RECRUITING

Leveraging Technology to Improve Medication Adherence in Youth With Kidney or Liver Transplant

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Can the investigators create an effective way to improve adherence to immunosuppressant medication and reduce rejection, graft loss, and death in adolescents and young adults who have undergone kidney or liver transplantation? The investigators' mobile technology intervention uses real-time electronic pillbox-assessed dose timing and text message prompts to address antirejection medication nonadherence when nonadherence is detected.

Official Title

Leveraging Technology to Improve Medication Adherence in Adolescent and Young Adult Kidney or Liver Transplant Recipients: A Micro-Randomized Trial

Quick Facts

Study Start:2024-03-19
Study Completion:2026-06
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05613010

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:13 Years to 25 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT
Inclusion CriteriaExclusion Criteria
  1. * Adolescents and young adults (13-25 years old) who underwent kidney or liver transplantation at least 6 months prior to enrollment
  2. * Currently prescribed tacrolimus or sirolimus.
  1. * Currently receiving dialysis
  2. * Hospitalized for duration of study
  3. * Significant developmental or cognitive delay
  4. * No access to a mobile device that supports text messaging
  5. * Decline to use electronic pill box to monitor daily medication adherence
  6. * Non-English speaking
  7. * If a participant meets inclusion criteria, enrolls in the study, and experiences graft failure potentially leading to dialysis in the case of kidney transplant recipients, the participant will be given the option to continue in the study if they remain on tacrolimus or sirolimus.

Contacts and Locations

Study Contact

Cyd Eaton, PhD
CONTACT
667-306-6201
ceaton4@jhmi.edu

Principal Investigator

Cyd Eaton, PhD
PRINCIPAL_INVESTIGATOR
Johns Hopkins University

Study Locations (Sites)

Johns Hopkins
Baltimore, Maryland, 21287
United States

Collaborators and Investigators

Sponsor: Johns Hopkins University

  • Cyd Eaton, PhD, PRINCIPAL_INVESTIGATOR, Johns Hopkins University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-03-19
Study Completion Date2026-06

Study Record Updates

Study Start Date2024-03-19
Study Completion Date2026-06

Terms related to this study

Keywords Provided by Researchers

  • kidney transplant
  • liver transplant
  • medication adherence
  • medication nonadherence
  • compliance
  • mobile health
  • mobile phone
  • technology

Additional Relevant MeSH Terms

  • Transplant;Failure,Kidney
  • Transplant; Failure, Liver
  • Adherence, Medication
  • Adherence, Patient
  • Adherence, Treatment