu

Principal Investigator

Katherine S. Aboud, PhD
PRINCIPAL_INVESTIGATOR
Vanderbilt University

Study Locations (Sites)

Vanderbilt University Medical Center
Nashville, Tennessee, 37203
United States

Collaborators and Investigators

Sponsor: Vanderbilt University

  • Katherine S. Aboud, PhD, PRINCIPAL_INVESTIGATOR, Vanderbilt University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-11-07
Study Completion Date2026-08-31

Study Record Updates

Study Start Date2022-11-07
Study Completion Date2026-08-31

Terms related to this study

Keywords Provided by Researchers

  • Neuroimaging
  • Adults
  • Non-invasive Brain Stimulation
  • Reading
  • Reading Comprehension

Additional Relevant MeSH Terms

  • Reading Disability