RECRUITING

Operant Conditioning of the Soleus Stretch Reflex in Adults With Cerebral Palsy

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

12 adults with spastic CP will complete 6 baseline sessions and 24 down conditioning sessions held 3 times/week. All clinical and physiological assessments collected at baseline will be reassessed after study completion, and follow ups after 2 weeks, 1 month and 3 months. The soleus H reflex (electric analogue of the stretch reflex) will be elicited in all sessions. In each session, participants will complete 20 baseline trials and 225 down conditioning trials to decrease the magnitude of the H-Reflex.

Official Title

Operant Conditioning of the Soleus Stretch Reflex in Adults With Cerebral Palsy

Quick Facts

Study Start:2022-09-30
Study Completion:2026-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05571033

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Age 18 and above
  2. 2. Diagnosis of spastic Cerebral Palsy
  3. 3. Gross Motor Function Classification System level I-III
  4. 4. Stable medical background
  5. 5. Current medication will remain unchanged for 3 months
  6. 6. Provides informed consent
  7. 7. can walk at least 10 meters with or without assistive device
  8. 8. meets minimum study procedure requirements (elicitation of H-reflex).
  1. 1. Pregnancy
  2. 2. uncontrolled diabetes
  3. 3. weak dorsiflexion
  4. 4. History of cardiac conditions
  5. 5. cognitive deficits that interfere with study procedure and steps for completion
  6. 6. Botox within 2 months of the study
  7. 7. H/O ankle surgeries in affected leg (Dorsal root rhizotomy etc.)
  8. 8. regular use of electrical stimulation to lower extremity muscles
  9. 9. Cochlear or metal implantations on body
  10. 10. No history of seizure after age 2 years
  11. 11. Current use of antiseizure medicines
  12. 12. Any metal or magnetic components in the head (surgical clips, metal work etc.)
  13. 13. Implanted device or cardiac pacemakers (applicable for DS8R too)
  14. 14. Skin disorders
  15. 15. Damaged skin (wounds, broken skin, or recent scar tissue)
  16. 16. Allergy to latex (tape)

Contacts and Locations

Study Contact

Devina Kumar, PhD
CONTACT
914-368-3160
dek4004@med.cornell.edu

Principal Investigator

Kathleen Friel, PhD
PRINCIPAL_INVESTIGATOR
Burke Neurological Institute

Study Locations (Sites)

Burke Neurological Institute
White Plains, New York, 10605
United States

Collaborators and Investigators

Sponsor: Burke Medical Research Institute

  • Kathleen Friel, PhD, PRINCIPAL_INVESTIGATOR, Burke Neurological Institute

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-09-30
Study Completion Date2026-12-31

Study Record Updates

Study Start Date2022-09-30
Study Completion Date2026-12-31

Terms related to this study

Keywords Provided by Researchers

  • Hoffman Reflex
  • Spinal Reflex Conditioning

Additional Relevant MeSH Terms

  • Cerebral Palsy
  • Spastic Cerebral Palsy