ACTIVE_NOT_RECRUITING

Alzheimer's Disease Neuroimaging Initiative 4

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Conditions

Mild Cognitive ImpairmentAlzheimer DiseaseDementiaamyloidplaquesneuroimagingbiomarkerscognition disorderearly detectionpre-dementiaAlzheimer's diseasetauobservational

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Since its launch in 2004, the overarching aim of the Alzheimer's Disease Neuroimaging Initiative (ADNI) Study has been to validate biomarkers for Alzheimer's disease (AD) clinical trials. ADNI4 continues the previously funded ADNI1, ADNI-GO, ADNI2, and ADNI3 studies that have combined public/private collaborations between academia and industry to determine the relationships between the clinical, cognitive, imaging, genetic and biochemical biomarker characteristics of the entire spectrum of AD.

Official Title

Alzheimer's Disease Neuroimaging Initiative 4 (ADNI4)

Quick Facts

Study Start:2023-06-09
Study Completion:2027-07-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:ACTIVE_NOT_RECRUITING

Study ID

NCT05617014

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:55 Years to 90 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Principal Investigator

Michael Weiner, MD
STUDY_DIRECTOR
University of California, San Francisco
Paul Aisen, MD
PRINCIPAL_INVESTIGATOR
USC Alzheimer's Therapeutic Research Institute (ATRI)
Ronald Petersen, MD, PHD
PRINCIPAL_INVESTIGATOR
Mayo Clinic

Study Locations (Sites)

University of Alabama at Birmingham
Birmingham, Alabama, 35233
United States
Banner Alzheimer's Institute
Phoenix, Arizona, 85006
United States
Barrow Neurological Institute
Phoenix, Arizona, 85013
United States
Banner Sun Health Research Institute
Sun City, Arizona, 85351
United States
University of California, Irvine
Irvine, California, 92697
United States
University of California, San Diego
La Jolla, California, 92037
United States
University of California, Los Angeles
Los Angeles, California, 90024
United States
University of Southern California
Los Angeles, California, 90033
United States
Stanford University
Palo Alto, California, 94304
United States
University of California, San Francisco
San Francisco, California, 94158
United States
University of California, Davis
Walnut Creek, California, 94598
United States
Yale University
New Haven, Connecticut, 06520
United States
Georgetown University
Washington, District of Columbia, 200072145
United States
Howard University
Washington, District of Columbia, 20060
United States
Mayo Clinic, Jacksonville
Jacksonville, Florida, 32224
United States
Wien Center
Miami Beach, Florida, 33140
United States
Gonzalez MD & Aswad MD Health Services
Miami, Florida, 33135
United States
Charter Research
Orlando, Florida, 32803
United States
University of South Florida Health Byrd Alzheimer's Institute
Tampa, Florida, 336134808
United States
Emory University
Atlanta, Georgia, 30322
United States
Northwestern University
Chicago, Illinois, 60611
United States
Rush University Memory Clinic
Chicago, Illinois, 60612
United States
Indiana University
Indianapolis, Indiana, 46202
United States
University of Iowa
Iowa City, Iowa, 52242
United States
University of Kansas
Fairway, Kansas, 66205
United States
University of Kentucky
Lexington, Kentucky, 40536
United States
Johns Hopkins University
Baltimore, Maryland, 21224
United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02115
United States
Boston University
Boston, Massachusetts, 02118
United States
Brigham and Women's Hospital
Boston, Massachusetts, 21155
United States
University of Michigan, Ann Arbor
Ann Arbor, Michigan, 48109
United States
Mayo Clinic Alzheimer's Disease Research Center
Rochester, Minnesota, 55901
United States
Washington University, St Louis
Saint Louis, Missouri, 63108
United States
Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas
Las Vegas, Nevada, 89101
United States
Albany Medical College
Albany, New York, 12208
United States
Dent Neurological Institute
Buffalo, New York, 142261727
United States
Mount Sinai School of Medicine
New York, New York, 100296552
United States
Nathan Kline Institute for Psychiatric Research
Orangeburg, New York, 109621159
United States
University of Rochester
Rochester, New York, 14620
United States
Duke University Medical Center
Durham, North Carolina, 27705
United States
Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157
United States
Case Western Reserve University
Cleveland, Ohio, 44122
United States
Ohio State University
Columbus, Ohio, 43210
United States
Central States Research
Tulsa, Oklahoma, 74136
United States
Oregon Health & Science University
Portland, Oregon, 97239
United States
University of Pennsylvania
Philadelphia, Pennsylvania, 19104
United States
University of Pittsburgh
Pittsburgh, Pennsylvania, 15213
United States
Rhode Island Hospital
Providence, Rhode Island, 02903
United States
Butler Hospital, Memory and Aging Program
Providence, Rhode Island, 02906
United States
Ralph H. Johnson VA Health Care System
Charleston, South Carolina, 29401
United States
Vanderbilt University Medical Center Center for Cognitive Medicine
Nashville, Tennessee, 37212
United States
University of Texas Southwestern Medical Center
Dallas, Texas, 75390
United States
Baylor College of Medicine
Houston, Texas, 77030
United States
University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78229
United States
University of Wisconsin
Madison, Wisconsin, 53792
United States

Collaborators and Investigators

Sponsor: University of Southern California

  • Michael Weiner, MD, STUDY_DIRECTOR, University of California, San Francisco
  • Paul Aisen, MD, PRINCIPAL_INVESTIGATOR, USC Alzheimer's Therapeutic Research Institute (ATRI)
  • Ronald Petersen, MD, PHD, PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-06-09
Study Completion Date2027-07-31

Study Record Updates

Study Start Date2023-06-09
Study Completion Date2027-07-31

Terms related to this study

Keywords Provided by Researchers

  • amyloid
  • plaques
  • neuroimaging
  • biomarkers
  • cognition disorder
  • early detection
  • pre-dementia
  • dementia
  • Alzheimer's disease
  • tau
  • observational

Additional Relevant MeSH Terms

  • Mild Cognitive Impairment
  • Alzheimer Disease
  • Dementia