RECRUITING

mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma

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Conditions

Advanced Esophageal AdenocarcinomaAdvanced Gastric AdenocarcinomaAdvanced Gastroesophageal Junction AdenocarcinomaClinical Stage III Esophageal Adenocarcinoma AJCC v8Clinical Stage III Gastric Cancer AJCC v8Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8Clinical Stage IV Esophageal Adenocarcinoma AJCC v8Clinical Stage IV Gastric Cancer AJCC v8Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8Metastatic Esophageal AdenocarcinomaMetastatic Gastric AdenocarcinomaMetastatic Gastroesophageal Junction AdenocarcinomaUnresectable Esophageal AdenocarcinomaUnresectable Gastric AdenocarcinomaUnresectable Gastroesophageal Junction Adenocarcinoma

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This phase III trial compares the effect of modified fluorouracil, leucovorin calcium, oxaliplatin, and irinotecan (mFOLFIRINOX) to modified fluorouracil, leucovorin calcium, and oxaliplatin (mFOLFOX) for the treatment of advanced, unresectable, or metastatic HER2 negative esophageal, gastroesophageal junction, and gastric adenocarcinoma. The usual approach for patients is treatment with FOLFOX chemotherapy. Chemotherapy drugs work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Fluorouracil stops cells from making DNA and it may kill tumor cells. Leucovorin is used with fluorouracil to enhance the effects of the drug. Oxaliplatin works by killing, stopping, or slowing the growth of tumor cells. Some patients also receive an immunotherapy drug, nivolumab, in addition to FOLFOX chemotherapy. Immunotherapy may induce changes in body's immune system and may interfere with the ability of tumor cells to grow and spread. Irinotecan blocks certain enzymes needed for cell division and DNA repair, and it may kill tumor cells. Adding irinotecan to the FOLFOX regimen could shrink the cancer and extend the life of patients with advanced gastroesophageal cancers.

Official Title

Randomized Phase III Trial of mFOLFIRINOX vs. FOLFOX With Nivolumab for First-Line Treatment of Metastatic HER2- Gastroesophageal Adenocarcinoma

Quick Facts

Study Start:2023-01-23
Study Completion:2028-11-08
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05677490

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Histologic documentation: HER2 negative adenocarcinoma as defined by American Society of Clinical Oncology (ASCO) College of American Pathologists (CAP) guidelines (Bartley et al., Journal of Clinical Oncology \[JCO\] 2017) with known PD-L1 CPS (Any CPS is allowed, but should be known prior to registration)
  2. * Stage: unresectable or metastatic
  3. * Tumor site: esophagus, gastroesophageal junction, or stomach
  4. * Measurable disease or non-measurable but evaluable disease as defined by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1
  5. * No prior treatment for unresectable or metastatic disease
  6. * Prior neoadjuvant or adjuvant cytotoxic chemotherapy or adjuvant immunotherapy is allowed as long as it was completed at least 1 year prior to registration
  7. * Age \>= 18 years
  8. * Eastern Cooperative Oncology Group (ECOG) Performance Status 0 or 1
  9. * Absolute neutrophil count (ANC) \>= 1,500/mm\^3
  10. * Platelet count \>= 100,000/mm\^3
  11. * Creatinine =\< 1.5 x upper limit of normal (ULN) OR calculated (calc.) creatinine clearance \>= 30 mL/min
  12. * Total bilirubin =\< 1.5 x ULN
  13. * Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =\< 3 x ULN (in patients with liver metastasis: =\< 5 x ULN if clearly attributable to liver metastases)
  14. * Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial
  15. * Patients positive for human immunodeficiency virus (HIV) are eligible only if they meet all of the following:
  16. * On effective anti-retroviral therapy
  17. * Undetectable HIV viral load by standard clinical assay =\< 6 months of registration
  18. * Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better
  19. * Patients who will receive nivolumab in addition to chemotherapy must not have any contraindications to immune checkpoint inhibitors
  20. * Patients must not have active autoimmune disease that has required systemic treatment within 6 months prior to registration. Patients are permitted to receive immunotherapy if they have vitiligo, type I diabetes, residual hypothyroidism due to autoimmune condition only requiring hormone replacement, psoriasis not requiring systemic treatment, or conditions not expected to recur in the absence of an external trigger (precipitating event)
  21. * Patients must not have a condition requiring systemic treatment with either corticosteroids (\>10mg/day prednisone equivalents) or other immunosuppressive medications within 14 days prior to registration. Inhaled or topical steroids and adrenal replacement doses (=\< 10mg/day prednisone equivalent) are permitted
  22. * Patients must not have a history of noninfectious pneumonitis requiring steroids
  23. * Patients with prior immune mediated adverse events related to immunotherapy that resulted in permanent treatment discontinuation with these agents are ineligible
  24. * This study includes the use of the mandatory patient completed measure, PRO-CTCAE. For this study the PRO-CTCAE is available in English, Spanish, Korean, Chinese (Simplified), and Russian, hence patients must be able to speak, understand and read in these languages. Ad-hoc translation of patient-reported measures is not permitted
  1. * Not pregnant and not nursing, because this study involves an agent that has known genotoxic, mutagenic and teratogenic effects
  2. * No known Gilbert's syndrome or known homozygosity for UGAT1A1\*28 polymorphism
  3. * No baseline grade \>= 2 peripheral neuropathy, neurosensory toxicity, or neuromotor toxicity per CTCAE version (v) 5.0 regardless of causality
  4. * No medical condition such as uncontrolled infection or uncontrolled diabetes mellitus which, in the opinion of the treating physician, would make this protocol unreasonably hazardous for the patient
  5. * No untreated, symptomatic brain metastasis. Patients with treated brain metastases are eligible if the following criteria are met: 1) follow-up brain imaging done at least in 4 weeks after central nervous system (CNS)-directed therapy shows no evidence of progression and 2) the patient no longer requires steroids, or is on a stable steroid dose for more than four weeks
  6. * No allogeneic tissue/organ transplant

Contacts and Locations

Study Contact

Aishwarya Vijendran
CONTACT
773-834-9613
aishwaryav@bsd.uchicago.edu

Study Locations (Sites)

