RECRUITING

Paired tVNS With ERP in OCD

Description

In the proposed investigation, the investigator will develop pilot data for the use of tVNS (transcutaneous vagal nerve stimulation) to enhance efficacy of exposure and response prevention therapy (ERP) to improve treatment success in patients with OCD. This data will include tolerability information from therapists and patients with OCD, effect sizes on real world clinical outcomes for the combinatory treatment, and mechanistic data on brain changes associated with treatment.

Conditions

OCD
Talk to us

Related Conditions:

OCD

Study Overview

On this page

Study Details

Study overview

In the proposed investigation, the investigator will develop pilot data for the use of tVNS (transcutaneous vagal nerve stimulation) to enhance efficacy of exposure and response prevention therapy (ERP) to improve treatment success in patients with OCD. This data will include tolerability information from therapists and patients with OCD, effect sizes on real world clinical outcomes for the combinatory treatment, and mechanistic data on brain changes associated with treatment.

Pairing tVNS and Exposure and Response Prevention to Improve Symptoms of OCD

Paired tVNS With ERP in OCD

Condition
OCD
Intervention / Treatment

-

Contacts and Locations

Gainesville

University of Florida, Gainesville, Florida, United States, 32610

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Adults between the ages of 18 and 55
  • * Meet DSM-5 criteria for OCD, based on a structured clinical interview and who have a YBOCS score of 15 or higher, indicating at least moderate OCD severity
  • * Participants must be willing and able to provide informed consent.
  • * Participants with major neurological conditions, autism spectrum disorder, psychosis, major uncorrected sensory deficit, and severe medical disease that may be associated with neurological effects.
  • * People with an active eating disorder that requires treatment, but we will not exclude people who are in remission.
  • * Current illicit or prescription drug abuse
  • * Participants who are receiving pharmacotherapy for their OCD or for other psychiatric disorders will not be excluded
  • * No medication changes will be allowed during the study, and participants must be on stable doses of medications for at least 6 weeks prior to entering the study. Prior ERP treatment (at least 12 months removed) is acceptable

Ages Eligible for Study

18 Years to 55 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Florida,

John Williamson, PhD, PRINCIPAL_INVESTIGATOR, University of Florida

Study Record Dates

2025-09-30