Investigating the Effects of Cannabidiol on Social Anxiety Disorder

Eligibility Criteria

• * Ability and willingness to provide written informed consent.
• * Sufficiently fluent in English to participate in the trial.
• * Between 18-55 years of age (inclusive).
• * Right-hand dominant.
• * Current medications are stable for past 30 days (no changes to dose or frequency).
• * Negative result on pregnancy test (if female).
• * Negative result on urine drug screening.
• * Liebowitz Social Anxiety Scale (LSAS ≥ 60).
• * History of bipolar disorder, schizophrenia, psychosis, delusional disorders.
• * History of eating disorder within past 6 months.
• * History of any traumatic brain injury.
• * Currently diagnosed with diabetes mellitus.
• * Presence of severe medical illness that would prevent completion of study procedures.
• * Presence of significant neurological illness or cognitive dysfunction (e.g.; seizures, dementia).
• * History of substance use disorder within past 6 months (other than nicotine and caffeine).
• * Use of any cannabis-containing products in past 30 days (CBD or THC).
• * Use of benzodiazepines in past 2 weeks.
• * Use of alpha- or beta-blockers in past week.
• * History of claustrophobia.
• * Contraindications for MRI (e.g.; shrapnel).
• * Presence of any other medical condition that, in the investigator's opinion, may interfere with the study procedures.
• * Use of concomitant medication that has a strong interaction with CBD.
• * History of liver disease.
• * History of hypersensitivity to cannabinoids.
• * History of hypersensitivity to sesame seed oil.
• * Currently breastfeeding (if female).