RECRUITING

Molecular and Clinical Risk-Directed Therapy for Infants and Young Children With Newly Diagnosed Medulloblastoma

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Conditions

MedulloblastomaSJiMB21Brain CancerBrain Tumors in ChildrenMedulloblastoma Sonic Hedgehog subgroup 1Medulloblastoma Sonic Hedgehog subgroup 2Medulloblastoma Sonic Hedgehog subgroup 3Medulloblastoma Sonic Hedgehog subgroup 4Medulloblastoma Sonic Hedgehog-not otherwise specifiedMedulloblastoma G3Medulloblastoma G4Medulloblastoma indeterminateMLPNetNeural Net Classification PipelineNon-WNT non-SHH medulloblastomaPosterior fossa syndromeSt. Jude Brain Tumor StudiesTreatment for Brain Tumors in Infants and Young ChildrenUntreated Childhood Medulloblastoma

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is a multi-center, multinational phase 2 trial that aims to explore the use of molecular and clinical risk-directed therapy in treatment of children 0-4.99 years of age with newly diagnosed medulloblastoma.

Official Title

SJiMB21: Phase 2 Study of Molecular and Clinical Risk-Directed Therapy for Infants and Young Children With Newly Diagnosed Medulloblastoma

Quick Facts

Study Start:2022-12-20
Study Completion:2035-07
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05535166

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:Not specified to 59 Months
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Tabatha E. Doyle, RN
CONTACT
901-595-2544
tabatha.doyle@stjude.org
Jean Laboe, MSN, RN
CONTACT
901-595-1693
jean.laboe@stjude.org

Principal Investigator

Giles W. Robinson, MD
PRINCIPAL_INVESTIGATOR
St. Jude Children's Research Hospital
Aditi Bagchi, MD, PhD
PRINCIPAL_INVESTIGATOR
St. Jude Children's Research Hospital

Study Locations (Sites)

Lucille Packard Children's Hospital at Stanford University
Palo Alto, California, 94304
United States
Orlando Health Arnold Palmer Hospital for Children
Orlando, Florida, 32806
United States
St. Joseph's Children's Hospital
Tampa, Florida, 33607
United States
C.S. MOTT Children's Hospital, University of Michigan
Ann Arbor, Michigan, 48109
United States
Children's Hospital and Clinics of Minnesota
Minneapolis, Minnesota, 55404
United States
St. Jude Children's Research Hospital
Memphis, Tennessee, 38105
United States
UT Southwestern/Simmons Cancer Center
Dallas, Texas, 75235
United States
Cook Children's Medical Center
Fort Worth, Texas, 76104
United States
Texas Children's Hospital
Houston, Texas, 77477
United States
Primary Children's Hospital
Salt Lake City, Utah, 84113
United States

Collaborators and Investigators

Sponsor: St. Jude Children's Research Hospital

  • Giles W. Robinson, MD, PRINCIPAL_INVESTIGATOR, St. Jude Children's Research Hospital
  • Aditi Bagchi, MD, PhD, PRINCIPAL_INVESTIGATOR, St. Jude Children's Research Hospital

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-12-20
Study Completion Date2035-07

Study Record Updates

Study Start Date2022-12-20
Study Completion Date2035-07

Terms related to this study

Keywords Provided by Researchers

  • SJiMB21
  • Brain Cancer
  • Brain Tumors in Children
  • Medulloblastoma Sonic Hedgehog subgroup 1
  • Medulloblastoma Sonic Hedgehog subgroup 2
  • Medulloblastoma Sonic Hedgehog subgroup 3
  • Medulloblastoma Sonic Hedgehog subgroup 4
  • Medulloblastoma Sonic Hedgehog-not otherwise specified
  • Medulloblastoma G3
  • Medulloblastoma G4
  • Medulloblastoma indeterminate
  • MLPNet
  • Neural Net Classification Pipeline
  • Non-WNT non-SHH medulloblastoma
  • Posterior fossa syndrome
  • St. Jude Brain Tumor Studies
  • Treatment for Brain Tumors in Infants and Young Children
  • Untreated Childhood Medulloblastoma

Additional Relevant MeSH Terms

  • Medulloblastoma