University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, 35233
United States
Anchorage Associates in Radiation Medicine
Anchorage, Alaska, 98508
United States
Anchorage Radiation Therapy Center
Anchorage, Alaska, 99504
United States
Alaska Breast Care and Surgery LLC
Anchorage, Alaska, 99508
United States
Alaska Oncology and Hematology LLC
Anchorage, Alaska, 99508
United States
Alaska Women's Cancer Care
Anchorage, Alaska, 99508
United States
Anchorage Oncology Centre
Anchorage, Alaska, 99508
United States
Katmai Oncology Group
Anchorage, Alaska, 99508
United States
Providence Alaska Medical Center
Anchorage, Alaska, 99508
United States
Fairbanks Memorial Hospital
Fairbanks, Alaska, 99701
United States
Kingman Regional Medical Center
Kingman, Arizona, 86401
United States
Cancer Center at Saint Joseph's
Phoenix, Arizona, 85004
United States
Mercy Hospital Fort Smith
Fort Smith, Arkansas, 72903
United States
CARTI Cancer Center
Little Rock, Arkansas, 72205
United States
Kaiser Permanente-Deer Valley Medical Center
Antioch, California, 94531
United States
Mission Hope Medical Oncology - Arroyo Grande
Arroyo Grande, California, 93420
United States
PCR Oncology
Arroyo Grande, California, 93420
United States
Sutter Auburn Faith Hospital
Auburn, California, 95602
United States
Sutter Cancer Centers Radiation Oncology Services-Auburn
Auburn, California, 95603
United States
Alta Bates Summit Medical Center-Herrick Campus
Berkeley, California, 94704
United States
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank, California, 91505
United States
Mills-Peninsula Medical Center
Burlingame, California, 94010
United States
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Cameron Park, California, 95682
United States
Mercy Cancer Center - Carmichael
Carmichael, California, 95608
United States
Mercy San Juan Medical Center
Carmichael, California, 95608
United States
Eden Hospital Medical Center
Castro Valley, California, 94546
United States
UC Irvine Health Cancer Center-Newport
Costa Mesa, California, 92627
United States
Sutter Davis Hospital
Davis, California, 95616
United States
Kaiser Permanente Dublin
Dublin, California, 94568
United States
Mercy Cancer Center - Elk Grove
Elk Grove, California, 95758
United States
Kaiser Permanente-Fremont
Fremont, California, 94538
United States
Palo Alto Medical Foundation-Fremont
Fremont, California, 94538
United States
Fresno Cancer Center
Fresno, California, 93720
United States
Kaiser Permanente-Fresno
Fresno, California, 93720
United States
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, California, 92612
United States
Keck Medicine of USC Koreatown
Los Angeles, California, 90020
United States
Los Angeles General Medical Center
Los Angeles, California, 90033
United States
USC / Norris Comprehensive Cancer Center
Los Angeles, California, 90033
United States
Contra Costa Regional Medical Center
Martinez, California, 94553-3156
United States
Mercy Cancer Center
Merced, California, 95340
United States
Memorial Medical Center
Modesto, California, 95355
United States
Kaiser Permanente-Modesto
Modesto, California, 95356
United States
Palo Alto Medical Foundation-Camino Division
Mountain View, California, 94040
United States
Palo Alto Medical Foundation-Gynecologic Oncology
Mountain View, California, 94040
United States
Providence Queen of The Valley
Napa, California, 94558
United States
USC Norris Oncology/Hematology-Newport Beach
Newport Beach, California, 92663
United States
Sutter Cancer Research Consortium
Novato, California, 94945
United States
Kaiser Permanente Oakland-Broadway
Oakland, California, 94611
United States
Kaiser Permanente-Oakland
Oakland, California, 94611
United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California, 92868
United States
Palo Alto Medical Foundation Health Care
Palo Alto, California, 94301
United States
Kaiser Permanente-Rancho Cordova Cancer Center
Rancho Cordova, California, 95670
United States
Eisenhower Medical Center
Rancho Mirage, California, 92270
United States
Kaiser Permanente- Marshall Medical Offices
Redwood City, California, 94063
United States
Kaiser Permanente-Richmond
Richmond, California, 94801
United States
Mercy Cancer Center - Rocklin
Rocklin, California, 95765
United States
Rohnert Park Cancer Center
Rohnert Park, California, 94928
United States
Kaiser Permanente-Roseville
Roseville, California, 95661
United States
Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville, California, 95661
United States
Sutter Roseville Medical Center
Roseville, California, 95661
United States
The Permanente Medical Group-Roseville Radiation Oncology
Roseville, California, 95678
United States
Kaiser Permanente Downtown Commons
Sacramento, California, 95814
United States
Mercy Cancer Center - Sacramento
Sacramento, California, 95816
United States
Sutter Medical Center Sacramento
Sacramento, California, 95816
United States
Kaiser Permanente-South Sacramento
Sacramento, California, 95823
United States
South Sacramento Cancer Center
Sacramento, California, 95823
United States
California Pacific Medical Center-Pacific Campus
San Francisco, California, 94115
United States
Kaiser Permanente-San Francisco
San Francisco, California, 94115
United States
Kaiser Permanente-Santa Teresa-San Jose
San Jose, California, 95119
United States
Kaiser Permanente San Leandro
San Leandro, California, 94577
United States
Pacific Central Coast Health Center-San Luis Obispo
San Luis Obispo, California, 93401
United States
Mills Health Center
San Mateo, California, 94401
United States
Kaiser San Rafael-Gallinas
San Rafael, California, 94903
United States
Ridley-Tree Cancer Center
Santa Barbara, California, 93105
United States
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California, 95051
United States
Palo Alto Medical Foundation-Santa Cruz
Santa Cruz, California, 95065
United States
Santa Cruz Radiation Oncology Medical Group
Santa Cruz, California, 95065
United States
Mission Hope Medical Oncology - Santa Maria
Santa Maria, California, 93444
United States
Kaiser Permanente-Santa Rosa
Santa Rosa, California, 95403
United States
Providence Medical Foundation - Santa Rosa
Santa Rosa, California, 95403
United States
Sutter Pacific Medical Foundation
Santa Rosa, California, 95403
United States
Providence Santa Rosa Memorial Hospital
Santa Rosa, California, 95405
United States
Kaiser Permanente Cancer Treatment Center
South San Francisco, California, 94080
United States
Kaiser Permanente-South San Francisco
South San Francisco, California, 94080
United States
Kaiser Permanente-Stockton
Stockton, California, 95210
United States
Palo Alto Medical Foundation-Sunnyvale
Sunnyvale, California, 94086
United States
Kaiser Permanente Medical Center-Vacaville
Vacaville, California, 95688
United States
Kaiser Permanente-Vallejo
Vallejo, California, 94589
United States
Sutter Solano Medical Center/Cancer Center
Vallejo, California, 94589
United States
Kaiser Permanente-Walnut Creek
Walnut Creek, California, 94596
United States
BASS Medical Group - Lennon
Walnut Creek, California, 94598
United States
Woodland Memorial Hospital
Woodland, California, 95695
United States
Rocky Mountain Cancer Centers-Aurora
Aurora, Colorado, 80012
United States
Boulder Community Foothills Hospital
Boulder, Colorado, 80303
United States
Rocky Mountain Cancer Centers-Boulder
Boulder, Colorado, 80304
United States
Intermountain Health Platte Valley Hospital
Brighton, Colorado, 80601
United States
Rocky Mountain Cancer Centers - Centennial
Centennial, Colorado, 80112
United States
Penrose-Saint Francis Healthcare
Colorado Springs, Colorado, 80907
United States
Rocky Mountain Cancer Centers-Penrose
Colorado Springs, Colorado, 80907
United States
UCHealth Memorial Hospital Central
Colorado Springs, Colorado, 80909
United States
Memorial Hospital North
Colorado Springs, Colorado, 80920
United States
Saint Francis Cancer Center
Colorado Springs, Colorado, 80923
United States
National Jewish Health-Main Campus
