RECRUITING

Chardonnay Marc and Vascular Response

Description

This study aims to obtain data on the potential influence of Vine to Bar product(s) containing Chardonnay marc on cardiometabolic health. These initial studies will inform the design and timing of data collection for future dietary intervention trials that will examine the influence of Chardonnay marc intake on outcomes/biomarkers of both cardiometabolic health and the gut microbiome. This includes collecting data on the potential differences in response to the products based on the unique food matrix for each of the products that will be tested. Moreover, as there is a paucity of data on the influence of cocoa flavanol intake on vascular function beyond 4 hours post intake, the response of the selected outcomes will be assessed after 6 hours of flavanol intake. This is a time point that captures the increased circulating presence of microbial derived flavanol metabolites.

Conditions

Cardiovascular DiseasesVascular DilationOxidative Stress
Talk to us

Related Conditions:

Cardiovascular DiseasesVascular DilationOxidative Stress

Study Overview

On this page

Study Details

Study overview

This study aims to obtain data on the potential influence of Vine to Bar product(s) containing Chardonnay marc on cardiometabolic health. These initial studies will inform the design and timing of data collection for future dietary intervention trials that will examine the influence of Chardonnay marc intake on outcomes/biomarkers of both cardiometabolic health and the gut microbiome. This includes collecting data on the potential differences in response to the products based on the unique food matrix for each of the products that will be tested. Moreover, as there is a paucity of data on the influence of cocoa flavanol intake on vascular function beyond 4 hours post intake, the response of the selected outcomes will be assessed after 6 hours of flavanol intake. This is a time point that captures the increased circulating presence of microbial derived flavanol metabolites.

Preclinical Trials to Determine the Range of Chardonnay Mark Intake for Improved Metabolic and Vascular Response.

Chardonnay Marc and Vascular Response

Condition
Cardiovascular Diseases
Intervention / Treatment

-

Contacts and Locations

Davis

Academic Surge, University of California, Davis, Davis, California, United States, 95616

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Screening or Visit 1 Reactive Hyperemia Index (RHI; EndoPAT 2000) \< 2.0
  • * Subject is willing and able to comply with the study protocols.
  • * Subject is willing to participate in all study procedures
  • * BMI 25.0 - 35 kg/m2
  • * BMI ≥ 35 kg/m2
  • * Indivduals that weight less than a 110 lbs
  • * Donation of blood within the previous 30 days
  • * Visit 1 Reactive Hyperemia Index (RHI; EndoPAT 2000) ≥ 2.0
  • * 1 ug/ml and 3 ug/ml collagen screening maximal platelet aggregatory response of \< 65%.
  • * Platelet counts \< 150,000 / ul
  • * Anemia, which includes self report, or a screening hemoglobin and hematocrit that is less than the normal reference range or as diagnosed by study physician upon review of complete blood cell count reports.
  • * Dislike or allergy for nuts, cocoa or grape products
  • * Self-reported use of daily anticoagulation agents including aspirin, NSAIDs
  • * Vegan, Vegetarians, food faddists or those consuming a non-traditional diet
  • * Fruit consumption ≥ 3 cups/day
  • * Vegetable consumption ≥ 4 cups/day
  • * Nut intake ≥ 2 servings/ week
  • * Coffee/tea ≥ 3 cups/day
  • * Dark chocolate ≥ 3 oz/day
  • * Self-reported restriction of physical activity due to a chronic health condition
  • * Self-reported chronic/routine high intensity exercise
  • * Self-reported diabetes
  • * Blood pressure ≥ 140/90 mm Hg
  • * Self-reported renal or liver disease
  • * Self-reported heart disease, which includes cardiovascular events and stroke
  • * Peripheral artery disease, Raynaud's syndrome
  • * Inability to properly place or wear the PAT probes or abnormal measurements on pre- screening PAT
  • * Self-reported cancer within past 5 years
  • * Self-reported malabsorption
  • * Currently taking prescription drugs or supplements.
  • * Supplement use or unwillingness to stop any supplement use, including herbal, plant or botanical, fish oil, oil supplements a month prior to study enrollment.
  • * Indications of substance or alcohol abuse within the last 3 years
  • * smoking, vaping, cannabis use
  • * Current enrollee in a clinical research study.

Ages Eligible for Study

30 Years to 50 Years

Sexes Eligible for Study

MALE

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of California, Davis,

Carl L Keen, PRINCIPAL_INVESTIGATOR, Distinguished Professor Emeritus of Nutrition

Study Record Dates

2024-12-31