RECRUITING

Brain-Training Treatment for Long COVID in Older Adults

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Conditions

Post-Acute COVID-19 SyndromeComputerized Cognitive RemediationOlder Adults

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This research is being done to collect preliminary data on the potential of computerized "brain-training" exercises for treating Long COVID symptoms in older adults. The investigators hypothesize that computerized brain-training will be an acceptable and feasible intervention for treating Long COVID symptoms in older adults. The investigators also expect to provide initial evidence that computerized brain-training has potential for improving thinking, mood, and other aspects of everyday functioning in older adults with Long COVID.

Official Title

Computerized Cognitive Remediation of Long COVID Symptoms in Older Adults

Quick Facts

Study Start:2023-04-07
Study Completion:2024-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05705193

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:60 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * prior history of COVID-19 based on Centers for Disease Control and Prevention (CDC) guidelines including a positive laboratory test (e.g., nucleic acid amplification test) or a positive rapid test
  2. * age ≥ 60 years old
  3. * current self-reported cognitive symptoms persisting after the acute phase of the illness (i.e., \>4 weeks after COVID-19 symptom onset) that cannot be explained by alternative diagnoses
  4. * evidence of subjective cognitive impairment with a Functional Assessment of Cancer Therapy - Cognitive Function (FACT-Cog) Perceived Cognitive Impairment (PCI) Subscale Score of ≤ 40 and/or endorsing any item on the FACT-Cog PCI Subscale as occurring nearly every day or several times a day
  5. * Telephone Interview for Cognitive Status (TICS) ≥ 27
  6. * fluent in English
  7. * off psychiatric medications or on a stable dose for at least 1 month prior to commencing the study with no intention to change dose prior to completion of the study.
  1. * history of neurological disorder or other medical condition with potential to impair cognitive functioning or interfere with study participation (e.g., epilepsy, stroke, dementia, head trauma followed by persistent neurological deficits or known structural brain abnormalities)
  2. * prior diagnosis of Mild Cognitive Impairment (MCI) or Mild Neurocognitive Disorder unrelated to the participant's history of COVID-19
  3. * history of significant psychiatric illness per Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), criteria that may interfere with study participation or confound results (e.g., schizophrenia or other psychotic disorder, bipolar and related disorders, major depressive disorder with psychotic features, personality disorder)
  4. * history of significant neurodevelopmental condition that may interfere with study participation or confound results (e.g., intellectual disability, autism spectrum disorder)
  5. * alcohol or other substance use disorder within the past 2 years
  6. * significant sensory or motor impairments (e.g., blindness) that may interfere with the ability to complete neuropsychological measures or engage in the intervention

Contacts and Locations

Study Contact

Holly Eddy, Ph.D., LMFT-S
CONTACT
860-679-3751
eddy@uchc.edu
Jennifer Brindisi, M.A.
CONTACT
860-679-7581
brindisi@uchc.edu

Principal Investigator

Cutter Lindbergh, Ph.D.
PRINCIPAL_INVESTIGATOR
UConn Health

Study Locations (Sites)

UConn Health
Farmington, Connecticut, 06030
United States

Collaborators and Investigators

Sponsor: UConn Health

  • Cutter Lindbergh, Ph.D., PRINCIPAL_INVESTIGATOR, UConn Health

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-04-07
Study Completion Date2024-12-31

Study Record Updates

Study Start Date2023-04-07
Study Completion Date2024-12-31

Terms related to this study

Keywords Provided by Researchers

  • Post-Acute COVID-19 Syndrome
  • Computerized Cognitive Remediation
  • Older Adults

Additional Relevant MeSH Terms

  • Post-Acute COVID-19 Syndrome