RECRUITING

Stimulation-Induced Changes in Fronto-Limbic Network

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this research is to better understand how emotion processing unfolds in the brain using stereoelectroencephalography (sEEG) and direct brain stimulation. This study will use standard behavioral emotion processing tasks combined with neural recording and direct brain stimulation to assess different aspects of emotion processing. Stimulation pulses during pre and post-test periods will assess the effects of stimulation before and after conditioning, the results of which will be combined with results from the activity of each electrode during the emotion tasks to inform us of the nature of emotion processing in the brain and allow us to devise brain modulation protocols in the future.

Official Title

Stimulation-Induced Changes in Fronto-Limbic Connectivity Control Regulation of the Emotional Response to Threat

Quick Facts

Study Start:2023-03-01
Study Completion:2025-06-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05854160

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * 1) implantation of sEEG electrodes for SOC epilepsy surgery evaluation
  2. * 2) cognitive ability to perform simple tasks and to understand instructions
  3. * 3) implanted electrodes in the amygdala and medial PFC regions
  4. * 4) competency to understand and sign a written informed consent.
  1. * 1) an inability to complete the task

Contacts and Locations

Study Contact

Rebekah Chatfield, BS
CONTACT
(205) 975-3477
joyb3@uab.edu

Principal Investigator

Adam Goodman, PhD
PRINCIPAL_INVESTIGATOR
University of Alabama at Birmingham

Study Locations (Sites)

Epilepsy Monitoring Unit UAB Hospital
Birmingham, Alabama, 35233
United States

Collaborators and Investigators

Sponsor: University of Alabama at Birmingham

  • Adam Goodman, PhD, PRINCIPAL_INVESTIGATOR, University of Alabama at Birmingham

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-03-01
Study Completion Date2025-06-01

Study Record Updates

Study Start Date2023-03-01
Study Completion Date2025-06-01

Terms related to this study

Keywords Provided by Researchers

  • epilepsy
  • comorbid mental health disorders
  • sEEG
  • Anxiety
  • Fronto-limbic network
  • Pavlovian fear conditioning paradigm

Additional Relevant MeSH Terms

  • Epilepsy
  • Mental Disorders