A Clinical Trial of Tolcapone in Obsessive Compulsive Disorder

Eligibility Criteria

• 1. Men and women age 18-65 years
• 2. Primary diagnosis of OCD
• 3. YBOCS score of at least 21 at baseline (moderate or higher severity)
• 4. Ability to understand and sign the consent form
• 1. Unstable medical illness based on history or clinically significant abnormalities on baseline physical examination
• 2. Current pregnancy or lactation, or inadequate contraception in women of childbearing potential
• 3. Subjects considered an immediate suicide risk based on the Columbia Suicide Severity rating Scale (C-SSRS) (www.cssrs.columbia.edu/docs)
• 4. History of psychosis or bipolar disorder based on DSM-5 criteria
• 5. Alcohol/substance use disorder and/or illegal substance use based on urine toxicology
• 6. Initiation of psychological interventions within 3 months of screening (those who are continuing with CBT will be included)
• 7. Use of any new psychotropic medication within 3 months of study entry (stable doses of psychotropics will be allowed)
• 8. Major cognitive impairment that interferes with the capacity to understand and self-administer medication or provide written informed consent
• 9. Abnormal liver function tests at baseline
• 10. MADRS \>30 at baseline