RECRUITING

Exercise Neuroprotection in Parkinson's Disease

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to explore the relationships of exercise on inflammation in the body of older adults and people with Parkinson's disease (PD). This is important research for older adults but is especially important for people with PD because neuroinflammation is the main pathological mechanism that is responsible for neuron cell death in this neurodegenerative disease. As PD is a progressive disease, halting or slowing the degeneration is an important research target. Halting or slowing the disease progress is known as neuroprotection. Exercise is an attractive therapeutic treatment for people with PD as it has a lot of multi-systemic benefits, but also there is a lot of evidence to suggest that it helps improve symptoms and slow the progression of the disease. Exercise has been theorized to decrease inflammation and, therefore, has a lot of promise as a neuroprotective agent in slowing or halting the degeneration in PD. Unfortunately, there is not a lot of research that has looked into the effect of exercise on the biological processes of inflammation. Thus, the purpose of this study is to investigate the biological evidence that underlies the positive effect of exercise in people with PD.

Official Title

Exploring the Biological Basis for Exercise Neuroprotection in Parkinson's Disease

Quick Facts

Study Start:2024-08-29
Study Completion:2026-12-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05854524

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:30 Years to 85 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Merrill Landers, DPT, PhD
CONTACT
17028951377
merrill.landers@unlv.edu

Principal Investigator

Merrill Landers, DPT, PhD
PRINCIPAL_INVESTIGATOR
University of Nevada, Las Vegas

Study Locations (Sites)

Gait and Balance Laboratory, 217 Bigelow Health Sciences Building, UNLV
Las Vegas, Nevada, 89154
United States

Collaborators and Investigators

Sponsor: University of Nevada, Las Vegas

  • Merrill Landers, DPT, PhD, PRINCIPAL_INVESTIGATOR, University of Nevada, Las Vegas

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-08-29
Study Completion Date2026-12-30

Study Record Updates

Study Start Date2024-08-29
Study Completion Date2026-12-30

Terms related to this study

Keywords Provided by Researchers

  • Exercise
  • Inflammation
  • Physical activity
  • Neuroprotection

Additional Relevant MeSH Terms

  • Parkinson Disease