ACTIVE_NOT_RECRUITING

Behavioral Treatment and Memantine in Body Focused Repetitive Behaviors

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of the proposed study is to compare the efficacy of behavioral treatment (BT) to memantine, a psychopharmacological agent, for BFRBs. 28 subjects with trichotillomania (TTM) or skin picking disorder (SPD) will receive 8 weeks of memantine treatment, followed by 8 weeks of comprehensive behavioral therapy (ComB) treatment. The hypothesis to be tested is that behavioral therapy will be associated with superior clinical outcomes as compared to memantine. A second hypothesis is that both memantine and behavioral therapy will demonstrate improvement from baseline to the respective posttreatment assessment.

Official Title

Single-Group Crossover Trial Comparing Behavioral Treatment to Memantine in Body Focused Repetitive Behaviors

Quick Facts

Study Start:2023-08-02
Study Completion:2025-12-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:ACTIVE_NOT_RECRUITING

Study ID

NCT05796752

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Men and women ages 18+
  2. * Current DSM-5 diagnosis of trichotillomania (TTM) or skin picking disorder (SPD)
  3. * Ability to understand and sign the consent form
  4. * Stable dose of medications for at least the past 3 months
  1. * Unstable medical illness based on history or clinically significant abnormalities on baseline physical examination
  2. * Current pregnancy or lactation, or inadequate contraception in women of childbearing potential
  3. * Subjects considered an immediate suicide risk based on the Columbia Suicide Severity rating Scale (C-SSRS)
  4. * Past 12-month DSM-5 diagnosis of psychosis, bipolar disorder, mania, or a substance or alcohol use disorder
  5. * Illegal substance use based on urine toxicology screening
  6. * Previous treatment with memantine
  7. * Previous trial of ComB or similar BT protocol (e,g., habit reversal training)
  8. * Cognitive impairment that interferes with the capacity to understand and self-administer medication or provide written informed consent

Contacts and Locations

Principal Investigator

Jon E Grant, MD, JD, MPH
PRINCIPAL_INVESTIGATOR
University of Chicago
Gregory Chasson, PhD
PRINCIPAL_INVESTIGATOR
University of Chicago

Study Locations (Sites)

University of Chicago Medical Center
Chicago, Illinois, 60637
United States

Collaborators and Investigators

Sponsor: University of Chicago

  • Jon E Grant, MD, JD, MPH, PRINCIPAL_INVESTIGATOR, University of Chicago
  • Gregory Chasson, PhD, PRINCIPAL_INVESTIGATOR, University of Chicago

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-08-02
Study Completion Date2025-12-01

Study Record Updates

Study Start Date2023-08-02
Study Completion Date2025-12-01

Terms related to this study

Additional Relevant MeSH Terms

  • Skin-Picking
  • Trichotillomania (Hair-Pulling Disorder)