RECRUITING

Oropharyngeal Candidiasis (OPC) and S-ECC

Description

The overall objective of this study is to investigate the association of early Candida infection (known as oral thrush or oropharyngeal candidiasis, OPC) in children during the first year of life with the onset and severity of severe early childhood caries (S-ECC).

Conditions

Candida InfectionOral ThrushEarly Childhood Caries
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Related Conditions:

Candida InfectionOral ThrushEarly Childhood Caries

Study Overview

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Study Details

Study overview

The overall objective of this study is to investigate the association of early Candida infection (known as oral thrush or oropharyngeal candidiasis, OPC) in children during the first year of life with the onset and severity of severe early childhood caries (S-ECC).

Association Between Early Candida Infection (Oral Thrush) and Severe Early Childhood Caries (S-ECC)

Oropharyngeal Candidiasis (OPC) and S-ECC

Condition
Candida Infection
Intervention / Treatment

-

Contacts and Locations

Philadelphia

Temple University, Philadelphia, Pennsylvania, United States, 19140

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Male or female individuals at the age of 9-24-month-old
  • * Must have at least one fully erupted tooth at baseline visit
  • * Parent/guardian willing and able to provide informed consent
  • * With or without a history of OPC (the study team will enroll 35 participants with and 35 participants without a history of OPC)
  • * Presence of a systemic medical condition (e.g. Down syndrome etc.)
  • * Presence of an orofacial deformity
  • * Presence of dental caries
  • * Use of systemic antimicrobial therapy within 30 days of the baseline visit
  • * Presence of any condition which, in the opinion of the investigator, makes participation in the project not in the individual's best interest.

Ages Eligible for Study

9 Months to 24 Months

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Temple University,

Yuan Liu, DDS, MS, PhD, PRINCIPAL_INVESTIGATOR, Temple University Kornberg School of Dentistry

Study Record Dates

2028-08-31