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Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

Description

This ComboMATCH patient screening trial is the gateway to a coordinated set of clinical trials to study cancer treatment directed by genetic testing. Patients with solid tumors that have spread to nearby tissue or lymph nodes (locally advanced) or have spread to other places in the body (advanced) and have progressed on at least one line of standard systemic therapy or have no standard treatment that has been shown to prolong overall survival may be candidates for these trials. Genetic tests look at the unique genetic material (genes) of patients' tumor cells. Patients with some genetic changes or abnormalities (mutations) may benefit from treatment that targets that particular genetic mutation. ComboMATCH is designed to match patients to a treatment that may work to control their tumor and may help doctors plan better treatment for patients with locally advanced or advanced solid tumors.

Conditions

Advanced Malignant Solid NeoplasmAnatomic Stage III Breast Cancer AJCC v8Anatomic Stage IV Breast Cancer AJCC v8Locally Advanced Malignant Solid NeoplasmMalignant Female Reproductive System NeoplasmMetastatic HER2-Negative Breast CarcinomaMetastatic Malignant Solid NeoplasmRecurrent Endometrial CarcinomaRecurrent Fallopian Tube CarcinomaRecurrent Malignant Female Reproductive System NeoplasmRecurrent Malignant Solid NeoplasmRecurrent Ovarian CarcinomaRecurrent Primary Peritoneal CarcinomaUnresectable HER2-Negative Breast CarcinomaUnresectable Malignant Solid Neoplasm
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Related Conditions:

Advanced Malignant Solid NeoplasmAnatomic Stage III Breast Cancer AJCC v8Anatomic Stage IV Breast Cancer AJCC v8Locally Advanced Malignant Solid NeoplasmMalignant Female Reproductive System NeoplasmMetastatic HER2-Negative Breast CarcinomaMetastatic Malignant Solid NeoplasmRecurrent Endometrial CarcinomaRecurrent Fallopian Tube CarcinomaRecurrent Malignant Female Reproductive System NeoplasmRecurrent Malignant Solid NeoplasmRecurrent Ovarian CarcinomaRecurrent Primary Peritoneal CarcinomaUnresectable HER2-Negative Breast CarcinomaUnresectable Malignant Solid Neoplasm

Study Overview

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Study Details

Study overview

This ComboMATCH patient screening trial is the gateway to a coordinated set of clinical trials to study cancer treatment directed by genetic testing. Patients with solid tumors that have spread to nearby tissue or lymph nodes (locally advanced) or have spread to other places in the body (advanced) and have progressed on at least one line of standard systemic therapy or have no standard treatment that has been shown to prolong overall survival may be candidates for these trials. Genetic tests look at the unique genetic material (genes) of patients' tumor cells. Patients with some genetic changes or abnormalities (mutations) may benefit from treatment that targets that particular genetic mutation. ComboMATCH is designed to match patients to a treatment that may work to control their tumor and may help doctors plan better treatment for patients with locally advanced or advanced solid tumors.

Molecular Analysis for Combination Therapy Choice (ComboMATCH)

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

Condition
Advanced Malignant Solid Neoplasm
Intervention / Treatment

-

Contacts and Locations

Birmingham

University of Alabama at Birmingham Cancer Center, Birmingham, Alabama, United States, 35233

Mobile

University of South Alabama Mitchell Cancer Institute, Mobile, Alabama, United States, 36688

Goodyear

CTCA at Western Regional Medical Center, Goodyear, Arizona, United States, 85338

Kingman

Kingman Regional Medical Center, Kingman, Arizona, United States, 86401

Phoenix

Mayo Clinic Hospital in Arizona, Phoenix, Arizona, United States, 85054

Arroyo Grande

PCR Oncology, Arroyo Grande, California, United States, 93420

Carmichael

Mercy Cancer Center - Carmichael, Carmichael, California, United States, 95608

Carmichael

Mercy San Juan Medical Center, Carmichael, California, United States, 95608

Dublin

Epic Care-Dublin, Dublin, California, United States, 94568

Elk Grove

Mercy Cancer Center - Elk Grove, Elk Grove, California, United States, 95758

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patient must have measurable disease
  • * Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status between 0-2 OR patient must have Lansky performance status of \>= 50% or Karnofsky performance status of \>= 50%
  • * Patient must be deemed potentially eligible for a ComboMATCH Treatment Trial as assessed by the enrolling provider
  • * All patients must have sequencing results available from a National Cancer Institute (NCI) credentialed Designated Laboratory (DL)
  • * Patients must have locally advanced or advanced histologically documented solid tumors requiring therapy and meet one of the following criteria:
  • * Patients must have progressed on at least one line of standard systemic therapy OR
  • * Patients whose disease has no standard treatment that has been shown to prolong overall survival
  • * Patient must meet one of the following requirements:
  • * Patients 18 years and older who have tumor amenable to minimal risk image-guided or direct vision biopsy and must be willing and able to undergo a tumor biopsy to obtain samples for research if the patient is to enroll in a ComboMATCH treatment trial OR
  • * Patients 18 years and older who do not have disease that is biopsiable at minimal risk to the patient must confirm availability of an archival tumor tissue specimen for submission for research if the patient enrolls to a ComboMATCH Treatment Trial. This tumor tissue must meet the following criteria:
  • * Tissue must have been collected within 12 months prior to registration to the EAY191 Registration Trial
  • * Patient must not have had a Response Evaluation Criteria in Solid Tumors (RECIST) response (complete response \[CR\] or partial response \[PR\]) to any intervening therapy after collection of the tissue
  • * Formalin-fixed paraffin-embedded tumor tissue block(s) or slides must be available OR
  • * Patients under 18 years old must confirm availability of an archival tumor tissue specimen for submission for research if patient enrolls to a ComboMATCH Treatment Trial. This tumor tissue must meet the following criteria:
  • * Formalin-fixed paraffin-embedded tumor tissue block(s) or slides must be available
  • * NOTE: See specific ComboMATCH Treatment Trial protocol for tissue collection and management instructions. Performance of the mandatory research biopsy or submission of pre-trial formalin-fixed paraffin-embedded (FFPE) and collection and submission of the blood specimens for the integrated studies will be performed under the consent authority of the specific treatment trial protocol to which the patient is registered. No procedures to collect specimens for research only are to be performed for patients registered to the EAY191 Registration Trial only
  • * NOTE: Each ComboMATCH Treatment Trial contains specific eligibility criteria. If patient is found to not be eligible for the assigned ComboMATCH Treatment Trial, indication of ineligibility will trigger re-evaluation and potential assignment to another Treatment Trial

Ages Eligible for Study

to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

National Cancer Institute (NCI),

James M Ford, PRINCIPAL_INVESTIGATOR, ECOG-ACRIN Cancer Research Group

Study Record Dates

2030-07-01