Denver, Colorado, 80206
United States
The Women's Imaging Center
Denver, Colorado, 80209
United States
Porter Adventist Hospital
Denver, Colorado, 80210
United States
Colorado Blood Cancer Institute
Denver, Colorado, 80218
United States
Presbyterian - Saint Lukes Medical Center - Health One
Denver, Colorado, 80218
United States
Rocky Mountain Cancer Centers-Midtown
Denver, Colorado, 80218
United States
SCL Health Saint Joseph Hospital
Denver, Colorado, 80218
United States
Rocky Mountain Cancer Centers-Rose
Denver, Colorado, 80220
United States
Rose Medical Center
Denver, Colorado, 80220
United States
Mercy Medical Center
Durango, Colorado, 81301
United States
Southwest Oncology PC
Durango, Colorado, 81301
United States
Mountain Blue Cancer Care Center - Swedish
Englewood, Colorado, 80113
United States
Rocky Mountain Cancer Centers - Swedish
Englewood, Colorado, 80113
United States
Swedish Medical Center
Englewood, Colorado, 80113
United States
The Melanoma and Skin Cancer Institute
Englewood, Colorado, 80113
United States
Poudre Valley Hospital
Fort Collins, Colorado, 80524
United States
Cancer Care and Hematology-Fort Collins
Fort Collins, Colorado, 80528
United States
Lutheran Hospital - Cancer Centers of Colorado
Golden, Colorado, 80401
United States
National Jewish Health-Western Hematology Oncology
Golden, Colorado, 80401
United States
Saint Mary's Hospital and Regional Medical Center
Grand Junction, Colorado, 81501
United States
UCHealth Greeley Hospital
Greeley, Colorado, 80631
United States
Good Samaritan Hospital - Cancer Centers of Colorado
Lafayette, Colorado, 80026
United States
Rocky Mountain Cancer Centers-Lakewood
Lakewood, Colorado, 80228
United States
Saint Anthony Hospital
Lakewood, Colorado, 80228
United States
Rocky Mountain Cancer Centers-Littleton
Littleton, Colorado, 80120
United States
Littleton Adventist Hospital
Littleton, Colorado, 80122
United States
Rocky Mountain Cancer Centers-Sky Ridge
Lone Tree, Colorado, 80124
United States
Longmont United Hospital
Longmont, Colorado, 80501
United States
Rocky Mountain Cancer Centers-Longmont
Longmont, Colorado, 80501
United States
Medical Center of the Rockies
Loveland, Colorado, 80538
United States
Parker Adventist Hospital
Parker, Colorado, 80138
United States
Saint Mary Corwin Medical Center
Pueblo, Colorado, 81004
United States
National Jewish Health-Northern Hematology Oncology
Thornton, Colorado, 80260
United States
Rocky Mountain Cancer Centers-Thornton
Thornton, Colorado, 80260
United States
Intermountain Health Lutheran Hospital
Wheat Ridge, Colorado, 80401
United States
Hartford HealthCare - Avon
Avon, Connecticut, 06001
United States
Hartford Hospital
Hartford, Connecticut, 06102
United States
Hartford HealthCare - Manchester
Manchester, Connecticut, 06042
United States
Midstate Medical Center
Meriden, Connecticut, 06451
United States
The Hospital of Central Connecticut
New Britain, Connecticut, 06050
United States
Beebe Medical Center
Lewes, Delaware, 19958
United States
Beebe South Coastal Health Campus
Millville, Delaware, 19967
United States
Delaware Clinical and Laboratory Physicians PA
Newark, Delaware, 19713
United States
Helen F Graham Cancer Center
Newark, Delaware, 19713
United States
Medical Oncology Hematology Consultants PA
Newark, Delaware, 19713
United States
Christiana Care Health System-Christiana Hospital
Newark, Delaware, 19718
United States
Beebe Health Campus
Rehoboth Beach, Delaware, 19971
United States
Christiana Care Health System-Wilmington Hospital
Wilmington, Delaware, 19801
United States
MedStar Georgetown University Hospital
Washington, District of Columbia, 20007
United States
Mount Sinai Comprehensive Cancer Center at Aventura
Aventura, Florida, 33180
United States
Holy Cross Hospital
Fort Lauderdale, Florida, 33308
United States
Regional Cancer Center-Lee Memorial Health System
Fort Myers, Florida, 33905
United States
University of Florida Health Science Center - Gainesville
Gainesville, Florida, 32610
United States
Mount Sinai Medical Center
Miami Beach, Florida, 33140
United States
Hawaii Cancer Care - Westridge
'Aiea, Hawaii, 96701
United States
Pali Momi Medical Center
'Aiea, Hawaii, 96701
United States
Queen's Cancer Center - Pearlridge
'Aiea, Hawaii, 96701
United States
The Cancer Center of Hawaii-Pali Momi
'Aiea, Hawaii, 96701
United States
The Queen's Medical Center - West Oahu
'Ewa Beach, Hawaii, 96706
United States
Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu, Hawaii, 96813
United States
Queen's Cancer Cenrer - POB I
Honolulu, Hawaii, 96813
United States
Queen's Medical Center
Honolulu, Hawaii, 96813
United States
Straub Clinic and Hospital
Honolulu, Hawaii, 96813
United States
University of Hawaii Cancer Center
Honolulu, Hawaii, 96813
United States
Hawaii Diagnostic Radiology Services LLC
Honolulu, Hawaii, 96817
United States
Kuakini Medical Center
Honolulu, Hawaii, 96817
United States
Queen's Cancer Center - Kuakini
Honolulu, Hawaii, 96817
United States
The Cancer Center of Hawaii-Liliha
Honolulu, Hawaii, 96817
United States
Kaiser Permanente Moanalua Medical Center
Honolulu, Hawaii, 96819
United States
Kapiolani Medical Center for Women and Children
Honolulu, Hawaii, 96826
United States
Straub Medical Center - Kahului Clinic
Kahului, Hawaii, 96732
United States
Castle Medical Center
Kailua, Hawaii, 96734
United States
Wilcox Memorial Hospital and Kauai Medical Clinic
Lihue, Hawaii, 96766
United States
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho, 83706
United States
Saint Luke's Cancer Institute - Boise
Boise, Idaho, 83712
United States
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho, 83605
United States
Kootenai Health - Coeur d'Alene
Coeur d'Alene, Idaho, 83814
United States
Walter Knox Memorial Hospital
Emmett, Idaho, 83617
United States
Saint Luke's Cancer Institute - Fruitland
Fruitland, Idaho, 83619
United States
Idaho Urologic Institute-Meridian
Meridian, Idaho, 83642
United States
Saint Luke's Cancer Institute - Meridian
Meridian, Idaho, 83642
United States
Saint Luke's Cancer Institute - Nampa
Nampa, Idaho, 83686
United States
Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho, 83687
United States
Kootenai Clinic Cancer Services - Post Falls
Post Falls, Idaho, 83854
United States
Kootenai Clinic Cancer Services - Sandpoint
Sandpoint, Idaho, 83864
United States
Saint Luke's Cancer Institute - Twin Falls
Twin Falls, Idaho, 83301
United States
Saint Anthony's Health
Alton, Illinois, 62002
United States
Rush - Copley Medical Center
Aurora, Illinois, 60504
United States
Advocate Outpatient Center - Aurora
Aurora, Illinois, 60506
United States
Advocate Good Shepherd Hospital
Barrington, Illinois, 60010
United States
Illinois CancerCare-Bloomington
Bloomington, Illinois, 61704
United States
Illinois CancerCare-Canton
Canton, Illinois, 61520
United States
Memorial Hospital of Carbondale
Carbondale, Illinois, 62902
United States
SIH Cancer Institute
Carterville, Illinois, 62918
United States
Illinois CancerCare-Carthage
Carthage, Illinois, 62321
United States
Centralia Oncology Clinic
Centralia, Illinois, 62801
United States
Saint Mary's Hospital
Centralia, Illinois, 62801
United States
Mount Sinai Hospital Medical Center
Chicago, Illinois, 60608
United States
John H Stroger Jr Hospital of Cook County
Chicago, Illinois, 60612
United States
University of Illinois
Chicago, Illinois, 60612
United States
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, 60637
United States
Advocate Illinois Masonic Medical Center
Chicago, Illinois, 60657
United States
AMG Crystal Lake - Oncology
Crystal Lake, Illinois, 60014
United States
Carle at The Riverfront
Danville, Illinois, 61832
United States
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois, 62526
United States
Decatur Memorial Hospital
Decatur, Illinois, 62526
United States
Illinois CancerCare-Dixon
Dixon, Illinois, 61021
United States
Advocate Good Samaritan Hospital
Downers Grove, Illinois, 60515
United States
