RECRUITING

Does Joint Lavage Reduce Intraarticular Inflammation in High-energy Tibial Pilon Fractures?

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

High-energy tibial pilon fractures have historically been associated with poor outcomes largely due to the elevated risk of severe post-traumatic arthritis. Intraarticular fractures result in a pro-inflammatory hemarthrosis that may further exacerbate the chondral damage that was sustained due to the original injury. This project will study the effect of joint lavage on the concentration of inflammatory cytokines in the ankle following a high-energy tibial pilon fracture and the resultant effect on short-term patient outcomes.

Official Title

Does Joint Lavage Reduce Intraarticular Inflammation in High-energy Tibial Pilon Fractures?

Quick Facts

Study Start:2023-01-15
Study Completion:2025-07
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05652881

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Male or female age 18 years or older
  2. * Present with an axially unstable tibial pilon fracture requiring temporary external fixation followed by delayed definitive internal fixation
  3. * Able to give informed consent
  1. * Open fractures
  2. * Delayed presentation greater than 72 hours post-injury
  3. * Associated talar body fracture
  4. * Presentation after initial ex-fix placement
  5. * Unreconstructable or unsalvageable joint
  6. * Preexisting ankle arthritis
  7. * Previous ankle surgery
  8. * Contralateral ankle injury
  9. * Age less than 18 years
  10. * Pregnant women
  11. * Individuals who are incarcerated

Contacts and Locations

Study Contact

Benjamin M Wheatley, MD
CONTACT
619-532-5101
benjamin.m.wheatley.mil@mail.mil

Study Locations (Sites)

Brooke Army Medical Center
Fort Sam Houston, Texas, 78234
United States

Collaborators and Investigators

Sponsor: United States Naval Medical Center, San Diego

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-01-15
Study Completion Date2025-07

Study Record Updates

Study Start Date2023-01-15
Study Completion Date2025-07

Terms related to this study

Additional Relevant MeSH Terms

  • Post-traumatic; Arthrosis
  • Tibial Fractures
  • Post-Traumatic Osteoarthritis of Ankle