RECRUITING

AMPLIFY Study: Transcutaneous Spinal Direct Current Stimulation to Enhance Locomotor Rehabilitation After SCI

Description

Locomotor training (LT) facilitates recovery of spinal locomotor networks after incomplete spinal cord injury (ISCI), but walking impairments persist. A limitation of LT is insufficient excitation of spinal locomotor circuits to induce neuroplastic recovery. Transcutaneous spinal direct current stimulation (tsDCS) is a non-invasive approach to increase spinal excitation and modulate spinal reflexes. The study will examine if tsDCS combined with LT enhances locomotor rehabilitation after ISCI.

Conditions

Spinal Cord Injuries
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Related Conditions:

Spinal Cord Injuries

Study Overview

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Study Details

Study overview

Locomotor training (LT) facilitates recovery of spinal locomotor networks after incomplete spinal cord injury (ISCI), but walking impairments persist. A limitation of LT is insufficient excitation of spinal locomotor circuits to induce neuroplastic recovery. Transcutaneous spinal direct current stimulation (tsDCS) is a non-invasive approach to increase spinal excitation and modulate spinal reflexes. The study will examine if tsDCS combined with LT enhances locomotor rehabilitation after ISCI.

Transcutaneous Spinal Direct Current Stimulation to Enhance Locomotor Rehabilitation After Spinal Cord Injury

AMPLIFY Study: Transcutaneous Spinal Direct Current Stimulation to Enhance Locomotor Rehabilitation After SCI

Condition
Spinal Cord Injuries
Intervention / Treatment

-

Contacts and Locations

Jacksonville

Brooks Rehabilitation Hospital, Jacksonville, Florida, United States, 32216

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Adults 18 to 65 years of age
  • * Single chronic SCI for ≥ 1 year classified as neurologic level T12 or above based on the International Standards for the Neurological Classification of SCI67 and classified according to the American Spinal Injury Association Impairment Scale (AIS) as motor incomplete (AIS C or D) at initial screening
  • * Medical stability with clearance from physician
  • * Ability to walk 3 meters with or without devices, braces, or assistance of one person
  • * Ability to provide informed consent.
  • * Current diagnosis of an additional neurologic condition such as multiple sclerosis, Parkinson's disease, stroke, or brain injury
  • * Presence of unstable or uncontrolled medical conditions such as cardiovascular disease, myocardial infarction (\<1 year prior), pulmonary infection or illness, renal disease, autonomic dysreflexia, infections, pain, heterotopic ossification
  • * Cognitive or communication impairments limiting communication with study staff or ability to provide informed consent
  • * Lower extremity joint contractures limiting the ability to stand upright and practice walking
  • * Skin lesions or wounds affecting participation in walking rehabilitation
  • * Acute or unstable fracture, diagnosis of osteoarthritis or bone impairments affecting safe participation in walking rehabilitation
  • * Severe spasticity or uncontrolled movements limiting participation in walking rehabilitation
  • * Body weight or height that is incompatible with safe use of a support harness and body weight support system
  • * Pain that limits walking or participation in walking rehabilitation
  • * Current participation in rehabilitation to address walking function
  • * Botox injections in lower extremity muscles affecting walking function within 4 months of study enrollment
  • * Legal blindness or severe visual impairment
  • * Known pregnancy
  • * Implanted metal hardware of the spine below the 8th thoracic vertebrae or in region of electrode placement
  • * Implanted cardiac pacemaker or baclofen pump

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Florida,

Emily Fox, DPT, PhD, PRINCIPAL_INVESTIGATOR, University of Florida

Study Record Dates

2025-09