Carle Physician Group-Effingham
Effingham, Illinois, 62401
United States
Crossroads Cancer Center
Effingham, Illinois, 62401
United States
Advocate Sherman Hospital
Elgin, Illinois, 60123
United States
Illinois CancerCare-Eureka
Eureka, Illinois, 61530
United States
Illinois CancerCare-Galesburg
Galesburg, Illinois, 61401
United States
Western Illinois Cancer Treatment Center
Galesburg, Illinois, 61401
United States
Ingalls Memorial Hospital
Harvey, Illinois, 60426
United States
Advocate South Suburban Hospital
Hazel Crest, Illinois, 60429
United States
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois, 61443
United States
AMG Libertyville - Oncology
Libertyville, Illinois, 60048
United States
Condell Memorial Hospital
Libertyville, Illinois, 60048
United States
Illinois CancerCare-Macomb
Macomb, Illinois, 61455
United States
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois, 61938
United States
Trinity Medical Center
Moline, Illinois, 61265
United States
Good Samaritan Regional Health Center
Mount Vernon, Illinois, 62864
United States
UC Comprehensive Cancer Center at Silver Cross
New Lenox, Illinois, 60451
United States
Carle Cancer Institute Normal
Normal, Illinois, 61761
United States
Cancer Care Center of O'Fallon
O'Fallon, Illinois, 62269
United States
HSHS Saint Elizabeth's Hospital
O'Fallon, Illinois, 62269
United States
Advocate Christ Medical Center
Oak Lawn, Illinois, 60453-2699
United States
University of Chicago Medicine-Orland Park
Orland Park, Illinois, 60462
United States
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois, 61350
United States
Advocate Lutheran General Hospital
Park Ridge, Illinois, 60068
United States
Illinois CancerCare-Pekin
Pekin, Illinois, 61554
United States
Illinois CancerCare-Peoria
Peoria, Illinois, 61615
United States
Methodist Medical Center of Illinois
Peoria, Illinois, 61636
United States
Illinois CancerCare-Peru
Peru, Illinois, 61354
United States
Valley Radiation Oncology
Peru, Illinois, 61354
United States
Illinois CancerCare-Princeton
Princeton, Illinois, 61356
United States
UW Health Carbone Cancer Center Rockford
Rockford, Illinois, 61114
United States
Southern Illinois University School of Medicine
Springfield, Illinois, 62702
United States
Springfield Clinic
Springfield, Illinois, 62702
United States
Memorial Medical Center
Springfield, Illinois, 62781
United States
Carle Cancer Center
Urbana, Illinois, 61801
United States
Illinois CancerCare - Washington
Washington, Illinois, 61571
United States
Rush-Copley Healthcare Center
Yorkville, Illinois, 60560
United States
Northwest Cancer Center - Main Campus
Crown Point, Indiana, 46307
United States
Northwest Oncology LLC
Dyer, Indiana, 46311
United States
Northwest Cancer Center - Hobart
Hobart, Indiana, 46342
United States
Saint Mary Medical Center
Hobart, Indiana, 46342
United States
Saint Catherine Hospital
Indianapolis, Indiana, 46312
United States
The Community Hospital
Munster, Indiana, 46321
United States
Women's Diagnostic Center - Munster
Munster, Indiana, 46321
United States
Reid Health
Richmond, Indiana, 47374
United States
Northwest Cancer Center - Valparaiso
Valparaiso, Indiana, 46383
United States
Mary Greeley Medical Center
Ames, Iowa, 50010
United States
McFarland Clinic - Ames
Ames, Iowa, 50010
United States
Mission Cancer and Blood - Ankeny
Ankeny, Iowa, 50023
United States
University of Iowa Healthcare Cancer Services Quad Cities
Bettendorf, Iowa, 52722
United States
McFarland Clinic - Boone
Boone, Iowa, 50036
United States
Mercy Hospital
Cedar Rapids, Iowa, 52403
United States
Oncology Associates at Mercy Medical Center
Cedar Rapids, Iowa, 52403
United States
Alegent Health Mercy Hospital
Council Bluffs, Iowa, 51503
United States
Heartland Oncology and Hematology LLP
Council Bluffs, Iowa, 51503
United States
Methodist Jennie Edmundson Hospital
Council Bluffs, Iowa, 51503
United States
Iowa Methodist Medical Center
Des Moines, Iowa, 50309
United States
Mission Cancer and Blood - Des Moines
Des Moines, Iowa, 50309
United States
McFarland Clinic - Trinity Cancer Center
Fort Dodge, Iowa, 50501
United States
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa, 52242
United States
McFarland Clinic - Jefferson
Jefferson, Iowa, 50129
United States
McFarland Clinic - Marshalltown
Marshalltown, Iowa, 50158
United States
Siouxland Regional Cancer Center
Sioux City, Iowa, 51101
United States
Central Care Cancer Center - Garden City
Garden City, Kansas, 67846
United States
Central Care Cancer Center - Great Bend
Great Bend, Kansas, 67530
United States
HaysMed
Hays, Kansas, 67601
United States
Lawrence Memorial Hospital
Lawrence, Kansas, 66044
United States
Olathe Health Cancer Center
Olathe, Kansas, 66061
United States
Freeman Physician Group of Pittsburg
Pittsburg, Kansas, 66762
United States
Salina Regional Health Center
Salina, Kansas, 67401
United States
University of Kansas Health System Saint Francis Campus
Topeka, Kansas, 66606
United States
Flaget Memorial Hospital
Bardstown, Kentucky, 40004
United States
Commonwealth Cancer Center-Corbin
Corbin, Kentucky, 40701
United States
Saint Joseph Hospital
Lexington, Kentucky, 40504
United States
Saint Joseph Radiation Oncology Resource Center
Lexington, Kentucky, 40504
United States
Saint Joseph Hospital East
Lexington, Kentucky, 40509
United States
University of Kentucky/Markey Cancer Center
Lexington, Kentucky, 40536
United States
Saint Joseph London
London, Kentucky, 40741
United States
Saint Joseph Mount Sterling
Mount Sterling, Kentucky, 40353
United States
Mercy Health - Paducah Cancer Center
Paducah, Kentucky, 42003
United States
Christiana Care - Union Hospital
Elkton, Maryland, 21921
United States
Boston Medical Center
Boston, Massachusetts, 02118
United States
Dana-Farber Cancer Institute
Boston, Massachusetts, 02215
United States
Steward Saint Elizabeth's Medical Center
Brighton, Massachusetts, 02135
United States
Dana-Farber Cancer Institute at Foxborough
Foxboro, Massachusetts, 02035
United States
Dana Farber-Merrimack Valley
Methuen, Massachusetts, 01844
United States
Dana-Farber/Brigham and Women's Cancer Center at Milford Regional
Milford, Massachusetts, 01757
United States
Dana-Farber/Brigham and Women's Cancer Center at South Shore
South Weymouth, Massachusetts, 02190
United States
Hickman Cancer Center
Adrian, Michigan, 49221
United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan, 48106
United States
McLaren Cancer Institute-Bay City
Bay City, Michigan, 48706
United States
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, Michigan, 48114
United States
Trinity Health Medical Center - Brighton
Brighton, Michigan, 48114
United States
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton, Michigan, 48188
United States
Trinity Health Medical Center - Canton
Canton, Michigan, 48188
United States
Caro Cancer Center
Caro, Michigan, 48723
United States
Chelsea Hospital
Chelsea, Michigan, 48118
United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, Michigan, 48118
United States
Hematology Oncology Consultants-Clarkston
Clarkston, Michigan, 48346
United States
McLaren Cancer Institute-Clarkston
Clarkston, Michigan, 48346
United States
Newland Medical Associates-Clarkston
Clarkston, Michigan, 48346
United States
Corewell Health Dearborn Hospital
Dearborn, Michigan, 48124
United States
Wayne State University/Karmanos Cancer Institute
Detroit, Michigan, 48201
United States
Henry Ford Health Saint John Hospital
Detroit, Michigan, 48236
United States
Great Lakes Cancer Management Specialists-Doctors Park
East China Township, Michigan, 48054
United States
OSF Saint Francis Hospital and Medical Group
Escanaba, Michigan, 49829
United States
Weisberg Cancer Treatment Center
Farmington Hills, Michigan, 48334
United States
Corewell Health Farmington Hills Hospital
Farmington Hills, Michigan, 48336
United States
Genesee Cancer and Blood Disease Treatment Center
Flint, Michigan, 48503
United States
Genesee Hematology Oncology PC
