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TMS Related Biomarker Assessments

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Conditions

Schizophrenia SchizoaffectiveSchizophreniaTranscranial magnetic stimulation

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Patients with schizophrenia spectrum disorder (SSD) will be exposed to active and sham repetitive transcranial magnetic stimulation (rTMS) in separate sessions. SSD-related biomarkers will be assessed before and after the rTMS administration.

Official Title

TMS Related Biomarker Assessments

Quick Facts

Study Start:2023-01-07
Study Completion:2025-02-14
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT05660018

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Male and Female between ages 18-65
  2. * Ability to give written informed consent (age 18 or above)
  3. * Diagnosed with schizophrenia-spectrum disorder and Evaluation to Sign Consent (ESC) above10.
  1. * Any history of seizures.
  2. * Significant alcohol or other drug use (substance dependence within 6 months or substance abuse within 1 month) other than nicotine or marijuana dependence.
  3. * Any major medical illnesses that may affect normal brain functioning. Examples of these conditions include, but not limited to, stroke, CNS infection or tumor, other significant brain neurological conditions.
  4. * Taking \> 400 mg clozapine/day
  5. * Failed TMS screening questionnaire
  6. * Cardiac pacemakers, implanted medication pumps, intracardiac lines, or acute, unstable cardiac disease, with intracranial implants (e.g. aneurysm clips, shunts, stimulators, cochlear implants, or electrodes) or any other metal object within or near the head, excluding the mouth, that cannot be safely removed.
  7. * History of head injury with loss of consciousness over 10 minutes; history of brain surgery
  8. * Can not refrain from using alcohol and/or marijuana 24 hours or more \& cigarette smoking half and hour or more prior to experiments.
  9. * Woman who is pregnant (child-bearing potential but not on contraceptive and missing menstrual period; or by self report; or by positive pregnancy test) or has had unprotected sexual intercourse without birth control in the last 4 weeks.

Contacts and Locations

Principal Investigator

Xiaoming Du, PhD
PRINCIPAL_INVESTIGATOR
University of Maryland, Baltimore

Study Locations (Sites)

University of Maryland, Baltimore
Baltimore, Maryland, 21228
United States

Collaborators and Investigators

Sponsor: University of Maryland, Baltimore

  • Xiaoming Du, PhD, PRINCIPAL_INVESTIGATOR, University of Maryland, Baltimore

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-01-07
Study Completion Date2025-02-14

Study Record Updates

Study Start Date2023-01-07
Study Completion Date2025-02-14

Terms related to this study

Keywords Provided by Researchers

  • schizophrenia
  • Transcranial magnetic stimulation

Additional Relevant MeSH Terms

  • Schizophrenia Schizoaffective
  • Schizophrenia