RECRUITING

Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity

Conditions

Mild Cognitive Impairment Chronic Kidney Diseases chronic kidney disease exercise Lifestyle behavior home-based exercise

Quick Navigation

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to see if 6 months of home-based walking will improve memory, and brain structure and function, compared to health education in older adults that have chronic kidney disease and mild cognitive impairment.

Official Title

Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity

Quick Facts

Study Start:2024-06-18

Study Completion:2026-12-01

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT05655325

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:55 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* • Diagnosed stage 3-4 chronic kidney disease (CKD, estimated glomerular filtration rate (eGFR) \<60 to 20 ml/min); * \>55 yrs of age * Mild cognitive impairment (18-26 on the MOCA) * ability to undergo an MR * no history of major head trauma (No head trauma/concussion with loss of consciousness) * Speaks, reads, writes English	* • Diagnosed Dementia or a Clinical Dementia Rating Scale score of \<2, or a MOCA of \<18 * Participating in a supervised exercise program with intent to increase fitness levels 3 days/week, * Requires assistive ambulation * Limited exercise capacity due to claudication; unstable angina, severe arthritis, extreme dyspnea on exertion, unstable coronary artery disease * Class III-IV heart failure * History of uncontrolled sustained arrhythmias, severe/symptomatic aortic or mitral stenosis, hypertrophic obstructive cardiomyopathy, severe pulmonary hypertension, active myocarditis/pericarditis, thrombophlebitis, and recent systemic/pulmonary embolus * Resting systolic BP \>200 mmHg or resting diastolic BP \>110 mmHg * Any unforeseen illness or disability that would preclude cognitive testing or exercise training * One or more contraindication for MRI; cardiac pacemaker, aneurysm clip, cochlear implants, shrapnel, history of metal fragments in eyes, neurostimulators, diagnosed claustrophobia (MRI only) * Any self-reported major psychiatric disorders requiring medical therapy (e.g. schizophrenia, bipolar disorder). * Self-reported new diagnosis of clinical depression within 3 months of enrollment or unstable clinical depression requiring medication adjustment within 3 months of enrollment

Inclusion Criteria

Exclusion Criteria

* • Diagnosed stage 3-4 chronic kidney disease (CKD, estimated glomerular filtration rate (eGFR) \<60 to 20 ml/min);
* \>55 yrs of age
* Mild cognitive impairment (18-26 on the MOCA)
* ability to undergo an MR
* no history of major head trauma (No head trauma/concussion with loss of consciousness)
* Speaks, reads, writes English

* • Diagnosed Dementia or a Clinical Dementia Rating Scale score of \<2, or a MOCA of \<18
* Participating in a supervised exercise program with intent to increase fitness levels 3 days/week,
* Requires assistive ambulation
* Limited exercise capacity due to claudication; unstable angina, severe arthritis, extreme dyspnea on exertion, unstable coronary artery disease
* Class III-IV heart failure
* History of uncontrolled sustained arrhythmias, severe/symptomatic aortic or mitral stenosis, hypertrophic obstructive cardiomyopathy, severe pulmonary hypertension, active myocarditis/pericarditis, thrombophlebitis, and recent systemic/pulmonary embolus
* Resting systolic BP \>200 mmHg or resting diastolic BP \>110 mmHg
* Any unforeseen illness or disability that would preclude cognitive testing or exercise training
* One or more contraindication for MRI; cardiac pacemaker, aneurysm clip, cochlear implants, shrapnel, history of metal fragments in eyes, neurostimulators, diagnosed claustrophobia (MRI only)
* Any self-reported major psychiatric disorders requiring medical therapy (e.g. schizophrenia, bipolar disorder).
* Self-reported new diagnosis of clinical depression within 3 months of enrollment or unstable clinical depression requiring medication adjustment within 3 months of enrollment

Contacts and Locations

Study Contact

Ulf G Bronas, PhD

CONTACT

212-305-0750

ub2154@cumc.columbia.edu

Principal Investigator

Ulf G Bronas, PhD

PRINCIPAL_INVESTIGATOR

Columbia University

Study Locations (Sites)

Columbia University

New York, New York, 10023

United States

Collaborators and Investigators

Sponsor: Columbia University

Ulf G Bronas, PhD, PRINCIPAL_INVESTIGATOR, Columbia University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-06-18

Study Completion Date2026-12-01

Study Record Updates

Study Start Date2024-06-18

Study Completion Date2026-12-01

Terms related to this study

Keywords Provided by Researchers

mild cognitive impairment
chronic kidney disease
exercise
Lifestyle behavior
home-based exercise

Additional Relevant MeSH Terms

Mild Cognitive Impairment
Chronic Kidney Diseases