Flint, Michigan, 48503
United States
Genesys Hurley Cancer Institute
Flint, Michigan, 48503
United States
Hurley Medical Center
Flint, Michigan, 48503
United States
McLaren Cancer Institute-Flint
Flint, Michigan, 48532
United States
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Grosse Pointe Woods, Michigan, 48236
United States
Henry Ford Saint John Hospital - Academic
Grosse Pointe Woods, Michigan, 48236
United States
Henry Ford Saint John Hospital - Breast
Grosse Pointe Woods, Michigan, 48236
United States
Karmanos Cancer Institute at McLaren Greater Lansing
Lansing, Michigan, 48910
United States
University of Michigan Health - Sparrow Lansing
Lansing, Michigan, 48912
United States
McLaren Cancer Institute-Lapeer Region
Lapeer, Michigan, 48446
United States
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan, 48154
United States
Great Lakes Cancer Management Specialists-Macomb Medical Campus
Macomb, Michigan, 48044
United States
Henry Ford Warren Hospital - Breast Macomb
Macomb, Michigan, 48044
United States
Saint Mary's Oncology/Hematology Associates of Marlette
Marlette, Michigan, 48453
United States
Toledo Clinic Cancer Centers-Monroe
Monroe, Michigan, 48162
United States
McLaren Cancer Institute-Macomb
Mount Clemens, Michigan, 48043
United States
McLaren Cancer Institute-Northern Michigan
Petoskey, Michigan, 49770
United States
Hope Cancer Center
Pontiac, Michigan, 48341
United States
Michigan Healthcare Professionals Pontiac
Pontiac, Michigan, 48341
United States
Newland Medical Associates-Pontiac
Pontiac, Michigan, 48341
United States
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, Michigan, 48341
United States
McLaren-Port Huron
Port Huron, Michigan, 48060
United States
Oakland Colon Rectal Associates
Royal Oak, Michigan, 48067
United States
Cancer Care Associates PC
Royal Oak, Michigan, 48073
United States
Comprehensive Medical Center PLLC
Royal Oak, Michigan, 48073
United States
Corewell Health William Beaumont University Hospital
Royal Oak, Michigan, 48073
United States
Hematology Oncology Consultants PC
Royal Oak, Michigan, 48073
United States
Oakland Medical Group
Royal Oak, Michigan, 48073
United States
MyMichigan Medical Center Saginaw
Saginaw, Michigan, 48601
United States
Oncology Hematology Associates of Saginaw Valley PC
Saginaw, Michigan, 48604
United States
Bhadresh Nayak MD PC-Sterling Heights
Sterling Heights, Michigan, 48312
United States
Premier Hematology Oncology Care
Sterling Heights, Michigan, 48312
United States
MyMichigan Medical Center Tawas
Tawas City, Michigan, 48764
United States
Michigan Institute of Urology-Town Center
Troy, Michigan, 48084
United States
Corewell Health Beaumont Troy Hospital
Troy, Michigan, 48085
United States
Hematology Oncology Consultants PC-Troy
Troy, Michigan, 48098
United States
Advanced Breast Care Center PLLC
Warren, Michigan, 48088
United States
Great Lakes Cancer Management Specialists-Macomb Professional Building
Warren, Michigan, 48093
United States
Henry Ford Madison Heights Hospital - Breast
Warren, Michigan, 48093
United States
Macomb Hematology Oncology PC
Warren, Michigan, 48093
United States
Saint John Macomb-Oakland Hospital
Warren, Michigan, 48093
United States
Saint Mary's Oncology/Hematology Associates of West Branch
West Branch, Michigan, 48661
United States
Huron Gastroenterology PC
Ypsilanti, Michigan, 48106
United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan, 48197
United States
Riverwood Healthcare Center
Aitkin, Minnesota, 56431
United States
Essentia Health - Baxter Clinic
Baxter, Minnesota, 56425
United States
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota, 56601
United States
Essentia Health Saint Joseph's Medical Center
Brainerd, Minnesota, 56401
United States
Fairview Ridges Hospital
Burnsville, Minnesota, 55337
United States
Minnesota Oncology - Burnsville
Burnsville, Minnesota, 55337
United States
Cambridge Medical Center
Cambridge, Minnesota, 55008
United States
Mercy Hospital
Coon Rapids, Minnesota, 55433
United States
Essentia Health - Deer River Clinic
Deer River, Minnesota, 56636
United States
Essentia Health Saint Mary's - Detroit Lakes Clinic
Detroit Lakes, Minnesota, 56501
United States
Essentia Health Cancer Center
Duluth, Minnesota, 55805
United States
Essentia Health Saint Mary's Medical Center
Duluth, Minnesota, 55805
United States
Miller-Dwan Hospital
Duluth, Minnesota, 55805
United States
Fairview Southdale Hospital
Edina, Minnesota, 55435
United States
Essentia Health - Ely Clinic
Ely, Minnesota, 55731
United States
Essentia Health - Fosston
Fosston, Minnesota, 56542
United States
Unity Hospital
Fridley, Minnesota, 55432
United States
Essentia Health Hibbing Clinic
Hibbing, Minnesota, 55746
United States
Essentia Health - International Falls Clinic
International Falls, Minnesota, 56649
United States
Fairview Clinics and Surgery Center Maple Grove
Maple Grove, Minnesota, 55369
United States
Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota, 55109
United States
Saint John's Hospital - Healtheast
Maplewood, Minnesota, 55109
United States
Abbott-Northwestern Hospital
Minneapolis, Minnesota, 55407
United States
Hennepin County Medical Center
Minneapolis, Minnesota, 55415
United States
Health Partners Inc
Minneapolis, Minnesota, 55454
United States
Monticello Cancer Center
Monticello, Minnesota, 55362
United States
Essentia Health - Moose Lake Clinic
Moose Lake, Minnesota, 55767
United States
New Ulm Medical Center
New Ulm, Minnesota, 56073
United States
Essentia Health - Park Rapids
Park Rapids, Minnesota, 56470
United States
Fairview Northland Medical Center
Princeton, Minnesota, 55371
United States
North Memorial Medical Health Center
Robbinsdale, Minnesota, 55422
United States
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, Minnesota, 56303
United States
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota, 55416
United States
Regions Hospital
Saint Paul, Minnesota, 55101
United States
United Hospital
Saint Paul, Minnesota, 55102
United States
Essentia Health Sandstone
Sandstone, Minnesota, 55072
United States
Saint Francis Regional Medical Center
Shakopee, Minnesota, 55379
United States
Lakeview Hospital
Stillwater, Minnesota, 55082
United States
Sanford Thief River Falls Medical Center
Thief River Falls, Minnesota, 56701
United States
Essentia Health Virginia Clinic
Virginia, Minnesota, 55792
United States
Ridgeview Medical Center
Waconia, Minnesota, 55387
United States
Rice Memorial Hospital
Willmar, Minnesota, 56201
United States
Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota, 55125
United States
Sanford Cancer Center Worthington
Worthington, Minnesota, 56187
United States
Fairview Lakes Medical Center
Wyoming, Minnesota, 55092
United States
Saint Louis Cancer and Breast Institute-Ballwin
Ballwin, Missouri, 63011
United States
Central Care Cancer Center - Bolivar
Bolivar, Missouri, 65613
United States
Cox Cancer Center Branson
Branson, Missouri, 65616
United States
Saint Francis Medical Center
Cape Girardeau, Missouri, 63703
United States
Southeast Cancer Center
Cape Girardeau, Missouri, 63703
United States
Parkland Health Center - Farmington
Farmington, Missouri, 63640
United States
MU Health Care Goldschmidt Cancer Center
Jefferson City, Missouri, 65109
United States
Freeman Health System
Joplin, Missouri, 64804
United States
Mercy Hospital Joplin
Joplin, Missouri, 64804
United States
University Health Truman Medical Center
Kansas City, Missouri, 64108
United States
Lake Regional Hospital
Osage Beach, Missouri, 65065
United States
Delbert Day Cancer Institute at PCRMC
Rolla, Missouri, 65401
United States
Mercy Clinic-Rolla-Cancer and Hematology
Rolla, Missouri, 65401
United States
Heartland Regional Medical Center
Saint Joseph, Missouri, 64506
United States
Saint Louis Cancer and Breast Institute-South City
Saint Louis, Missouri, 63109
United States
Mercy Hospital South
Saint Louis, Missouri, 63128
United States
Missouri Baptist Medical Center
Saint Louis, Missouri, 63131
