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Complex And Simple Appendicitis: REstrictive or Liberal Post-operative Antibiotic eXposure (CASA RELAX) - Atrium Health

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Conditions

Appendicitis Surgerypost-operative antibioticsacute appendicitiscomplicated appendicitis

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

To demonstrate the safety, efficacy, and feasibility of short-course post-operative antibiotic treatment for simple and complicated appendicitis

Official Title

Complex And Simple Appendicitis: REstrictive or Liberal Post-operative Antibiotic eXposure (CASA RELAX) Using Desirability of Outcome Ranking (DOOR) and Response Adjusted for Duration of Antibiotic Risk (RADAR)

Quick Facts

Study Start:2023-03-02
Study Completion:2025-07-21
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT05746520

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age ≥ 18 years
  2. * Planned appendectomy (laparoscopic or open)
  3. * Willing and able to provide informed consent
  4. * Working telephone number or reliable method to contact patient after hospital discharge
  1. * Unable to consent
  2. * Pregnant Women
  3. * Prisoners
  4. * immunocompromised as determined by clinical team, or patients actively receiving steroids, chemotherapy, or immunosuppressing medications (for example tacrolimus), or patients with active hematologic malignancy affecting the immune system, leukopenia, or end-stage Acquired immunodeficiency syndrome (AIDS)
  5. * Heart Failure
  6. * Allergy to Bupivacaine
  7. * Unlikely to comply with treatment or follow-up
  8. * Inpatient consultation for appendicitis
  9. * Clinically suspected sepsis based on Sepsis-3 definition
  10. * Current use of antibiotics for other indications
  11. * Type 1 Diabetes or uncontrolled hyperglycemia

Contacts and Locations

Principal Investigator

Rafael Torres Fajardo, MD
PRINCIPAL_INVESTIGATOR
Wake Forest University Health Sciences

Study Locations (Sites)

Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157
United States

Collaborators and Investigators

Sponsor: Wake Forest University Health Sciences

  • Rafael Torres Fajardo, MD, PRINCIPAL_INVESTIGATOR, Wake Forest University Health Sciences

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-03-02
Study Completion Date2025-07-21

Study Record Updates

Study Start Date2023-03-02
Study Completion Date2025-07-21

Terms related to this study

Keywords Provided by Researchers

  • post-operative antibiotics
  • acute appendicitis
  • complicated appendicitis

Additional Relevant MeSH Terms

  • Appendicitis Surgery