RECRUITING

Study of RYZ101 in Combination With SoC in Subjects With SSTR+ ES-SCLC

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study aims to determine the safety, preliminary antitumor activity, and pharmacokinetics (PK) of RYZ101 in combination with standard of care (SoC) therapy consisting of carboplatin + etoposide + atezolizumab in untreated subjects with somatostatin receptor expressing (SSTR+) ES-SCLC.

Official Title

Phase 1b Single Arm, Open-label Trial of RYZ101 in Combination With Carboplatin + Etoposide + Atezolizumab in Subjects With Somatostatin Receptor Expressing (SSTR+) Extensive Stage Small Cell Lung Cancer (ES-SCLC)

Quick Facts

Study Start:2022-10-10
Study Completion:2026-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05595460

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

RayzeBio Clinical Trials
CONTACT
619-657-0302
clinicaltrials@rayzebio.com

Principal Investigator

Denise Ferreira, MD
STUDY_DIRECTOR
RayzeBio, Inc.

Study Locations (Sites)

Research Facility
Los Angeles, California, 90024
United States
Research Facility
San Francisco, California, 94158
United States
Research Facility
Jacksonville, Florida, 32224
United States
Research Facility
Orlando, Florida, 32806
United States
Research Facility
Grand Rapids, Michigan, 49503
United States
Research Facility
Troy, Michigan, 48098
United States
Research Facility
Rochester, Minnesota, 55905
United States
Research Facility
Omaha, Nebraska, 68130
United States
Research Facility
Houston, Texas, 77090
United States
Research Facility
Salt Lake City, Utah, 84112
United States

Collaborators and Investigators

Sponsor: RayzeBio, Inc.

  • Denise Ferreira, MD, STUDY_DIRECTOR, RayzeBio, Inc.

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-10-10
Study Completion Date2026-12

Study Record Updates

Study Start Date2022-10-10
Study Completion Date2026-12

Terms related to this study

Keywords Provided by Researchers

  • actinium
  • alpha-emitter
  • SSTR+ ES-SCLC
  • SCLC
  • ES-SCLC
  • RYZ101
  • 225Ac
  • 225Ac-DOTATATE
  • targeted radiotherapy
  • atezolizumab
  • carboplatin
  • etoposide
  • radiopharmaceutical

Additional Relevant MeSH Terms

  • SCLC,Extensive Stage