United States
Mercy Hospital Saint Louis
Saint Louis, Missouri, 63141
United States
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri, 63670
United States
Mercy Hospital Springfield
Springfield, Missouri, 65804
United States
CoxHealth South Hospital
Springfield, Missouri, 65807
United States
Missouri Baptist Sullivan Hospital
Sullivan, Missouri, 63080
United States
BJC Outpatient Center at Sunset Hills
Sunset Hills, Missouri, 63127
United States
Mercy Hospital Washington
Washington, Missouri, 63090
United States
Community Hospital of Anaconda
Anaconda, Montana, 59711
United States
Billings Clinic Cancer Center
Billings, Montana, 59101
United States
Saint Vincent Frontier Cancer Center
Billings, Montana, 59102
United States
Bozeman Health Deaconess Hospital
Bozeman, Montana, 59715
United States
Saint James Community Hospital and Cancer Treatment Center
Butte, Montana, 59701
United States
Benefis Sletten Cancer Institute
Great Falls, Montana, 59405
United States
Great Falls Clinic
Great Falls, Montana, 59405
United States
Kalispell Regional Medical Center
Kalispell, Montana, 59901
United States
Saint Patrick Hospital - Community Hospital
Missoula, Montana, 59802
United States
Community Medical Center
Missoula, Montana, 59804
United States
Nebraska Medicine-Bellevue
Bellevue, Nebraska, 68123
United States
CHI Health Good Samaritan
Kearney, Nebraska, 68847
United States
Saint Elizabeth Regional Medical Center
Lincoln, Nebraska, 68510
United States
Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
Omaha, Nebraska, 68114
United States
Nebraska Methodist Hospital
Omaha, Nebraska, 68114
United States
Oncology Associates PC
Omaha, Nebraska, 68114
United States
Nebraska Medicine-Village Pointe
Omaha, Nebraska, 68118
United States
Alegent Health Immanuel Medical Center
Omaha, Nebraska, 68122
United States
Alegent Health Bergan Mercy Medical Center
Omaha, Nebraska, 68124
United States
Alegent Health Lakeside Hospital
Omaha, Nebraska, 68130
United States
Creighton University Medical Center
Omaha, Nebraska, 68131
United States
University of Nebraska Medical Center
Omaha, Nebraska, 68198
United States
Midlands Community Hospital
Papillion, Nebraska, 68046
United States
Carson Tahoe Regional Medical Center
Carson City, Nevada, 89703
United States
Cancer and Blood Specialists-Henderson
Henderson, Nevada, 89052
United States
Comprehensive Cancer Centers of Nevada - Henderson
Henderson, Nevada, 89052
United States
Comprehensive Cancer Centers of Nevada-Horizon Ridge
Henderson, Nevada, 89052
United States
Las Vegas Cancer Center-Henderson
Henderson, Nevada, 89052
United States
OptumCare Cancer Care at Seven Hills
Henderson, Nevada, 89052
United States
Comprehensive Cancer Centers of Nevada-Southeast Henderson
Henderson, Nevada, 89074
United States
GenesisCare USA - Henderson
Henderson, Nevada, 89074
United States
Las Vegas Urology - Green Valley
Henderson, Nevada, 89074
United States
Las Vegas Urology - Pebble
Henderson, Nevada, 89074
United States
Urology Specialists of Nevada - Green Valley
Henderson, Nevada, 89074
United States
Las Vegas Urology - Pecos
Las Vegas, Nevada, 89074
United States
OptumCare Cancer Care at Charleston
Las Vegas, Nevada, 89102
United States
University Medical Center of Southern Nevada
Las Vegas, Nevada, 89102
United States
Hope Cancer Care of Nevada
Las Vegas, Nevada, 89103
United States
Radiation Oncology Centers of Nevada Central
Las Vegas, Nevada, 89106
United States
Urology Specialists of Nevada - Central
Las Vegas, Nevada, 89106
United States
GenesisCare USA - Las Vegas
Las Vegas, Nevada, 89109
United States
Sunrise Hospital and Medical Center
Las Vegas, Nevada, 89109
United States
Las Vegas Prostate Cancer Center
Las Vegas, Nevada, 89113
United States
Las Vegas Urology - Sunset
Las Vegas, Nevada, 89113
United States
Urology Specialists of Nevada - Southwest
Las Vegas, Nevada, 89113
United States
Radiation Oncology Centers of Nevada Southeast
Las Vegas, Nevada, 89119
United States
Ann M Wierman MD LTD
Las Vegas, Nevada, 89128
United States
Comprehensive Cancer Centers of Nevada - Northwest
Las Vegas, Nevada, 89128
United States
GenesisCare USA - Vegas Tenaya
Las Vegas, Nevada, 89128
United States
Las Vegas Urology - Cathedral Rock
Las Vegas, Nevada, 89128
United States
Las Vegas Urology - Smoke Ranch
Las Vegas, Nevada, 89128
United States
OptumCare Cancer Care at MountainView
Las Vegas, Nevada, 89128
United States
Urology Specialists of Nevada - Northwest
Las Vegas, Nevada, 89128
United States
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas, Nevada, 89135
United States
Comprehensive Cancer Centers of Nevada - Town Center
Las Vegas, Nevada, 89144
United States
Comprehensive Cancer Centers of Nevada-Summerlin
Las Vegas, Nevada, 89144
United States
Summerlin Hospital Medical Center
Las Vegas, Nevada, 89144
United States
Las Vegas Cancer Center-Medical Center
Las Vegas, Nevada, 89148-2405
United States
Comprehensive Cancer Centers of Nevada
Las Vegas, Nevada, 89148
United States
GenesisCare USA - Fort Apache
Las Vegas, Nevada, 89148
United States
OptumCare Cancer Care at Fort Apache
Las Vegas, Nevada, 89148
United States
Comprehensive Cancer Centers of Nevada - Central Valley
Las Vegas, Nevada, 89169
United States
University Cancer Center
Las Vegas, Nevada, 89169
United States
Hope Cancer Care of Nevada-Pahrump
Pahrump, Nevada, 89048
United States
Renown Regional Medical Center
Reno, Nevada, 89502
United States
Saint Mary's Regional Medical Center
Reno, Nevada, 89503
United States
Radiation Oncology Associates
Reno, Nevada, 89509
United States
The Dana-Farber Cancer Institute at Londonderry
Londonderry, New Hampshire, 03053
United States
Sidney Kimmel Cancer Center Washington Township
Sewell, New Jersey, 08080
United States
University of New Mexico Cancer Center
Albuquerque, New Mexico, 87106
United States
New York-Presbyterian/Brooklyn Methodist Hospital
Brooklyn, New York, 11215
United States
The New York Hospital Medical Center of Queens
Flushing, New York, 11355
United States
Glens Falls Hospital
Glens Falls, New York, 12801
United States
Northwell Health Cancer Institute at Huntington
Greenlawn, New York, 11740
United States
Northwell Health/Center for Advanced Medicine
Lake Success, New York, 11042
United States
Northern Westchester Hospital
Mount Kisco, New York, 10549
United States
Lenox Hill Hospital
New York, New York, 10021
United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York, 10032
United States
Manhattan Eye Ear and Throat Hospital
New York, New York, 10065
United States
NYP/Weill Cornell Medical Center
New York, New York, 10065
United States
Queens Cancer Center
Rego Park, New York, 11374
United States
University of Rochester
Rochester, New York, 14642
United States
Phelps Memorial Hospital Center
Sleepy Hollow, New York, 10591
United States
Wilmot Cancer Institute at Webster
Webster, New York, 14580
United States
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, 27599
United States
Wake Forest University at Clemmons
Clemmons, North Carolina, 27012
United States
Southeastern Medical Oncology Center-Clinton
Clinton, North Carolina, 28328
United States
Southeastern Medical Oncology Center-Goldsboro
Goldsboro, North Carolina, 27534
United States
East Carolina University
Greenville, North Carolina, 27834
United States
Southeastern Medical Oncology Center-Jacksonville
Jacksonville, North Carolina, 28546
United States
FirstHealth of the Carolinas-Moore Regional Hospital
Pinehurst, North Carolina, 28374
United States
Wake Forest Baptist Health - Wilkes Medical Center
Wilkesboro, North Carolina, 28659
United States
Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157
United States
Sanford Bismarck Medical Center
Bismarck, North Dakota, 58501
United States
Essentia Health Cancer Center-South University Clinic
Fargo, North Dakota, 58103
United States
Sanford South University Medical Center
Fargo, North Dakota, 58103
United States
Southpointe-Sanford Medical Center Fargo
