RECRUITING

Comparing Intubation Rates in the Delivery Room by Interface

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Although the majority of premature neonates \< 30 weeks gestion require positive pressure ventilation (PPV) at birth, the optimal interface to provide PPV has not been determined. Preferably this support would be provided by non-invasive means to prevent the development of bronchopulmonary dysplasia. Resuscitation with a face mask, single nasal tube, nasal prongs, and/or LMA are all approved methods of resuscitation per NRP as of 2010. Face masks have been associated with more dead space, air leak and airway obstruction however are the most commonly used interface. Recently, the Trigeminal Cardiac Reflex has been described, which can be induced with the placement of a facemask, resulting in bradycardia and apnea. Bi-nasal prongs (RAM cannula) have been found in studies to be associated with lower intubation rates in the delivery room (down to 24 weeks gestation), less need for epinephrine, chest compressions, and subsequent invasive ventilation. In addition to the potential practical advantages of bi-nasal prong resuscitation, there is evidence to suggest that ventilation through the nose may stimulate the subepithelial receptors of the upper airways causing an increase in respiratory rate and depth.

Official Title

Comparing Intubation Rates in the Delivery Room by Interface

Quick Facts

Study Start:2022-09-22
Study Completion:2025-09-22
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05609773

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:0 Weeks to 30 Weeks
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Ashley Fischer, MD
CONTACT
309-624-8977
Ashley.M.Fischer2@osfhealthcare.org

Principal Investigator

Ashley Fischer, MD
PRINCIPAL_INVESTIGATOR
University of Illinois College of Medicine at Peoria

Study Locations (Sites)

University of Illinois College of Medicince
Peoria, Illinois, 61604
United States

Collaborators and Investigators

Sponsor: University of Illinois College of Medicine at Peoria

  • Ashley Fischer, MD, PRINCIPAL_INVESTIGATOR, University of Illinois College of Medicine at Peoria

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-09-22
Study Completion Date2025-09-22

Study Record Updates

Study Start Date2022-09-22
Study Completion Date2025-09-22

Terms related to this study

Additional Relevant MeSH Terms

  • Ventilator Lung; Newborn