RECRUITING

Oropharyngeal Candidiasis (OPC) and S-ECC

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The overall objective of this study is to investigate the association of early Candida infection (known as oral thrush or oropharyngeal candidiasis, OPC) in children during the first year of life with the onset and severity of severe early childhood caries (S-ECC).

Official Title

Association Between Early Candida Infection (Oral Thrush) and Severe Early Childhood Caries (S-ECC)

Quick Facts

Study Start:2025-01-01
Study Completion:2028-08-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05761197

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:9 Months to 24 Months
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:CHILD
Inclusion CriteriaExclusion Criteria
  1. * Male or female individuals at the age of 9-24-month-old
  2. * Must have at least one fully erupted tooth at baseline visit
  3. * Parent/guardian willing and able to provide informed consent
  4. * With or without a history of OPC (the study team will enroll 35 participants with and 35 participants without a history of OPC)
  1. * Presence of a systemic medical condition (e.g. Down syndrome etc.)
  2. * Presence of an orofacial deformity
  3. * Presence of dental caries
  4. * Use of systemic antimicrobial therapy within 30 days of the baseline visit
  5. * Presence of any condition which, in the opinion of the investigator, makes participation in the project not in the individual's best interest.

Contacts and Locations

Study Contact

Yuan Liu, DDS, MS, PhD
CONTACT
215-707-8029
yuan.liu0008@temple.edu

Principal Investigator

Yuan Liu, DDS, MS, PhD
PRINCIPAL_INVESTIGATOR
Temple University Kornberg School of Dentistry

Study Locations (Sites)

Temple University
Philadelphia, Pennsylvania, 19140
United States

Collaborators and Investigators

Sponsor: Temple University

  • Yuan Liu, DDS, MS, PhD, PRINCIPAL_INVESTIGATOR, Temple University Kornberg School of Dentistry

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-01-01
Study Completion Date2028-08-31

Study Record Updates

Study Start Date2025-01-01
Study Completion Date2028-08-31

Terms related to this study

Keywords Provided by Researchers

  • Oral candidiasis
  • Candida infection
  • Oral thrush
  • Early childhood caries
  • Oral Health

Additional Relevant MeSH Terms

  • Candida Infection
  • Oral Thrush
  • Early Childhood Caries