Fargo, North Dakota, 58103
United States
Sanford Medical Center Fargo
Fargo, North Dakota, 58104
United States
Sanford Broadway Medical Center
Fargo, North Dakota, 58122
United States
Sanford Roger Maris Cancer Center
Fargo, North Dakota, 58122
United States
Essentia Health - Jamestown Clinic
Jamestown, North Dakota, 58401
United States
Indu and Raj Soin Medical Center
Beavercreek, Ohio, 45431
United States
Strecker Cancer Center-Belpre
Belpre, Ohio, 45714
United States
Saint Elizabeth Boardman Hospital
Boardman, Ohio, 44512
United States
Cleveland Clinic Mercy Hospital
Canton, Ohio, 44708
United States
Dayton Physicians LLC-Miami Valley South
Centerville, Ohio, 45459
United States
Miami Valley Hospital South
Centerville, Ohio, 45459
United States
Adena Regional Medical Center
Chillicothe, Ohio, 45601
United States
Good Samaritan Hospital - Cincinnati
Cincinnati, Ohio, 45220
United States
Oncology Hematology Care Inc-Kenwood
Cincinnati, Ohio, 45236
United States
Bethesda North Hospital
Cincinnati, Ohio, 45242
United States
TriHealth Cancer Institute-Westside
Cincinnati, Ohio, 45247
United States
TriHealth Cancer Institute-Anderson
Cincinnati, Ohio, 45255
United States
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210
United States
Mount Carmel East Hospital
Columbus, Ohio, 43213
United States
Columbus Oncology and Hematology Associates Inc
Columbus, Ohio, 43214
United States
Riverside Methodist Hospital
Columbus, Ohio, 43214
United States
Grant Medical Center
Columbus, Ohio, 43215
United States
The Mark H Zangmeister Center
Columbus, Ohio, 43219
United States
Mount Carmel Health Center West
Columbus, Ohio, 43222
United States
Doctors Hospital
Columbus, Ohio, 43228
United States
Miami Valley Hospital
Dayton, Ohio, 45409
United States
Premier Blood and Cancer Center
Dayton, Ohio, 45409
United States
Dayton Physician LLC - Englewood
Dayton, Ohio, 45415
United States
Miami Valley Hospital North
Dayton, Ohio, 45415
United States
Delaware Health Center-Grady Cancer Center
Delaware, Ohio, 43015
United States
Grady Memorial Hospital
Delaware, Ohio, 43015
United States
Columbus Oncology and Hematology Associates
Dublin, Ohio, 43016
United States
Dublin Methodist Hospital
Dublin, Ohio, 43016
United States
Armes Family Cancer Center
Findlay, Ohio, 45840
United States
Blanchard Valley Hospital
Findlay, Ohio, 45840
United States
Orion Cancer Care
Findlay, Ohio, 45840
United States
Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio, 45005-1066
United States
Dayton Physicians LLC-Atrium
Franklin, Ohio, 45005
United States
Central Ohio Breast and Endocrine Surgery
Gahanna, Ohio, 43230
United States
Dayton Physicians LLC-Wayne
Greenville, Ohio, 45331
United States
Miami Valley Cancer Care and Infusion
Greenville, Ohio, 45331
United States
Wayne Hospital
Greenville, Ohio, 45331
United States
Mount Carmel Grove City Hospital
Grove City, Ohio, 43123
United States
Zangmeister Center Grove City
Grove City, Ohio, 43123
United States
Greater Dayton Cancer Center
Kettering, Ohio, 45409
United States
Kettering Medical Center
Kettering, Ohio, 45429
United States
Fairfield Medical Center
Lancaster, Ohio, 43130
United States
Saint Rita's Medical Center
Lima, Ohio, 45801
United States
OhioHealth Mansfield Hospital
Mansfield, Ohio, 44903
United States
Marietta Memorial Hospital
Marietta, Ohio, 45750
United States
OhioHealth Marion General Hospital
Marion, Ohio, 43302
United States
Memorial Hospital
Marysville, Ohio, 43040
United States
Toledo Clinic Cancer Centers-Maumee
Maumee, Ohio, 43537
United States
Knox Community Hospital
Mount Vernon, Ohio, 43050
United States
Mount Carmel New Albany Surgical Hospital
New Albany, Ohio, 43054
United States
Licking Memorial Hospital
Newark, Ohio, 43055
United States
Newark Radiation Oncology
Newark, Ohio, 43055
United States
Mercy Health Perrysburg Cancer Center
Perrysburg, Ohio, 43551
United States
Southern Ohio Medical Center
Portsmouth, Ohio, 45662
United States
Springfield Regional Cancer Center
Springfield, Ohio, 45504
United States
Springfield Regional Medical Center
Springfield, Ohio, 45504
United States
Mercy Health - Saint Vincent Hospital
Toledo, Ohio, 43608
United States
Mercy Health - Saint Anne Hospital
Toledo, Ohio, 43623
United States
Mercy Health Sylvania Radiation Oncology Center
Toledo, Ohio, 43623
United States
Toledo Clinic Cancer Centers-Toledo
Toledo, Ohio, 43623
United States
Dayton Physicians LLC - Troy
Troy, Ohio, 45373
United States
Upper Valley Medical Center
Troy, Ohio, 45373
United States
Saint Joseph Warren Hospital
Warren, Ohio, 44484
United States
Saint Ann's Hospital
Westerville, Ohio, 43081
United States
Clinton Memorial Hospital/Foster J Boyd Regional Cancer Center
Wilmington, Ohio, 45177
United States
Saint Elizabeth Youngstown Hospital
Youngstown, Ohio, 44501
United States
Genesis Healthcare System Cancer Care Center
Zanesville, Ohio, 43701
United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104
United States
Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma, 73120
United States
Saint Alphonsus Cancer Care Center-Baker City
Baker City, Oregon, 97814
United States
Saint Charles Health System
Bend, Oregon, 97701
United States
Clackamas Radiation Oncology Center
Clackamas, Oregon, 97015
United States
Providence Cancer Institute Clackamas Clinic
Clackamas, Oregon, 97015
United States
Bay Area Hospital
Coos Bay, Oregon, 97420
United States
Providence Newberg Medical Center
Newberg, Oregon, 97132
United States
Saint Alphonsus Cancer Care Center-Ontario
Ontario, Oregon, 97914
United States
Providence Willamette Falls Medical Center
Oregon City, Oregon, 97045
United States
Providence Portland Medical Center
Portland, Oregon, 97213
United States
Providence Saint Vincent Medical Center
Portland, Oregon, 97225
United States
Saint Charles Health System-Redmond
Redmond, Oregon, 97756
United States
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania, 18103
United States
Lehigh Valley Hospital - Muhlenberg
Bethlehem, Pennsylvania, 18017
United States
Christiana Care Health System-Concord Health Center
Chadds Ford, Pennsylvania, 19317
United States
Geisinger Medical Center
Danville, Pennsylvania, 17822
United States
Pocono Medical Center
East Stroudsburg, Pennsylvania, 18301
United States
Geisinger Medical Center-Cancer Center Hazleton
Hazleton, Pennsylvania, 18201
United States
Lehigh Valley Hospital-Hazleton
Hazleton, Pennsylvania, 18201
United States
Geisinger Medical Oncology-Lewisburg
Lewisburg, Pennsylvania, 17837
United States
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107
United States
Geisinger Cancer Services-Pottsville
Pottsville, Pennsylvania, 17901
United States
Community Medical Center
Scranton, Pennsylvania, 18510
United States
Reading Hospital
West Reading, Pennsylvania, 19611
United States
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania, 18711
United States
Asplundh Cancer Pavilion
Willow Grove, Pennsylvania, 19090
United States
Medical University of South Carolina
Charleston, South Carolina, 29425
United States
Avera Cancer Institute-Aberdeen
Aberdeen, South Dakota, 57401
United States
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota, 57104
United States
Avera Cancer Institute
Sioux Falls, South Dakota, 57105
United States
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, 57117-5134
United States
Avera Cancer Institute at Yankton
Yankton, South Dakota, 57078
United States
Parkland Memorial Hospital
Dallas, Texas, 75235
United States
UT Southwestern Simmons Cancer Center - RedBird
Dallas, Texas, 75237
United States
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, 75390
United States
Tarrant County Hospital District/JPS Health Network
Fort Worth, Texas, 76104
United States
UT Southwestern/Simmons Cancer Center-Fort Worth
Fort Worth, Texas, 76104
United States
UT Southwestern Clinical Center at Richardson/Plano
Richardson, Texas, 75080
United States
Farmington Health Center
Farmington, Utah, 84025
United States
