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Tissue Destruction and Healing in Celiac Disease

Description

The purpose of this clinical study is to learn more about celiac disease pathogenesis and clinical symptoms. In particular, this study will examine the interactions between biological factors such as, intestinal epithelial cells, microbiota, immune system, genetics, and gluten and their effect on celiac disease clinical symptoms, and severity of tissue destruction and its ability to heal in individuals with celiac disease. Information collected in the study will help researchers to generate better resources to advance celiac disease patient care.

Conditions

Celiac Disease
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Related Conditions:

Celiac Disease

Study Overview

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Study Details

Study overview

The purpose of this clinical study is to learn more about celiac disease pathogenesis and clinical symptoms. In particular, this study will examine the interactions between biological factors such as, intestinal epithelial cells, microbiota, immune system, genetics, and gluten and their effect on celiac disease clinical symptoms, and severity of tissue destruction and its ability to heal in individuals with celiac disease. Information collected in the study will help researchers to generate better resources to advance celiac disease patient care.

Tissue Destruction and Healing in Celiac Disease

Tissue Destruction and Healing in Celiac Disease

Condition
Celiac Disease
Intervention / Treatment

-

Contacts and Locations

Pasadena

California Institute of Technology, Pasadena, California, United States, 91125

Chicago

The University of Chicago, Chicago, Illinois, United States, 60637

Rochester

Mayo Clinic, Rochester, Minnesota, United States, 55902

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Age 18 to 75 years old
  • 2. Diagnosis of Celiac disease for at least 12 months by intestinal biopsy
  • 3. Follow a strict gluten-free diet for at least the 12 consecutive months
  • 1. Age 18 to 75 years old
  • 2. Showing typical celiac disease symptoms
  • 3. Not on a gluten-free diet
  • 1. Age 18 to 75 years old
  • 2. Females who are not pregnant
  • 1. Diagnosis of any severe complication of celiac disease
  • 2. Diagnosis of other chronic, active GI disease
  • 3. Selective IgA deficiency
  • 4. Severe reaction to gluten exposure
  • 5. Any clinically significant diseases
  • 6. History of significant substance or alcohol abuse
  • 7. Pregnant or lactating
  • 8. Diagnosis of blood clotting disorders
  • 1. History of chronic inflammatory gastrointestinal disease
  • 2. Gastrointestinal illness within the 4-week period prior to screening
  • 3. History of lymphoproliferative disease
  • 4. Uncontrolled blood clotting disorders
  • 5. Any clinically significant diseases
  • 6. History of significant substance or alcohol abuse
  • 1. Taking antibiotics, proton pump inhibitors, aspirin, or non-steroidal anti-inflammatory drugs
  • 2. Known intestinal inflammation
  • 3. Prior gastrointestinal surgery
  • 4. Taking of antiplatelet agents or anticoagulants
  • 5. Family history of celiac disease

Ages Eligible for Study

18 Years to 75 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Chicago,

Bana Jabri, MD, PRINCIPAL_INVESTIGATOR, University of Chicago

Study Record Dates

2027-06-30