University of Utah Sugarhouse Health Center
Salt Lake City, Utah, 84106
United States
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah, 84112
United States
Central Vermont Medical Center/National Life Cancer Treatment
Berlin, Vermont, 05602
United States
University of Vermont Medical Center
Burlington, Vermont, 05401
United States
University of Vermont and State Agricultural College
Burlington, Vermont, 05405
United States
Inova Schar Cancer Institute
Fairfax, Virginia, 22031
United States
Inova Fairfax Hospital
Falls Church, Virginia, 22042
United States
Centra Alan B Pearson Regional Cancer Center
Lynchburg, Virginia, 24501
United States
Virginia Cancer Institute
Richmond, Virginia, 23229
United States
VCU Massey Cancer Center at Stony Point
Richmond, Virginia, 23235
United States
Virginia Commonwealth University/Massey Cancer Center
Richmond, Virginia, 23298
United States
VCU Community Memorial Health Center
South Hill, Virginia, 23970
United States
Providence Regional Cancer System-Aberdeen
Aberdeen, Washington, 98520
United States
Overlake Medical Center
Bellevue, Washington, 98004
United States
PeaceHealth Saint Joseph Medical Center
Bellingham, Washington, 98225
United States
Providence Regional Cancer System-Centralia
Centralia, Washington, 98531
United States
Swedish Cancer Institute-Edmonds
Edmonds, Washington, 98026
United States
Providence Regional Cancer Partnership
Everett, Washington, 98201
United States
Swedish Cancer Institute-Issaquah
Issaquah, Washington, 98029
United States
Kadlec Clinic Hematology and Oncology
Kennewick, Washington, 99336
United States
Providence Regional Cancer System-Lacey
Lacey, Washington, 98503
United States
PeaceHealth Saint John Medical Center
Longview, Washington, 98632
United States
Skagit Regional Health Cancer Care Center
Mount Vernon, Washington, 98274
United States
Jefferson Healthcare
Port Townsend, Washington, 98368
United States
Valley Medical Center
Renton, Washington, 98055
United States
Swedish Medical Center-Ballard Campus
Seattle, Washington, 98107
United States
Swedish Medical Center-Cherry Hill
Seattle, Washington, 98122-5711
United States
Swedish Medical Center-First Hill
Seattle, Washington, 98122
United States
PeaceHealth United General Medical Center
Sedro-Woolley, Washington, 98284
United States
Providence Regional Cancer System-Shelton
Shelton, Washington, 98584
United States
Saint Michael Cancer Center
Silverdale, Washington, 98383
United States
PeaceHealth Southwest Medical Center
Vancouver, Washington, 98664
United States
Providence Saint Mary Regional Cancer Center
Walla Walla, Washington, 99362
United States
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Yakima, Washington, 98902
United States
Providence Regional Cancer System-Yelm
Yelm, Washington, 98597
United States
West Virginia University Charleston Division
Charleston, West Virginia, 25304
United States
Langlade Hospital and Cancer Center
Antigo, Wisconsin, 54409
United States
Duluth Clinic Ashland
Ashland, Wisconsin, 54806
United States
Northwest Wisconsin Cancer Center
Ashland, Wisconsin, 54806
United States
Aurora Cancer Care-Southern Lakes VLCC
Burlington, Wisconsin, 53105
United States
Marshfield Clinic-Chippewa Center
Chippewa Falls, Wisconsin, 54729
United States
Aurora Saint Luke's South Shore
Cudahy, Wisconsin, 53110
United States
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin, 54701
United States
Aurora Health Care Germantown Health Center
Germantown, Wisconsin, 53022
United States
Aurora Cancer Care-Grafton
Grafton, Wisconsin, 53024
United States
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin, 54301
United States
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, Wisconsin, 54303
United States
Aurora BayCare Medical Center
Green Bay, Wisconsin, 54311
United States
Essentia Health-Hayward Clinic
Hayward, Wisconsin, 54843
United States
Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin, 53142
United States
Gundersen Lutheran Medical Center
La Crosse, Wisconsin, 54601
United States
Marshfield Medical Center - Ladysmith
Ladysmith, Wisconsin, 54848
United States
Aurora Bay Area Medical Group-Marinette
Marinette, Wisconsin, 54143
United States
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin, 54449
United States
Aspirus Medford Hospital
Medford, Wisconsin, 54451
United States
Aurora Cancer Care-Milwaukee
Milwaukee, Wisconsin, 53209
United States
Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin, 53215
United States
Aurora Sinai Medical Center
Milwaukee, Wisconsin, 53233
United States
Marshfield Clinic-Minocqua Center
Minocqua, Wisconsin, 54548
United States
ProHealth D N Greenwald Center
Mukwonago, Wisconsin, 53149
United States
Marshfield Medical Center - Neillsville
Neillsville, Wisconsin, 54456
United States
Cancer Center of Western Wisconsin
New Richmond, Wisconsin, 54017
United States
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin, 53066
United States
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls, Wisconsin, 54154
United States
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh, Wisconsin, 54904
United States
Aurora Cancer Care-Racine
Racine, Wisconsin, 53406
United States
Ascension Saint Mary's Hospital
Rhinelander, Wisconsin, 54501
United States
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin, 54868
United States
Saint Vincent Hospital Cancer Center at Sheboygan
Sheboygan, Wisconsin, 53081
United States
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin, 53081
United States
Essentia Health-Spooner Clinic
Spooner, Wisconsin, 54801
United States
Ascension Saint Michael's Hospital
Stevens Point, Wisconsin, 54481
United States
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin, 54482
United States
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, Wisconsin, 54235-1495
United States
Aurora Medical Center in Summit
Summit, Wisconsin, 53066
United States
Essentia Health Saint Mary's Hospital - Superior
Superior, Wisconsin, 54880
United States
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin, 54241
United States
ProHealth Waukesha Memorial Hospital
Waukesha, Wisconsin, 53188
United States
UW Cancer Center at ProHealth Care
Waukesha, Wisconsin, 53188
United States
Aspirus Regional Cancer Center
Wausau, Wisconsin, 54401
United States
Marshfield Clinic-Wausau Center
Wausau, Wisconsin, 54401
United States
Aurora Cancer Care-Milwaukee West
Wauwatosa, Wisconsin, 53226
United States
Aurora West Allis Medical Center
West Allis, Wisconsin, 53227
United States
Marshfield Medical Center - Weston
Weston, Wisconsin, 54476
United States
Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids, Wisconsin, 54494
United States
Marshfield Clinic - Wisconsin Rapids Center
Wisconsin Rapids, Wisconsin, 54494
United States
Cheyenne Regional Medical Center-West
Cheyenne, Wyoming, 82001
United States
Billings Clinic-Cody
Cody, Wyoming, 82414
United States
Welch Cancer Center
Sheridan, Wyoming, 82801
United States

Collaborators and Investigators

Sponsor: Alliance for Clinical Trials in Oncology

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-01-23
Study Completion Date2028-11-08

Study Record Updates

Study Start Date2023-01-23
Study Completion Date2028-11-08

Terms related to this study

Additional Relevant MeSH Terms

  • Advanced Esophageal Adenocarcinoma
  • Advanced Gastric Adenocarcinoma
  • Advanced Gastroesophageal Junction Adenocarcinoma
  • Clinical Stage III Esophageal Adenocarcinoma AJCC v8
  • Clinical Stage III Gastric Cancer AJCC v8
  • Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Clinical Stage IV Esophageal Adenocarcinoma AJCC v8
  • Clinical Stage IV Gastric Cancer AJCC v8
  • Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8
  • Metastatic Esophageal Adenocarcinoma
  • Metastatic Gastric Adenocarcinoma
  • Metastatic Gastroesophageal Junction Adenocarcinoma
  • Unresectable Esophageal Adenocarcinoma
  • Unresectable Gastric Adenocarcinoma
  • Unresectable Gastroesophageal Junction Adenocarcinoma